Estimates of alcohol-related oesophageal cancer burden in Japan: systematic review and meta-analyses
Open accessAbstract
OBJECTIVE: To refine estimates of the burden of alcohol-related oesophageal cancer in Japan. METHODS: We searched PubMed for published reviews and original studies on alcohol intake, aldehyde dehydrogenase polymorphisms, and risk for oesophageal cancer in Japan, published before 2014. We conducted random-effects meta-analyses, including subgroup analyses by aldehyde dehydrogenase variants. We estimated deaths and loss of disability-adjusted life years (DALYs) from oesophageal cancer using exposure distributions for alcohol based on age, sex and relative risks per unit of exposure. FINDINGS: We identified 14 relevant studies. Three cohort studies and four case-control studies had dose-response data. Evidence from cohort studies showed that people who consumed the equivalent of 100 g/day of pure alcohol had an 11.71 fold, (95% confidence interval, CI: 2.67-51.32) risk of oesophageal cancer compared to those who never consumed alcohol. Evidence from case-control studies showed that the increase in risk was 33.11 fold (95% CI: 8.15-134.43) in the population at large. The difference by study design is explained by the 159 fold (95% CI: 27.2-938.2) risk among those with an inactive aldehyde dehydrogenase enzyme variant. Applying these dose-response estimates to the national profile of alcohol intake yielded 5279 oesophageal cancer deaths and 102,988 DALYs lost - almost double the estimates produced by the most recent global burden of disease exercise. CONCLUSION: Use of global dose-response data results in an underestimate of the burden of disease from oesophageal cancer in Japan. Where possible, national burden of disease studies should use results from the population concerned.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Genetic variations in the aldehyde dehydrogenase 2 gene affect the risk relationship between alcohol consumption and oral cavity and oesophageal cancer.
“Specifically, genetic variations in the aldehyde dehydrogenase 2 gene have been shown to affect the risk relationship between alcohol consumption and oral cavity and oesophageal cancer 175, 181, 183.”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [175]
Some differences in risk relations between alcohol use and disease/mortality outcomes are expected in different regions.
“Given the genetic and environmental differences, we would expect some differences in risk relations between alcohol use and disease/mortality outcomes in different regions”
From The relationship between different dimensions of alcohol use and the burden of disease—an update (2017) · cites this paper as [175]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
The citation lists haven’t been fetched yet
References 59 · Cited by 44
Research works printed but not linked: 1
- [8]Stewart BW, Wild CP, editors. World cancer report 2014. Lyon: International Agency for Research on Cancer; 2014. 39432694
- Authors
- Roerecke, M., Shield, K. D., Higuchi, S., Yoshimura, A., Larsen, E., Rehm, M. X., & Rehm, J.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Kurihama Medical and Addiction Center (JP)
- Toronto Metropolitan University (CA)
- Corresponding author
- Roerecke, Michael
- Venue
- Bulletin of the World Health Organization
- Publisher
- WHO Press
- Published
- 2015-02-24
- Volume
- 93
- Issue
- 5
- Pages
- 329-338C
- ISSN
- 0042-9686 (ISSN-L)
- PMC
- PMC4431512
- OpenAlex
- W2070630775
- Cited by
- 44
- References
- 59
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 5 · 2016: 5 · 2015: 3
- FWCI
- 1.21
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- cc-by
- Locations
- Bulletin of the World Health Organization (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Esophageal Cancer Research and Treatment
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Keywords
- esophageal cancer, alcohol consumption, dose-response relationship, disability-adjusted life years, Japan
- MeSH terms
- Alcohol Dehydrogenase, Alcohol Drinking, Ethanol, Esophageal Neoplasms, Humans, Japan, Risk Factors, Quality-Adjusted Life Years
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
