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Cited by 18Contact Dermatitis and AllergiesDrug-Induced Adverse ReactionsImmunotoxicology and immune responses

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Erythema multiforme major and disseminated intravascular coagulation in a dog following application of a d-limonene-based insecticidal dip

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Rosenbaum, Michele R., Kerlin, Roy L.·1995·Journal of the American Veterinary Medical Association
DOI 10.2460/javma.1995.207.10.1315
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Abstract

Erythema multiforme major and disseminated intravascular coagulation developed in a dog 24 hours after exposure to a d-limonene-based insecticidal dip. Clinical signs included severe lethargy and weakness, ulceration of the oral mucosa, and erythematous serpiginous, annular, and arciform lesions on the head, trunk, and limbs. Clinicopathologic abnormalities included leukocytosis with neutrophilia, normocytic normochromic anemia, thrombocytopenia, prolongation of prothrombin and partial thromboplastin times, increased fibrin degradation products, hypoproteinemia, hyponatremia, hypochloremia, azotemia, high serum alanine aminotransferase and alkaline phosphatase activities, and high serum bilirubin concentration. Despite intensive supportive care, the dog developed severe intrathoracic and abdominal hemorrhage and died. Necropsy revealed severe diffuse epidermal necrosis and widespread hemorrhage within organs. Insecticidal dips containing d-limonene have the potential to induce various toxic effects, including, possibly, erythema multiforme major, and should be used cautiously.

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Metadata

Authors
Rosenbaum, M. R., & Kerlin, R. L.
Affiliations
University of Pennsylvania (US)
Venue
Journal of the American Veterinary Medical Association
Publisher
American Veterinary Medical Association (AVMA)
Published
1995-11-15
Volume
207
Issue
10
Pages
1315-1319
ISSN
0003-1488 (ISSN-L)
DOI
10.2460/javma.1995.207.10.1315
OpenAlex
W2292561019
Cited by
18
References
0
Citations by year
2019: 1 · 2018: 1 · 2014: 1 · 2013: 1 · 2012: 3
FWCI
0.00
Type
journal article
Language
en
Open access
Locations
  • Journal of the American Veterinary Medical Association (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
  • Health Sciences › Medicine › Pharmacology (medical) › Drug-Induced Adverse Reactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords
erythema multiforme major, disseminated intravascular coagulation, D-limonene, dogs, insecticide toxicity, epidermal necrosis, hemorrhage, thrombocytopenia, leukocytosis, anemia, fibrin degradation products, hepatotoxicity
MeSH terms
Limonene, Animals, Blood Cell Count, Blood Chemical Analysis, Diagnosis, Differential, Disseminated Intravascular Coagulation, Dog Diseases, Dogs, Erythema Multiforme, Female, Insecticides, Plants, Skin, Terpenes, Cyclohexenes

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CoChat. (2026). Citation check: Erythema multiforme major and disseminated intravascular coagulation in a dog following application of a d-limonene-based insecticidal dip. https://app.cochat.ai/papers/10.2460/javma.1995.207.10.1315
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Rosenbaum, M. R., & Kerlin, R. L. (1995). Erythema multiforme major and disseminated intravascular coagulation in a dog following application of a d-limonene-based insecticidal dip. Journal of the American Veterinary Medical Association. https://doi.org/10.2460/javma.1995.207.10.1315

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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