A Controlled Evaluation of Albendazole Against Natural Infections with Fasciola hepatica and Fascioloides magna in Cattle
Abstract
SUMMARY: Albendazole administered to cattle at doses of 45, 35, 25, and 15 mg/kg of body weight reduced the number of viable Fasciola hepatica adults by 99.8%, 97.6%, 97.6%, and 95.7%, F hepatica immatures by 100%, 98.6%, 98.6% and 91.9% and Fascioloides magna by 96.5%, 99.1%, 94.0%, and 94.0%, respectively. Statistical evaluation by one-way analysis of variance, showed significant (P < 0.05) differences in burdens of each fluke species between treated and untreated cattle, but differences in efficacy between any two of the four drug doses were not significant. Signs of toxicosis were not observed between the time of drug administration and slaughter 7 to 10 days later.
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Efficacy of albendazole was first documented in the 1970s-1980s against fascioliasis in animals, including cattle and sheep.
“The efficacy of albendazole was first documented in the 1970s-1980s against fascioliasis in animals, including cattle and sheep [1,254,255]”
From Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update (2021) · cites this paper as [254]
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Albendazole and Mebendazole as Anti-Parasitic and Anti-Cancer Agents: an Update
Chai, J.-Y., Jung, B.-K., & Hong, S.-J. (2021) · The Korean Journal of Parasitology · doi:10.3347/kjp.2021.59.3.189 · Cited by 286 · see citing works
- Authors
- Ronald, N. C., Craig, T. M., & Bell, R. R.
- Affiliations
- Texas A&M University (US)
- ORCID
- Craig, T. M.
- Venue
- American Journal of Veterinary Research
- Published
- 1979-09-01
- Volume
- 40
- Issue
- 9
- Pages
- 1299-1300
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W4409139312
- Cited by
- 14
- References
- 0
- Citations by year
- 2021: 1 · 2016: 1
- FWCI
- 2.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Health Sciences › Veterinary › Small Animals › Helminth infection and control
- Life Sciences › Agricultural and Biological Sciences › Insect Science › Mollusks and Parasites Studies
- Health Sciences › Veterinary › Small Animals › Veterinary Pharmacology and Anesthesia
- Keywords
- albendazole, Fasciola hepatica, Fascioloides magna, fascioliasis, fascioloidiasis, cattle, anthelmintic efficacy, dose-response relationship, fluke burden, drug toxicity
- MeSH terms
- Animals, Anthelmintics, Benzimidazoles, Cattle, Cattle Diseases, Fasciola hepatica, Fascioliasis, Trematoda
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