The DOI matches its Crossref record.
Effects of human alpha interferon on experimentally induced equine herpesvirus-1 infection in horses.
Abstract
The immunotherapeutic effect of low-dose human alpha interferon on viral shedding and clinical disease was evaluated in horses inoculated with equine herpesvirus-1 (EHV-1). Eighteen clinically healthy weanling horses, 5 to 7 months old, were allotted to 3 equal groups. Two groups were treated orally with human alpha-2a interferon (0.22 or 2.2 U/kg of body weight), on days 2 and 1 before inoculation with EHV-1, the day of inoculation, and again on postinoculation day 1. The horses of the remaining group were given a placebo orally on the same days. The horses were monitored daily for changes in body temperature and for clinical signs of respiratory tract disease. Blood and nasal swab specimens were collected daily for virus isolation. Blood was also collected at intervals throughout the monitoring period for evaluation of CBC, serum IgG and IgM concentrations, and antibody titers to EHV-1. Febrile responses, nasal discharge, viral shedding, changes in CBC, and an increase in antibody titers to EHV-1 were noticed in all horses after inoculation. There was no significant difference (P greater than 0.05) in mean values of the factors measured between treatment and control groups.
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“So far, the low dose administration of human type I IFN to experimentally EHV-1 infected horses did not show significant decrease in viral shedding and clinical disease (Seahorn et al., 1990).”
From The Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1 (2021) · cites this paper as Seahorn et al., 1990
Citations
Cited by
Systemic effects of interferons after oral administration in animals and humans
Cummins, J. Μ., Krakowka, G. S., & Thompson, C. G. (2005) · American Journal of Veterinary Research · doi:10.2460/ajvr.2005.66.164 · Cited by 63
Self-citationThe Pathogenesis and Immune Evasive Mechanisms of Equine Herpesvirus Type 1
Laval, K., Poelaert, K. C. K., Van Cleemput, J., Zhao, J., Vandekerckhove, A. P., Gryspeerdt, A. C., Garré, B., van der Meulen, K., Baghi, H. B., Dubale, H. N., et al. (2021) · Frontiers in Microbiology · doi:10.3389/fmicb.2021.662686 · Cited by 54
Equine Herpesvirus 1 and 4 Respiratory Disease in the Horse
Mollat, W. H., & Pusterla, N. (2006) · Clinical techniques in equine practice · doi:10.1053/j.ctep.2006.03.014 · Cited by 31
Rush, B. R., & Flaminio, M. J. B. F. (2000) · Veterinary Clinics of North America Equine Practice · doi:10.1016/s0749-0739(17)30126-8 · Cited by 27
Wagner, B., Hillegas, J. M., Flaminio, M. J. B. F., et al. (2008) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2008.05.016 · Cited by 23
“In contrast, human rIFN-a prophylaxis in weanlings experimentally infected with EHV-1 did not reduce viral shedding or clinical signs of disease (Seahorn et al., 1990).”
Result
Metadata
- Authors
- Seahorn, T. L., Carter, G. K., Martens, J. G., Crandell, R. A., Martin, M. T., Scrutchfield, W. L., Cummins, J. M., & Martens, R. J.
- Affiliations
- Texas A&M University (US)
- From the Department of Large Animal Medicine and Surgery (Seahorn, Carter, Martin, Scrutchfield, R. Martens) and the Department of Medical Microbiology and Immunology (J. Martens), College of Veterinary Medicine, Texas A&M University, College Station, TX 77843, The Texas Veterinary' Medical Diagnostic Laboratory, College Station, TX 77841 (Crandell), and Amarillo Cell Culture Co, Amarillo, TX 79160 (Cummins).
- Venue
- American Journal of Veterinary Research
- Published
- 1990-12-01
- Volume
- 51
- Issue
- 12
- Pages
- 2006-2010
- ISSN
- 0002-9645 (ISSN-L)
- OpenAlex
- W1618383799
- Cited by
- 18
- References
- 0
- Citations by year
- 2024: 3 · 2023: 1 · 2021: 1 · 2013: 1
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Veterinary Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Herpesvirus Infections and Treatments
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Virus Infections Studies
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Keywords
- equine herpesvirus 1, horses, viral shedding, respiratory diseases, antibody titers, IgM and IgG antibodies, weanling horses, experimental infection
- MeSH terms
- Interferon alpha-2, Animals, Body Temperature, Herpesvirus 1, Equid, Hematologic Tests, Herpesviridae Infections, Horse Diseases, Horses, Humans, Leukocyte Count, Nasal Mucosa, Recombinant Proteins, Interferon-alpha
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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