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Performance of a Borrelia burgdorferi bacterin in borreliosis-endemic areas
Open accessAbstract
The safety and efficacy of a commercially available Borrelia burgdorferi bacterin were examined under field conditions in 1,969 dogs that received a total of 4,033 doses of bacterin during a 20-month period. For comparison, 4,498 dogs that were not vaccinated also were evaluated. All dogs were examined at 1 of 3 veterinary practices in borreliosis-endemic areas. Owners of all dogs were educated about the benefits of and methods for avoiding infected ticks. Vaccination was found to be safe regardless of previous exposure to B burgdorferi or history of borreliosis. Thirty-eight (1.9%) of the 1,969 dogs had minor reactions; 1 of these dogs had a reaction after the first and second doses of B burgdorferi bacterin. Reactions resolved without complications immediately or within 72 hours after vaccination. Cumulative incidence of borreliosis was 1.0% (20/1,969) in vaccinated dogs and 4.7% (211/4,498) in nonvaccinated dogs. Preventable fraction, a measure of the reduction of incidence of disease in vaccinated dogs vs nonvaccinated dogs, was 78%. Preventable fraction in dogs that were seropositive prior to vaccination (ie, previously exposed to B burgdorferi) was 58% and in dogs that were seronegative prior to vaccination (ie, without evidence of prior exposure to B burgdorferi) was 86%. This suggested that, in borreliosis-endemic areas, dogs may be most effectively protected by vaccinating them when they are young and before they are exposed to infected ticks, and that in areas where borreliosis is not endemic, it may be useful to initiate vaccination programs so that dogs will be protected prior to exposure to infected ticks.
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“One observational study reported that 38 of 1969 dogs (1.9%) had minor reactions, and that 1 dog had a reaction after the 2nd vaccine dose; all reactions were reported to have resolved without complications by 72 hours after vaccination.28”
From Efficacy of Borrelia burgdorferi vaccine in dogs in North America: A systematic review and meta-analysis (2019) · cites this paper as [28]
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- [2]2. Levy SA. Lyme borreliosis in domestic animals. Conn Med 1989;53:352-353.
- [3]3. Lissman BA. Lyme disease in small animals. N J Med 1990;87:573-574. - Canine Pract 1992;2:5-13. - bodies to Borrelia burgdorferi in dogs and subsequent development of limb/joint borreliosis. J Am Vet Med Assoc 1992; 200:344-347.
- [6]6. Magnarelli LA, Anderson JF, Schreir AB, et al. Clinical and serologic studies of canine borreliosis. J Am Vet Med Assoc 1987;191:1089-1094.
- [7]7. Grauer GF, Burgess EC, Cooley AJ, et al. Renal lesions associated with Borrelia burgdorferi infection in a dog. J Am Vet Med Assoc1988;193:237-238.
- [9]9. Bosler EM, Cohen DP, Schulze TL, et al. Host responses to Borrelia burgdorferi in dogs and horses. Ann NY Acad Sci1988;539:221-234.
- [8]8. Levy SA, Duray PH. Complete heart block in a dog seropositive for Borrelia burgdorferi: similarity to human Lyme carditis. J Vet Intern Med 1988;2:138-144.
- [10]10. Johnston RC, Kodner C, Russel M. Passive immunization of hamsters against experimental infection with the Lyme disease spirochete. Infect Immun 1986;53:713-714.
- [11]11. Johnson RC, Kodner C, Russell M. Active immunization of hamsters against experimental infection with Borrelia burgdorferi. Infect Immun 1986;54:897-898.
- [12]12. Fikrig E, Barthold S, Kantor F, et al. Protection of mice against the Lyme disease agent by immunization with recombinant Osp A. Science 1990;250:553–556.
- [13]13. Schaible UE, Kramer MD, Eichman K, et al. Monoclonal antibodies specific for the outer surface protein A (Osp A) of Borrelia burgdorferi prevent Lyme borreliosis in severe combined immunodeficiency (scid) mice. Proc Natl Acad Sci USA 1990;87:3768-3772.
- [14]14. Chu H-J, Chavez LG, Blumer B, et al. Immunogenicity and efficacy study of a commercial Borrelia burgdorferi bacterin. J Am Vet Med Assoc 1992;201:403-411.
- [16]16. Magnarelli LA, Meegan JM, Anderson JF, et al. Comparison of an indirect fluorescent antibody test with an enzymelinked immunosorbent assay for serological studies of Lyme disease. J Clin Microbiol 1984;20:181-184.
- [17]17. Greene RT. An update on the serodiagnosis of canine Lyme borreliosis. J Vet Int Med 1990;4:167-171.
- [18]18. Kleinbaum DG, Kupper IL, Morgenstern H. Epidemiologic research: principles and quantitative methods. New York: Van Nostrand Reinhold Co, 1982;165,286.
- [19]19. Magnarelli LA, Anderson JF, Schreir AB. Persistence of antibodies to Borrelia burgdorferi in dogs of New York and Connecticut. J Am Vet Med Assoc 1990;196:1064-1068.
- [20]20. Greene RT, Walker RL, Nicholson WL, et al. Immunoblot analysis of immunoglobulin G response to the Lyme disease agent (Borrelia burgdorferi) in experimentally and naturally exposed dogs. J Clin Microbiol 1988;26:648-653.
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“Th is rash is oft en accompanied by fl u-like symptoms (11) and, if the infection is left untreated, the spirochetes can then cause additional complications, such as arthritis, carditis, or neurologic disease.”
Background
Metadata
- Authors
- Levy, S. A., Lissman, B. A., & Ficke, C. M.
- Affiliations
- From Durham Veterinary Hospital, 178 Parmelee Hill Rd, Durham, CT 06422 (Levy); Sachem Animal Hospital, 227 Union Ave, Holbrook, NY 11741 (Lissman); and Chester Veterinary Clinic, 264 Middlesex Turnpike, Chester, CT 06412 (Ficke).
- Venue
- Journal of the American Veterinary Medical Association
- Published
- 1993-06-01
- Volume
- 202
- Issue
- 11
- Pages
- 1834-1838
- ISSN
- 0003-1488 (ISSN-L)
- OpenAlex
- W4390377773
- Cited by
- 52
- References
- 0
- Citations by year
- 2026: 1 · 2024: 1 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 2 · 2016: 1 · 2015: 3 · 2013: 2 · 2012: 2
- FWCI
- 2.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Veterinary Medical Association (publishedVersion)
- PubMed (publishedVersion)
- PubMed
- Topics
- Life Sciences › Immunology and Microbiology › Parasitology › Vector-borne infectious diseases
- Health Sciences › Medicine › Infectious Diseases › Brucella: diagnosis, epidemiology, treatment
- Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
- Keywords
- Borrelia burgdorferi, bacterin vaccine, vaccine safety, vaccine efficacy, preventable fraction, seropositivity, tick exposure, vaccination timing, vaccine adverse reactions
- MeSH terms
- Animals, Antibodies, Bacterial, Bacterial Vaccines, Dog Diseases, Dogs, Female, Injections, Intramuscular, Lyme Disease, Male, Vaccination, Borrelia burgdorferi Group
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