The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
Quantity and Distribution of Eosinophils in the Gastrointestinal Tract of Children
Abstract
There are a lack of data on the quantity and location of eosinophils in the gastrointestinal tract of healthy individuals. Accordingly, we examined gastrointestinal biopsies obtained during endoscopic evaluation of pediatric patients. Biopsies were previously interpreted as having no diagnostic abnormality. The presence of extracellular eosinophil constituents and the quantity of eosinophils in atopic versus nonatopic individuals was determined. In the esophagus, eosinophils were present in only 2.7% of high-power fields (hpf), with a mean value of 0.03 ± 0.10 eosinophils/hpf (mean ± standard deviation) and a maximum of 1 eosinophil/hpf. Examination of the antrum and fundus revealed similar numbers of eosinophils in the lamina propria (1.9 ± 1.3 and 2.1 ± 2.4 eosinophils/hpf, respectively), with no eosinophils observed in the surface epithelium. In the small intestine, there were 9.6 ± 5.3 (maximum, 26 eosinophils/hpf) and 12.4 ± 5.4 eosinophils/hpf (maximum, 28 eosinophils/hpf) in the intercryptal lamina propria of the duodenum and ileum, respectively. The number of eosinophils in the surface epithelium and crypt epithelium was minimal. In the large intestine, the highest concentration of eosinophils was observed in the cecum (20.3 ±8.2 eosinophils/hpf; maximum, 50 eosinophils/hpf), and there were lower concentrations in the transverse and sigmoid colon (16.3 ± 5.6 and 8.3 ± 5.9 eosinophils/hpf, respectively). The percentage of fields demonstrating extracellular eosinophil granules in all gastrointestinal segments was 70% to 93%, and extracellular granules were most numerous at the edge of the biopsy ( P < 0.05). Atopic and nonatopic patients had comparable numbers of eosinophils. These data establish baseline gastrointestinal eosinophil values in pediatric patients without apparent pathological disease.
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Cites
The Effect of Infections on Susceptibility to Autoimmune and Allergic Diseases
Bach, J.-F. (2002) · New England Journal of Medicine · doi:10.1056/nejmra020100 · Cited by 2,687
Eosinophilic gastrointestinal disorders (EGID)
Rothenberg, M. E. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2003.10.047 · Cited by 923
Self-citationTalley, N. J., Shorter, R. G., Phillips, S. F., & Zinsmeister, A. R. (1990) · Gut · doi:10.1136/gut.31.1.54 · Cited by 864
Noel, R. J., Putnam, P. E., & Rothenberg, M. E. (2004) · New England Journal of Medicine · doi:10.1056/nejm200408263510924 · Cited by 721
Self-citationFundamental signals that regulate eosinophil homing to the gastrointestinal tract
Mishra, A., Hogan, S. P., Lee, J. J., Foster, P. S., & Rothenberg, M. E. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6560 · Cited by 400
Self-citationEosinophilic esophagitis: Escalating epidemiology?
Straumann, A., & Simon, H.-U. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.11.006 · Cited by 393
Zur Kenntnis der allergischen Affektionen des Verdauungskanals vom Standpunkt des Chirurgen aus
Kaijser, R. (1937) · Medical Entomology and Zoology · Cited by 299
Rothenberg, M. E., Mishra, A., Brandt, E. B., & Hogan, S. P. (2001) · Immunological Reviews · doi:10.1034/j.1600-065x.2001.790114.x · Cited by 235
Self-citationEosinophil infiltration and degranulation in normal human tissue
Kato, M., Kephart, G. M., Talley, N. J., Wagner, J. M., Sarr, M. G., Bonno, M., McGovern, T. W., & Gleich, G. J. (1998) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199811)252:3<418::aid-ar10>3.0.co;2-1 · Cited by 208
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Cited by
Furuta, G. T., Liacouras, C. A., Collins, M. H., Gupta, S. K., Justinich, C., Putnam, P. E., Bonis, P., Hassall, E., Straumann, A., & Rothenberg, M. E. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.08.017 · Cited by 1,673
Self-citationPediatric patients with eosinophilic esophagitis: An 8-year follow-up
Assa'ad, A. H., Putnam, P. E., Collins, M. H., Akers, R. M., Jameson, S. C., Kirby, C. L., Buckmeier, B. K., Bullock, J. Z., Collier, A. R., Konikoff, M. R., et al. (2007) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.10.044 · Cited by 331
Self-citationHigh prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders
Abonia, J. P., Wen, T., Stucke, E. M., Grotjan, T., Griffith, M. S., Kemme, K. A., Collins, M. H., Putnam, P. E., Franciosi, J. P., von Tiehl, K. F., et al. (2013) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2013.02.030 · Cited by 195
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Metadata
- Authors
- DeBrosse, C. W., Case, J. W., Putnam, P. E., Collins, M. H., & Rothenberg, M. E.
- Venue
- Pediatric and Developmental Pathology
- Publisher
- SAGE Publications
- Published
- 2006-05
- Volume
- 9
- Issue
- 3
- Pages
- 210-218
- ISSN
- 1093-5266 (ISSN-L)
- 1615-5742
- OpenAlex
- W1993671000
- Cited by
- 278
- References
- 20
- FWCI
- 11.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- DeBrosse, C. W., Case, J. W., Putnam, P. E., Collins, M. H., & Rothenberg, M. E. (2006). Quantity and Distribution of Eosinophils in the Gastrointestinal Tract of Children. Pediatric and Developmental Pathology. https://doi.org/10.2350/11-05-0130.1
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