PTEN, PIK3CA, p-AKT, and p-p70S6K Status
Esteva, Francisco J., Guo, Hua, Zhang, Siyuan, Santa-Maria, Cesar, Stone, Steven, Lanchbury, Jerry S., Sahin, Aysegul A., Hortobagyi, Gabriel N. +1 more·2010·The American Journal of Pathology
Cited by (285)
Items 201–285 of 285
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- Clinical Implications of Mutations in the PI3K Pathway in HER2+ Breast Cancer: Prognostic or Predictive?Ingrid A. Mayer · 2015 · Current Breast Cancer Reports
- Combined treatment with everolimus and fulvestrant reversed anti-HER2 resistance in a patient with refractory advanced breast cancer: a case reportBing Sun, Lijuan Ding, Shikai Wu, Santai Song, Xiangying Meng · 2016 · OncoTargets and Therapy
- Phosphatidylinositol 3-kinase regulatory subunit 1 and phosphatase and tensin homolog as therapeutic targets in breast cancerEbubekir Dirican, Mustafa Akkіprіk · 2017 · Tumor Biology
- Immunohistochemical prediction of lapatinib efficacy in advanced HER2-positive breast cancer patientsRenata Duchnowska, for the Central and East European Oncology Group (CEEOG), Piotr Jan Wysocki, Konstanty Korski, Bogumiła Czartoryska-Arłukowicz, Anna Niwińska, Marlena Orlikowska, Barbara S. Radecka, Maciej Studziński, Regina Demlová et al. · 2015 · Oncotarget
- Gastric Carcinoma: Morphologic Classifications and Molecular ChangesSunmi Lee, Kyoung‐Mee Kim, Jae Yoon Ro · 2013 · InTech eBooks
- Immunohistochemistry for PTEN testing in HR +/HER2˗ metastatic breast cancerNicola Fusco, Elena Guerini-Rocco, Isabella Castellano, Umberto Malapelle · 2025 · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
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- Effect of trastuzumab on Notch-1 signaling pathway in breast cancer SK-BR3 cellsMing Han, Huayu Deng, Rong Jiang · 2012 · Chinese Journal of Cancer Research
- Expression of PTEN‑long nephritis and its effect on renal inflammationHui Wang, Qingxia Yu, Lin Wang, Yongwei Li, Mao Xie, Youyi Lu, Yupeng Cui · 2018 · Experimental and Therapeutic Medicine
- Increased MAPK1/3 Phosphorylation in Luminal Breast Cancer Related with PIK3CA Hotspot Mutations and PrognosisDiana E. Ramirez-Ardila, A. Mieke Timmermans, Jean Helmijr, John W.M. Martens, Els M.J.J. Berns, Maurice P.H.M. Jansen · 2017 · Translational Oncology
- PIK3CA: a Target or a Marker in Breast CancersMaria Vittoria Dieci, Valentina Guarneri · 2015 · Current Breast Cancer Reports
- PTEN loss is not associated with trastuzumab resistance in metastatic breast cancer.Muharrem Kocar, Emine Baş Bozkurtlar, Ferhat Telli, Nazım Serdar Turhal, Handan Kaya, Hande Kocar, Fulden Yumuk · 2014 · PubMed
- Identifying Responders to Trastuzumab Therapy in Breast CancerAnja Høegh Brügmann, Boe Sandahl Sørensen · 2011 · Future Oncology
- MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapyBenjamin C. Calhoun, Bryce Patrick Portier, Zhen Wang, Eugen C. Minca, George Thomas Budd, Christopher P. Lanigan, Raymond R. Tubbs, Larry E. Morrison · 2016 · BMC Cancer
- Biomarkers for the identification of recurrence in human epidermal growth factor receptor 2-positive breast cancer patientsGiancarlo Pruneri, Giuseppina Bonizzi, Andrea Vingiani · 2016 · Current Opinion in Oncology
- Combined SRC inhibitor saracatinib and anti-ErbB2 antibody H2-18 produces a synergistic antitumor effect on trastuzumab-resistant breast cancerLingfei Wang, Xiaojie Yu, Jian Dong, Yanchun Meng, Yang� Yang, Huajing Wang, Chao Wang, Yajun Zhang, Yirong Zhao, Jian Zhao et al. · 2016 · Biochemical and Biophysical Research Communications
- Extensive analysis of signaling pathway molecules in breast cancer: association with clinicopathological characteristicsRie Horii, Masaaki Matsuura, Shingo Dan, Masaru Ushijima, Natsue Uehiro, Akiko Ogiya, Naoko Honma, Yoshinori Ito, Takuji Iwase, Takao Yamori et al. · 2014 · International Journal of Clinical Oncology
- Biomarkers for Predicting Response to Anti- HER2 AgentsVinay Varadan, María L. Sandoval, Lyndsay N. Harris · 2016 · Advances in experimental medicine and biology
- HER2-Low Luminal Breast Carcinoma Is Not a Homogenous Clinicopathological and Molecular EntityCéline André, Aurélie Bertaut, Sylvain Ladoire, Isabelle Desmoulins, Clémentine Jankowski, Françoise Beltjens, Céline Charon‐Barra, Anthony Bergeron, Corentin Richard, Romain Boidot et al. · 2024 · Cancers
- TP53-positive clones are responsible for drug-tolerant persister and recurrence of HER2-positive breast cancerHideki Watanabe, Hiroshi Nakagomi, Yosuke Hirotsu, Kenji Amemiya, Hitoshi Mochizuki, Masayuki Inoue, Ayako Kimura, Masao Omata · 2022 · Breast Cancer Research and Treatment
- BioPATH: A Biomarker Study in Asian Patients with HER2+ Advanced Breast Cancer Treated with Lapatinib and Other Anti-HER2 TherapySung‐Bae Kim, In‐Gu Do, Janice Wing Hang Tsang, Tae‐You Kim, Yoon Sim Yap, Gerardo H. Cornelio, Gyungyub Gong, Soonmyung Paik, Suee Lee, Ting‐Ying Ng et al. · 2019 · Cancer Research and Treatment
- Closing escape routes: inhibition of IL-8 signaling enhances the anti-tumor efficacy of PI3K inhibitorsAshish Juvekar, Gerburg M. Wulf · 2013 · Breast Cancer Research
- Trastuzumab-Resistance and Breast CancerMilos Dokmanovic, Wen Jin · 2011 · InTech eBooks
- HER2 Signaling Network in Advanced Breast Cancer: Opportunities for Combination TherapiesNandini Dey, Brian R Leyland-Jones, Pradip K. De · 2016 · Cancer drug discovery and develogment/Cancer drug discovery and development
- Clinical value of isoform-specific detection and targeting of AKT1, AKT2 and AKT3 in breast cancerGizeh Pérez‐Tenorio, Elin A. Karlsson, Olle Stål · 2014 · Breast Cancer Management
- A tipping-point for apoptosis following dual inhibition of HER2 signaling network by T-DM1 plus GDC-0980 maximizes anti-tumor efficacy.Nandini Dey, Jennifer Carlson Aske, Xiaoqian Lin, Yuliang Sun, Brian R Leyland-Jones, Lori S. Friedman, Pradip K. De · 2021 · PubMed Central
- Chemotherapy Agents in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: Time to Step Out of the LimelightNU Lin, Eric P. Winer · 2010 · Journal of Clinical Oncology
- Novel Therapies to Overcome HER2 Therapy Resistance in Breast CancerRita Nahta · 2019 · Resistance to targeted anti-cancer therapeutics
- Tyrosine Kinase InhibitorsBurcu Çakar, Erdem Göker · 2019 · Springer eBooks
- Signification clinique, diagnostique et intérêt théranostique des mutations du gène PIK3CA dans le cancer du seinAlexandre Harlé, Maëva Lion, Nicolas Lozano, Jean‐Louis Merlin · 2013 · Bulletin du Cancer
- Mathematical modelling of Her2 (ErbB2) PI3K/AKT signalling pathways during breast carcinogenesis to include PTPD2Bing Ji, Jiawei Bai, Luis A. J. Mur, Mengjia Zou, Jiwan Han, Rui Gao, Qing Zhen Yang · 2020 · AIMS Mathematics
- Trametinib alleviates lipopolysaccharide-induced acute kidney injury by inhibiting macrophage polarization through the PI3K/Akt pathwayYingqi Zeng, Wenjia Yuan, Chen Feng, Longkai Peng, Xubiao Xie, Fenghua Peng, Tengfang Li, Minjie Lin, Hedong Zhang, Helong Dai · 2025 · Transplant Immunology
- Prolonged survival after neoadjuvant chemotherapy related with specific molecular alterations in the patients with nonsmall-cell lung carcinomaJelena M. Stojšić, Tijana Stanković, Sonja Stojković, Vedrana Milinković, Jelena Dinić, Zorica C. Milosevic, Zorka Milovanović, Nikola Tanić, Jasna Banković · 2014 · Experimental and Molecular Pathology
- Biweekly Combination of Trastuzumab, Docetaxel and Gemcitabine for HER2-Positive Metastatic Breast Cancer: Results of a Phase II GOIM StudyLaura Orlando, Francesco Giotta, Vito Lorusso, Ferdinando De Vita, Gianfranco Filippelli, Evaristo Maiello, Ferdinando Riccardi, Giovanni Luigi Pappagallo, Palma Fedele, Nicola Gebbia et al. · 2014 · Future Oncology
- Resistance to HER2-Targeted TherapyDirk Theile, Gal Lenz, Jamil Antonio Momand, Susan E. Kane · 2017 · Resistance to targeted anti-cancer therapeutics
- A Review and Meta-analysis on Trastuzumab Resistance in Patients with HER2+ Breast CancerAlexandre Holzbach Júnior, Bernardo Perin Cima, Mari Dalva Staffen, Juliana Dal‐Ri Lindenau, Yara Costa Netto Muniz · 2023 · Mini-Reviews in Medicinal Chemistry
- A phase I study of AZD8186 in combination with docetaxel in patients with PTEN-mutated or PIK3CB-mutated advanced solid tumorsAlison M. Schram, Naoko Takebe, Anna Chen, Qin C Zhou, Alexia E. Iasonos, J. Silber, M.E. Reynolds, S. Hussain, M. Gavriliuc, Lillian Mary Smyth et al. · 2025 · ESMO Open
- Novel syngeneic mouse mammary carcinoma cell lines from aggressive ErbB2/Neu-overexpressing/PTEN-deficient tumorsQingfei Wang, Hui Ding, HAI WANG, Ping Li, Baorui Liu, Kui Zhang · 2014 · Oncology Reports
- Targeted treatments of HER2-positive metastatic breast cancer: trastuzumab and beyondDimitrios Zardavas, Lina Pugliano, Felipe Ades, Ivana Božović‐Spasojević, Marta Capelán, Evandro de Azambuja · 2012 · Breast Cancer Management
- Are mutations in K-RAS, BRAF and PIK3CA genes critical for response to adjuvant trastuzumab treatment in patients with HER-2 positive breast cancer?Anne Marie Bak Jylling, Anders Aamann Rasmussen, Erik Hugger Jakobsen, René dePont Christensen, Flemming Brandt Sørensen · 2014 · journal of cancer therapeutics and research
- Two-Temperature Formalin Fixation Preserves Activation States EfficientlyDavid R. Chafin · 2015 · Recent results in cancer research/Recent Results in Cancer Research
- 68Ga-DTPA Anti-HER2 positron emission tomography/CT successfully predicts the overexpression of human epidermal growth factor receptor in lung metastases from breast cancerQuetzali Pitalúa-Cortés, Francisco O. García-Pérez, Yolanda Villaseñor‐Navarro, Fernando Ulises Lara-Medina, Juan Antonio Matus-Santos, Irma Soldevilla-Gallardo, Fany Iris Porras-Reyes, Víctor M. Pérez-Sánchez, Héctor Aquiles Maldonado-Martínez, Wendy B. Pérez-Báez et al. · 2017 · BJR|case reports
- The role of the phosphatase and tensin homolog status in predicting pathological complete response to neoadjuvant anti-HER2 therapies in HER2-positive primary breast cancerChi Zhang, Ying Guo, Jiyu Li, Xingsong Tian, Xuening Duan · 2019 · Medicine
- Evaluation of PIK3CA Gene Mutations in Breast Cancer Patients Treated by TrastuzumabElahe Nazeri, Mohammad Parniani, Asiie Olfatbakhsh, Safa Najafi, Marzieh Peyman, Behzad Karami, Sina Halvaei, Rezvan Esmaeili · 2023 · Archives of Breast Cancer
- The Role of Phosphoinositide 3-Kinase in Breast Cancer: An OverviewPatricia Mucci LoRusso, Scott Anthony Boerner · 2010 · Clinical Breast Cancer
- Role of HER3 expression and PTEN loss in patients with HER2-overexpressing metastatic breast cancer (MBC) who received taxane plus trastuzumab treatmentFrancisco J. Esteva · 2014 · Breast Diseases A Year Book Quarterly
- Development of a machine learning model for predicting the expression of proteins associated with targeted therapy in endometrial cancerChenwen Sun, Qianling Li, Yanan Huang, Yang Xia, M P Li, Xiucong Zhu, Jinke Zhu, Zhenhua Zhao · 2026 · Frontiers in Oncology
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- HER2 pozitif metastatik meme kanserinde PTEN, P27 ve PI3K ekspresyonunun prediktif ve prognostik önemiSadi Kerem Okutur · 2011 · Istanbul Science University (Istanbul Bilim University)
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