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Acute ingestion of neuromuscular enhancement supplements do not improve power output, work capacity, and cognition
Abstract
Background Improving motor unit recruitment and function is trainable and positively affects performance. Evidence suggests that supplementation of choline, uridine, and docosahexaenoic acid (DHA) may also enhance neuromuscular function. The purpose of this study was to assess the influence of acute ingestion of these supplements on anaerobic exercise performance and cognition. Methods Twenty college-aged trained males (21.2±1.4 years, 181.2±6.1 cm, 94.4±20.5 kg, and 15.9±6.6% body fat) received the supplements (SUPP: 500 mg alpha glycerophosphocholine [AGPC], 250 mg uridine-5'-monophosphate, and 1500 mg DHA) or a placebo (PLA) in a randomized cross-over study design. All participants completed one familiarization and two experimental testing sessions, consisting of a warm up, vertical jump assessment, 61-kg bench press rep max, and completion of the ImPACT neural cognition test. In the two testing sessions, participants received, in random order, either the SUPP or a PLA, 90 minutes before testing. Results There was no significant difference between SUPP and PLA on exercise performance or neural cognition (P>0.05). Conclusions The results of this study indicated no benefit from acute ingestion of a DHA, uridine, and choline supplement versus a placebo on anaerobic performance or cognition. It is likely that acute ingestion of these supplements did not provide the necessary elements to increase acetylcholine concentration or number of dendritic spines, rather ingestion for a…
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A single day of supplementation with an A-GPC combination exerted no impact on cognition or physical performance outcomes in college-aged males.
“The results from this study also indicated that a single day of supplementation exerted no impact on their outcomes.”
From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [11]
Acute supplementation with an A-GPC combination did not impact vertical jump performance or maximal bench press repetitions in college-aged males.
“reported that supplementation did not impact vertical jump performance or the maximal number of bench press repetitions completed.”
From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [11]
The majority of studies in healthy individuals have failed to highlight cognitive benefits of A-GPC.
“Research in healthy populations, however, is scant, and, to date, the majority of these studies have failed to highlight cognitive benefits in healthy individuals [11,12].”
From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [11]
Previous investigations using this population were unable to identify such changes [11,12], while studies involving older and clinically compromised populations [1] have reported the ability of A-GPC to positively impact cognitive performance.
“Previous investigations using this population were unable to identify such changes [11,12], while studies involving older and clinically compromised populations [1] have reported the ability of A-GPC to positively impact cognitive performance.”
From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [11]
The higher A-GPC dosage (HD: 630 mg) during the present study was higher than the dosages provided during both the Parker (200 mg and 400 mg) and Bunn (500 mg) investigations [11,12].
“The higher A-GPC dosage (HD: 630 mg) during the present study was higher than the dosages provided during both the Parker (200 mg and 400 mg) and Bunn (500 mg) investigations [11,12]”
From Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men (2024) · cites this paper as [11]
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Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men
Kerksick, C. M. (2024) · Nutrients · doi:10.3390/nu16234240 · Cited by 8
“Research in healthy populations, however, is scant, and, to date, the majority of these studies have failed to highlight cognitive benefits in healthy individuals [11,12].”
Influential
Metadata
- Authors
- Bunn, J. A., Crossley, A., & Timiney, M. D.
- Affiliations
- Campbell University (US)
- High Point University (US)
- ORCID
- Bunn, Jennifer A.
- Venue
- The Journal of Sports Medicine and Physical Fitness
- Publisher
- Edizioni Minerva Medica
- Published
- 2018-06
- Volume
- 58
- Issue
- 7-8
- Pages
- 974-979
- ISSN
- 0022-4707 (ISSN-L)
- 1827-1928
- OpenAlex
- W2958534569
- Cited by
- 6
- References
- 0
- Citations by year
- 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1
- FWCI
- 0.27
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Sports Medicine and Physical Fitness (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Keywords
- uridine 5'-monophosphate, docosahexaenoic acid, choline supplementation, anaerobic exercise performance, vertical jump, bench press, cognitive performance, impact testing, acetylcholine, motor unit recruitment, trained men
- MeSH terms
- Choline, Cognition, Docosahexaenoic Acids, Double-Blind Method, Humans, Male, Uridine, Exercise, Cross-Over Studies, Dietary Supplements, Young Adult, Performance-Enhancing Substances, Sports Nutritional Physiological Phenomena
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