A high omega-3 fatty acid diet reduces retinal lesions in a murine model of macular degeneration
Open accessAbstract
Age-related macular degeneration (AMD) is one of the leading cause of blindness among the elderly; however, current therapy options are limited. Epidemiological studies have shown that a diet that is high in omega-3 polyunsaturated (n-3) fatty acids can slow disease progression in patients with advanced AMD. In this study, we evaluated the effect of such a diet on the retinas of Ccl2(-/-)/Cx3cr1(-/-) mice, a model that develops AMD-like retinal lesions that include focal deep retinal lesions, abnormal retinal pigment epithelium, photoreceptor degeneration, and A2E accumulation. Ccl2(-/-)/Cx3cr1(-/-) mice that ingested a high n-3 fatty acid diet showed a slower progression of retinal lesions compared with the low n-3 fatty acids group. Some mice that were given high levels of n-3 fatty acids had lesion reversion. We found a shunted arachidonic acid metabolism that resulted in decreased pro-inflammatory derivatives (prostaglandin E(2) and leukotriene B(4)) and an increased anti-inflammatory derivative (prostaglandin D(2)). We also measured lower ocular TNF-alpha and IL-6 transcript levels in the mice fed a diet of high n-3 fatty acids. Our findings in these mice are in line with human studies of AMD risk reduction by long-chain n-3 fatty acids. This murine model provides a useful tool to evaluate therapies that might delay the development of AMD.
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High omega-3 diet ameliorates retinal AMD-like lesions in Ccl2−/−/Cx3cr1−/− mice.
“high omega-3 diet ameliorates retinal AMD-like lesions in Ccl2−/−/Cx3cr1−/− mice”
From Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD) (2010) · cites this paper as Tuo et al., 2009
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References 45 · Cited by 80
- Authors
- Tuo, J., Ross, R. J., Herzlich, A. A., Shen, D., Ding, X., Zhou, M., Coon, S. L., Hussein, N., Salem, N., & Chan, C.-C.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Chan, Chi-Chao
- Venue
- The American Journal of Pathology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 175
- Issue
- 2
- Pages
- 799-807
- ISSN
- 0002-9440 (ISSN-L)
- PMC
- PMC2716974
- OpenAlex
- W2015057944
- Cited by
- 80
- References
- 45
- Citations by year
- 2025: 1 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 2 · 2020: 6 · 2019: 2 · 2018: 3 · 2017: 9 · 2016: 1 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 8
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- American Journal Of Pathology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Health Assistance Foundation
- National Institutes of Health
- National Eye Institute
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- age-related macular degeneration, omega-3 fatty acids, diet, retinal lesions, arachidonic acid metabolism, prostaglandin E2, leukotriene B4, prostaglandin D2, TNF-α, interleukin-6, retinal pigment epithelium, photoreceptor degeneration, inflammation
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Diet, Disease Models, Animal, Macular Degeneration, Mice, Mutant Strains, Pyridinium Compounds, Retinoids, Transcription, Genetic, Tumor Necrosis Factor-alpha, Fatty Acids, Omega-3, Interleukin-6, Arachidonic Acid, Chemokine CCL2, Receptors, Chemokine, Mice, Retinal Pigment Epithelium
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