PTEN, PIK3CA, p-AKT, and p-p70S6K Status

Esteva, Francisco J., Guo, Hua, Zhang, Siyuan, Santa-Maria, Cesar, Stone, Steven, Lanchbury, Jerry S., Sahin, Aysegul A., Hortobagyi, Gabriel N. +1 more·2010·The American Journal of Pathology

Cited by (285)

Items 201–285 of 285

  1. De Novo Resistance Biomarkers to Anti-Her2 Therapies in Her2-Positive Breast Cancer
    Adela Madrid-Paredes, Marisa Cañadas‐Garre, Antonio Sánchez–Pozo, Miguel Ángel Calleja‐Hernández · 2015 · Pharmacogenomics
  2. Phospho-PRAS40Thr246 predicts trastuzumab response in patients with HER2-positive metastatic breast cancer
    Kai Yuan, Hongyan Wu, YULONG WANG, Hongqiang Chen, Mingwen Jiao, Rongzhan Fu · 2014 · Oncology Letters
  3. Primary systemic therapy in HER2-amplified breast cancer: a clinical review
    Mustafa Khasraw, Richard H. Bell · 2012 · Expert Review of Anticancer Therapy
  4. Addition of the Akt inhibitor triciribine overcomes antibody resistance in cells from ErbB2/Neu-positive/PTEN-deficient mammary tumors
    Qingfei Wang, Hui Ding, Baorui Liu, Shau-Hsuan Li, Ping Li, Hailiang Ge, Kui Zhang · 2014 · International Journal of Oncology
  5. Genomic alterations associated with HER2+ breast cancer risk and clinical outcome in response to trastuzumab
    Heena Singla, Raman Preet Kaur, Gowhar Shafi, Rajesh Vashistha, Raja Paramjeet Singh Banipal, Vinod Kumar, Anjana Munshi · 2018 · Molecular Biology Reports
  6. Everolimus‐containing therapy vs conventional therapy in the treatment of refractory breast cancer patients with PI3K/AKT/mTOR mutations: A retrospective study
    Zhanhong Chen, Yabing Zheng, Wen‐Ming Cao, Yuzi Zhang, Zhengyi Zhao, Guoqiang Wang, Jing Zhao, Shangli Cai, Xiying Shao, Jian Huang et al. · 2019 · Cancer Medicine
  7. HER2 Signaling in Breast Cancer
    Incheol Shin · 2021 · Advances in experimental medicine and biology
  8. FBXL10 contributes to the progression of nasopharyngeal carcinoma via involving in PI3K/mTOR pathway
    Yaoyao Ren, Long Wu, Xuelian Li, W. LI, Yonggong Yang, Min Zhang · 2015 · Neoplasma
  9. Insertional mutagenesis in a HER2-positive breast cancer model reveals ERAS as a driver of cancer and therapy resistance
    Gerjon J. Ikink, Mandy Boer, Elvira R. M. Bakker, Annabel Vendel-Zwaagstra, Chris Klijn, Jelle ten Hoeve, Jos Jonkers, Lodewyk F.A. Wessels, John Hilkens · 2018 · Oncogene
  10. Inactivating Amplified HER2: Challenges, Dilemmas, and Future Directions
    Mark M. Moasser · 2022 · Cancer Research
  11. Elevated V–ATPase Activity Following PTEN Loss Is Required for Enhanced Oncogenic Signaling in Breast Cancer
    Amro H. Mohammad, Sung-Hoon Kim, Nicholas Bertos, Wissal El-Assaad, Ipshita Nandi, Harvey W. Smith, Jieyi Yang, Owen J. Chen, Isabelle Gamache, Trisha Rao et al. · 2020 · Molecular Cancer Research
  12. Heregulin–ErbB3-Driven Tumor Growth Persists in PI3 Kinase Mutant Cancer Cells
    Defne Yarar, Johanna Lahdenranta, William Kubasek, Ulrik B. Nielsen, Gavin MacBeath · 2015 · Molecular Cancer Therapeutics
  13. The prognostic value of phosphatase and tensin homolog negativity in breast cancer: A systematic review and meta-analysis of 32 studies with 4393 patients
    Zu‐Yao Yang, Yuan-Yuan Yu, Jin-Qiu Yuan, Wei-Xi Shen, Dayong Zheng, Jinzhang Chen, Chen Mao, Jin-Ling Tang · 2016 · Critical Reviews in Oncology/Hematology
  14. Clinical Implications of Mutations in the PI3K Pathway in HER2+ Breast Cancer: Prognostic or Predictive?
    Ingrid A. Mayer · 2015 · Current Breast Cancer Reports
  15. Combined treatment with everolimus and fulvestrant reversed anti-HER2 resistance in a patient with refractory advanced breast cancer: a case report
    Bing Sun, Lijuan Ding, Shikai Wu, Santai Song, Xiangying Meng · 2016 · OncoTargets and Therapy
  16. Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancer
    Ebubekir Dirican, Mustafa Akkіprіk · 2017 · Tumor Biology
  17. Immunohistochemical prediction of lapatinib efficacy in advanced HER2-positive breast cancer patients
    Renata Duchnowska, for the Central and East European Oncology Group (CEEOG), Piotr Jan Wysocki, Konstanty Korski, Bogumiła Czartoryska-Arłukowicz, Anna Niwińska, Marlena Orlikowska, Barbara S. Radecka, Maciej Studziński, Regina Demlová et al. · 2015 · Oncotarget
  18. Gastric Carcinoma: Morphologic Classifications and Molecular Changes
    Sunmi Lee, Kyoung‐Mee Kim, Jae Yoon Ro · 2013 · InTech eBooks
  19. Immunohistochemistry for PTEN testing in HR +/HER2˗ metastatic breast cancer
    Nicola Fusco, Elena Guerini-Rocco, Isabella Castellano, Umberto Malapelle · 2025 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
  20. Metastatic human epidermal growth factor receptor 2-positive breast cancer: Management, challenges, and future directions
    Mohsin Soleja, Mothaffar Fahed Rimawi · 2016 · Current Problems in Cancer
  21. Effect of trastuzumab on Notch-1 signaling pathway in breast cancer SK-BR3 cells
    Ming Han, Huayu Deng, Rong Jiang · 2012 · Chinese Journal of Cancer Research
  22. Expression of PTEN‑long nephritis and its effect on renal inflammation
    Hui Wang, Qingxia Yu, Lin Wang, Yongwei Li, Mao Xie, Youyi Lu, Yupeng Cui · 2018 · Experimental and Therapeutic Medicine
  23. Increased MAPK1/3 Phosphorylation in Luminal Breast Cancer Related with PIK3CA Hotspot Mutations and Prognosis
    Diana E. Ramirez-Ardila, A. Mieke Timmermans, Jean Helmijr, John W.M. Martens, Els M.J.J. Berns, Maurice P.H.M. Jansen · 2017 · Translational Oncology
  24. PIK3CA: a Target or a Marker in Breast Cancers
    Maria Vittoria Dieci, Valentina Guarneri · 2015 · Current Breast Cancer Reports
  25. PTEN loss is not associated with trastuzumab resistance in metastatic breast cancer.
    Muharrem Kocar, Emine Baş Bozkurtlar, Ferhat Telli, Nazım Serdar Turhal, Handan Kaya, Hande Kocar, Fulden Yumuk · 2014 · PubMed
  26. Identifying Responders to Trastuzumab Therapy in Breast Cancer
    Anja Høegh Brügmann, Boe Sandahl Sørensen · 2011 · Future Oncology
  27. MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapy
    Benjamin C. Calhoun, Bryce Patrick Portier, Zhen Wang, Eugen C. Minca, George Thomas Budd, Christopher P. Lanigan, Raymond R. Tubbs, Larry E. Morrison · 2016 · BMC Cancer
  28. Biomarkers for the identification of recurrence in human epidermal growth factor receptor 2-positive breast cancer patients
    Giancarlo Pruneri, Giuseppina Bonizzi, Andrea Vingiani · 2016 · Current Opinion in Oncology
  29. Combined SRC inhibitor saracatinib and anti-ErbB2 antibody H2-18 produces a synergistic antitumor effect on trastuzumab-resistant breast cancer
    Lingfei Wang, Xiaojie Yu, Jian Dong, Yanchun Meng, Yang� Yang, Huajing Wang, Chao Wang, Yajun Zhang, Yirong Zhao, Jian Zhao et al. · 2016 · Biochemical and Biophysical Research Communications
  30. Extensive analysis of signaling pathway molecules in breast cancer: association with clinicopathological characteristics
    Rie Horii, Masaaki Matsuura, Shingo Dan, Masaru Ushijima, Natsue Uehiro, Akiko Ogiya, Naoko Honma, Yoshinori Ito, Takuji Iwase, Takao Yamori et al. · 2014 · International Journal of Clinical Oncology
  31. Biomarkers for Predicting Response to Anti- HER2 Agents
    Vinay Varadan, María L. Sandoval, Lyndsay N. Harris · 2016 · Advances in experimental medicine and biology
  32. HER2-Low Luminal Breast Carcinoma Is Not a Homogenous Clinicopathological and Molecular Entity
    Céline André, Aurélie Bertaut, Sylvain Ladoire, Isabelle Desmoulins, Clémentine Jankowski, Françoise Beltjens, Céline Charon‐Barra, Anthony Bergeron, Corentin Richard, Romain Boidot et al. · 2024 · Cancers
  33. TP53-positive clones are responsible for drug-tolerant persister and recurrence of HER2-positive breast cancer
    Hideki Watanabe, Hiroshi Nakagomi, Yosuke Hirotsu, Kenji Amemiya, Hitoshi Mochizuki, Masayuki Inoue, Ayako Kimura, Masao Omata · 2022 · Breast Cancer Research and Treatment
  34. BioPATH: A Biomarker Study in Asian Patients with HER2+ Advanced Breast Cancer Treated with Lapatinib and Other Anti-HER2 Therapy
    Sung‐Bae Kim, In‐Gu Do, Janice Wing Hang Tsang, Tae‐You Kim, Yoon Sim Yap, Gerardo H. Cornelio, Gyungyub Gong, Soonmyung Paik, Suee Lee, Ting‐Ying Ng et al. · 2019 · Cancer Research and Treatment
  35. Closing escape routes: inhibition of IL-8 signaling enhances the anti-tumor efficacy of PI3K inhibitors
    Ashish Juvekar, Gerburg M. Wulf · 2013 · Breast Cancer Research
  36. Trastuzumab-Resistance and Breast Cancer
    Milos Dokmanovic, Wen Jin · 2011 · InTech eBooks
  37. HER2 Signaling Network in Advanced Breast Cancer: Opportunities for Combination Therapies
    Nandini Dey, Brian R Leyland-Jones, Pradip K. De · 2016 · Cancer drug discovery and develogment/Cancer drug discovery and development
  38. Clinical value of isoform-specific detection and targeting of AKT1, AKT2 and AKT3 in breast cancer
    Gizeh Pérez‐Tenorio, Elin A. Karlsson, Olle Stål · 2014 · Breast Cancer Management
  39. A tipping-point for apoptosis following dual inhibition of HER2 signaling network by T-DM1 plus GDC-0980 maximizes anti-tumor efficacy.
    Nandini Dey, Jennifer Carlson Aske, Xiaoqian Lin, Yuliang Sun, Brian R Leyland-Jones, Lori S. Friedman, Pradip K. De · 2021 · PubMed Central
  40. Chemotherapy Agents in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: Time to Step Out of the Limelight
    NU Lin, Eric P. Winer · 2010 · Journal of Clinical Oncology
  41. Novel Therapies to Overcome HER2 Therapy Resistance in Breast Cancer
    Rita Nahta · 2019 · Resistance to targeted anti-cancer therapeutics
  42. Tyrosine Kinase Inhibitors
    Burcu Çakar, Erdem Göker · 2019 · Springer eBooks
  43. Signification clinique, diagnostique et intérêt théranostique des mutations du gène PIK3CA dans le cancer du sein
    Alexandre Harlé, Maëva Lion, Nicolas Lozano, Jean‐Louis Merlin · 2013 · Bulletin du Cancer
  44. Mathematical modelling of Her2 (ErbB2) PI3K/AKT signalling pathways during breast carcinogenesis to include PTPD2
    Bing Ji, Jiawei Bai, Luis A. J. Mur, Mengjia Zou, Jiwan Han, Rui Gao, Qing Zhen Yang · 2020 · AIMS Mathematics
  45. Trametinib alleviates lipopolysaccharide-induced acute kidney injury by inhibiting macrophage polarization through the PI3K/Akt pathway
    Yingqi Zeng, Wenjia Yuan, Chen Feng, Longkai Peng, Xubiao Xie, Fenghua Peng, Tengfang Li, Minjie Lin, Hedong Zhang, Helong Dai · 2025 · Transplant Immunology
  46. Prolonged survival after neoadjuvant chemotherapy related with specific molecular alterations in the patients with nonsmall-cell lung carcinoma
    Jelena M. Stojšić, Tijana Stanković, Sonja Stojković, Vedrana Milinković, Jelena Dinić, Zorica C. Milosevic, Zorka Milovanović, Nikola Tanić, Jasna Banković · 2014 · Experimental and Molecular Pathology
  47. Biweekly Combination of Trastuzumab, Docetaxel and Gemcitabine for HER2-Positive Metastatic Breast Cancer: Results of a Phase II GOIM Study
    Laura Orlando, Francesco Giotta, Vito Lorusso, Ferdinando De Vita, Gianfranco Filippelli, Evaristo Maiello, Ferdinando Riccardi, Giovanni Luigi Pappagallo, Palma Fedele, Nicola Gebbia et al. · 2014 · Future Oncology
  48. Resistance to HER2-Targeted Therapy
    Dirk Theile, Gal Lenz, Jamil Antonio Momand, Susan E. Kane · 2017 · Resistance to targeted anti-cancer therapeutics
  49. A Review and Meta-analysis on Trastuzumab Resistance in Patients with HER2+ Breast Cancer
    Alexandre Holzbach Júnior, Bernardo Perin Cima, Mari Dalva Staffen, Juliana Dal‐Ri Lindenau, Yara Costa Netto Muniz · 2023 · Mini-Reviews in Medicinal Chemistry
  50. A phase I study of AZD8186 in combination with docetaxel in patients with PTEN-mutated or PIK3CB-mutated advanced solid tumors
    Alison M. Schram, Naoko Takebe, Anna Chen, Qin C Zhou, Alexia E. Iasonos, J. Silber, M.E. Reynolds, S. Hussain, M. Gavriliuc, Lillian Mary Smyth et al. · 2025 · ESMO Open
  51. Novel syngeneic mouse mammary carcinoma cell lines from aggressive ErbB2/Neu-overexpressing/PTEN-deficient tumors
    Qingfei Wang, Hui Ding, HAI WANG, Ping Li, Baorui Liu, Kui Zhang · 2014 · Oncology Reports
  52. Targeted treatments of HER2-positive metastatic breast cancer: trastuzumab and beyond
    Dimitrios Zardavas, Lina Pugliano, Felipe Ades, Ivana Božović‐Spasojević, Marta Capelán, Evandro de Azambuja · 2012 · Breast Cancer Management
  53. Are mutations in K-RAS, BRAF and PIK3CA genes critical for response to adjuvant trastuzumab treatment in patients with HER-2 positive breast cancer?
    Anne Marie Bak Jylling, Anders Aamann Rasmussen, Erik Hugger Jakobsen, René dePont Christensen, Flemming Brandt Sørensen · 2014 · journal of cancer therapeutics and research
  54. Two-Temperature Formalin Fixation Preserves Activation States Efficiently
    David R. Chafin · 2015 · Recent results in cancer research/Recent Results in Cancer Research
  55. 68Ga-DTPA Anti-HER2 positron emission tomography/CT successfully predicts the overexpression of human epidermal growth factor receptor in lung metastases from breast cancer
    Quetzali Pitalúa-Cortés, Francisco O. García-Pérez, Yolanda Villaseñor‐Navarro, Fernando Ulises Lara-Medina, Juan Antonio Matus-Santos, Irma Soldevilla-Gallardo, Fany Iris Porras-Reyes, Víctor M. Pérez-Sánchez, Héctor Aquiles Maldonado-Martínez, Wendy B. Pérez-Báez et al. · 2017 · BJR|case reports
  56. The role of the phosphatase and tensin homolog status in predicting pathological complete response to neoadjuvant anti-HER2 therapies in HER2-positive primary breast cancer
    Chi Zhang, Ying Guo, Jiyu Li, Xingsong Tian, Xuening Duan · 2019 · Medicine
  57. Evaluation of PIK3CA Gene Mutations in Breast Cancer Patients Treated by Trastuzumab
    Elahe Nazeri, Mohammad Parniani, Asiie Olfatbakhsh, Safa Najafi, Marzieh Peyman, Behzad Karami, Sina Halvaei, Rezvan Esmaeili · 2023 · Archives of Breast Cancer
  58. The Role of Phosphoinositide 3-Kinase in Breast Cancer: An Overview
    Patricia Mucci LoRusso, Scott Anthony Boerner · 2010 · Clinical Breast Cancer
  59. Role of HER3 expression and PTEN loss in patients with HER2-overexpressing metastatic breast cancer (MBC) who received taxane plus trastuzumab treatment
    Francisco J. Esteva · 2014 · Breast Diseases A Year Book Quarterly
  60. Development of a machine learning model for predicting the expression of proteins associated with targeted therapy in endometrial cancer
    Chenwen Sun, Qianling Li, Yanan Huang, Yang Xia, M P Li, Xiucong Zhu, Jinke Zhu, Zhenhua Zhao · 2026 · Frontiers in Oncology
  61. PIK3CA Oncogenic Mutations in Neoadjuvant Treatments for Breast Cancer
    Giovanni Corso, Paolo Veronesi, Mattia Intra, Virgilio Sacchini, Viviana Enrica Galimberti · 2017 · Biomarkers in Medicine
  62. HER2 pozitif metastatik meme kanserinde PTEN, P27 ve PI3K ekspresyonunun prediktif ve prognostik önemi
    Sadi Kerem Okutur · 2011 · Istanbul Science University (Istanbul Bilim University)
  63. Participación del factor de necrosis tumoral alfa en la proliferación de carcinomas mamarios
    Martín A. Rivas · 2010 · Repositorio Digital Institucional de la Universidad de Buenos Aires (Universidad de Buenos Aires)
  64. Impact and Challenges in Assessing Tumor Purity by Next-Generation Sequencing
    Xiaoping Su, Gabriel G. Malouf, Francisco J. Esteva · 2013 · Springer eBooks
  65. Determining the Role of Autophagy in HER2/neu-Induced Mammary Tumor Dormancy and Recurrence
    Samantha Dwyer · 2013 · Scholarly Commons (University of Pennsylvania)
  66. Inmunofenotipos de cáncer de mama en pacientes jovenes (40 años o menores): estudio de la expresión inmunohistoquímica de la vía IGF1R, PTEN/Akt/mTOR
    María Planelles Asensio · 2015 · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)
  67. Estudio de adecuación de la prescripción de quimioterapia en cáncer de mama en un hospital de tercer nivel
    Ana María Alañón Pardo · 2014 · Tesis Doctorals en Xarxa (Consorci de Serveis Universitaris de Catalunya)
  68. Brèves de l’AERIO
    F.-G. Riet, C.-H. Canova, L. Feuvret, C. Bourgier · 2013 · ONCOLOGIE
  69. mTOR as a target in breast cancer: the emerging role of everolimus
    Michael Newton, Govardhanan Nagaiah, Jame Abraham · 2012 · Breast Cancer Management
  70. Anti-HER2 et cancers du sein métastatiques: Résultats cliniques des anti-HER2 actuels et futurs
    Séverine Guiu, Bruno P. Coudert, P. Fumoleau · 2012 · Springer eBooks
  71. Adverse reaction of a combined treatment for unresectable liver cancer
    Jianjun Ren, Tao Jiang, Rui Peng · 2013 · Open Medicine
  72. Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy
    Ali Sakhdari, Lloyd Hutchinson, Ediz F. Cosar · 2015 · Molecular pathology library
  73. Tyrosine Kinase Inhibitors
    Burcu Çakar, Erdem Göker · 2016 · Springer eBooks
  74. Novel biomarker approaches for improving therapeutic strategies in metastatic breast cancer
    Roberta Ferraldeschi, Gerhardt Attard · 2011 · CRC Press eBooks
  75. The Role of mTOR Inhibitors in Breast Cancer
    Philippe Georges Aftimos, Martine J Piccart · 2015 · Springer eBooks
  76. Phosphorylated S6 Kinase-1 as Predictive Marker of Lapatinib Efficacy in Human Epidermal Growth Factor Receptor 2-Positive Metastatic Breast Cancer Patients
    Eun-Byeol Ko, Min-Ki Seong, Hyang Suk Choi, Chan Sub Park, Ji Hye Choi, Jin‐Kyung Lee, Hyesil Seol, Hyun‐Ah Kim, Woo Chul Noh · 2017 · Journal of Breast Disease
  77. Brèves de l’AERIO
    Benjamin Verret, S. Dumont, Zahra Castel Ajgal, Johanna Wassermann · 2016 · ONCOLOGIE
  78. Targeting the EGFR family of receptor tyrosine kinases
    Siyuan Zhang, Dihua Yu · 2013 · Cambridge University Press eBooks
  79. Novel biomarker approaches for improving therapeutic strategies in metastatic breast cancer
    Roberta Ferraldeschi, Gerhardt Attard · 2011 · Informa Healthcare eBooks
  80. Methods for Estimating Long-Term Outcomes for Trastuzumab Deruxtecan in HER2-Positive Unresectable or Metastatic Breast Cancer After Two or More Anti-HER2 Therapies
    K. Dunton, Gerard Timmy Vondeling, Elizabeth Hancock, Margaret Petrou, Oliver Burn, Abby Paine · 2022 · Targeted Oncology
  81. Next-Generation Sequencing-Based Analysis of Clinical and Pathological Features of PIK3CA-Mutated Breast Cancer
    Jolanta Smok-Kalwat, Grzegorz Chmielewski, Rafał Stando, Jacek Sadowski, Paweł Macek, Artur Kowalik, Ewelina Nowak-Ozimek, Stanisław S. Góźdź · 2023 · Diagnostics
  82. HER2 targeted therapy resistance in breast cancer: from molecular landscape to clinical aspects
    Hongyan Zhang, Ding Ma, Fubing Li, Zhimin Shao, Ceshi Chen · 2026 · Science China Life Sciences
  83. HER2 in Cancer Biology and Precision Oncology: Gene Structure, Signaling Pathways and Targeted Therapeutic Strategies
    Viorica Elena Radoi · 2026 · IntechOpen eBooks
  84. Comment augmenter la performance des médicaments anti-HER?
    Florence Dalenc, Yann Bergé, Henri Hubert Roche · 2012 · Springer eBooks
  85. Novel Role of ErbB-2 in Inhibition of Jagged-1-Mediated Trans-Activation of Notch in Breast Cancer
    Kinnari Pandya · 2013 · Loyola eCommons (Loyola University of Chicago)