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Relationship between sex hormones levels and 18 F-FDG uptake by the ovaries in premenopausal woman
Open accessAbstract
Background: The study was conducted to evaluate the effect of sex hormones on F-18 fluorodeoxyglucose ( 18 F-FDG) uptake by normal ovaries. Patients and methods: A total of 197 premenopausal women were included in this study. Based on 18 F-FDG positron emission tomography/computed tomography (PET/CT) images obtained from these subjects, the association of ovarian 18 F-FDG uptake with levels of sex hormones, including estradiol, progesterone, testosterone, follicle-stimulating hormone, and luteinizing hormone was investigated. We also analysed the relationship between the menstrual cycle and ovarian 18 F-FDG uptake. Results: The highest ovarian 18 F-FDG uptake occurred at 2 weeks after the onset of menstruation (median maximum standardized uptake value [SUVmax] = 3.40, median mean SUV [SUVmean] = 2.20), and the lowest ovarian 18 F-FDG uptake was observed during the first week of the menstrual cycle (median SUVmax = 1.60, median SUVmean = 1.20). Ovarian 18 F-FDG uptake was weakly positively correlated with progesterone levels ( rho = 0.28, p < 0.001 for SUVmax, rho = 0.30, p < 0.001 for SUVmean), and this pattern was consistently observed in subjects in the follicular-phase group ( rho = 0.29, p = 0.003 for both SUVmax and SUVmean) but not in subjects in the luteal-phase group. Conclusions: Based on PET images, ovarian glucose metabolism in premenopausal women tended to increase slightly with increasing progesterone concentration.
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In women, [18F]FDG uptake in ovaries and breast tissue varies with progesterone levels and age.
“In women, [18F]FDG uptake in the ovaries and breast tissue varies with progesterone levels and age [11,12].”
From Influences on PET Quantification and Interpretation (2022) · cites this paper as [12]
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References 19 · Cited by 8
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Metadata
- Authors
- Kim, T. H., Kim, M. R., Jung, Y., & An, Y.-S.
- Affiliations
- Ajou University (KR)
- Department of Obstetrics and Gynecology, Ajou University School of Medicine , Suwon , South Korea
- Department of Surgery, Ajou University School of Medicine , Suwon , South Korea
- Corresponding author
- An, Young-Sil
- Venue
- Radiology and Oncology
- Publisher
- Walter de Gruyter GmbH
- Published
- 2019-09-01
- Volume
- 53
- Issue
- 3
- Pages
- 293-299
- ISSN
- 1318-2099 (ISSN-L)
- 1581-3207
- PMC
- PMC6765169
- OpenAlex
- W2976278666
- Cited by
- 8
- References
- 19
- Citations by year
- 2025: 3 · 2023: 1 · 2022: 2 · 2021: 2
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Radiology and Oncology (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- AJOU Open Repository (Ajou University) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Oncology › Ovarian cancer diagnosis and treatment
- Keywords
- FDG uptake, sex hormones, progesterone, estradiol, testosterone, follicle-stimulating hormone, luteinizing hormone, menstrual cycle, follicular phase, luteal phase, premenopausal women
- MeSH terms
- Positron Emission Tomography Computed Tomography, Adult, Estradiol, Female, Follicle Stimulating Hormone, Glucose, Humans, Luteinizing Hormone, Menstrual Cycle, Middle Aged, Ovary, Progesterone, Retrospective Studies, Testosterone, Time Factors, Premenopause, Statistics, Nonparametric, Radiopharmaceuticals, Fluorodeoxyglucose F18, Gonadal Hormones
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