Cited by 258Chemokine receptors and signalingMast cells and histamineAsthma and respiratory diseases

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MCP-1 and RANTES Are Mediators of Acute and Chronic Inflammation

Conti, P., DiGioacchino, M.·2001·Allergy and Asthma Proceedings

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Abstract

Regulation of leukocyte migration and activation by chemokines are recognized as potentially important functions in the induction of acute and chronic inflammatory reactions. Regulated upon activation normal T cell expressed and presumably secreted (RANTES), monocyte chemotactic protein-1 (MCP-1), and related molecules constitute the C-C class of the beta chemokine supergene family with inflammatory properties. Here we report that in experimental studies RANTES and MCP-1 provoke mast cell activation and increase histidine decarboxylase mRNA expression in a dose-dependent manner. Moreover, injections of RANTES and MCP-1 in the rat skin cause mast cell, eosinophil, and macrophage recruitment, and prostaglandin E2 (PGE2) generation. In a chronic inflammatory model MCP-1 was found to mediate the recruitment of mononuclear cells in calcified granulomas. In addition, MCP-1 mediated parasitic infections caused by Trichinella spiralis. In accordance with other studies, RANTES and MCP-1 were found to play an important role in the lung allergic inflammation, lung leukocyte infiltration, bronchial hyperresponsiveness, and the recruitment of eosinophils in the pathogenesis of asthma. Here for the first time we propose a new mechanism of pulmonary airway inflammation where RANTES and MCP-1 are deeply involved. We also studied the apparent role played by RANTES in the pathogenesis of relapsing-remitting multiple sclerosis enhancing the inflammatory response within the nervous system.

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Authors: Conti, P., & DiGioacchino, M.
Affiliations: University of Chieti-Pescara (IT)
ORCID: Conti, P.
Venue: Allergy and Asthma Proceedings
Publisher: Oceanside Publications Inc.
Published: 2001-05-01
Volume: 22
Issue: 3
Pages: 133-137
ISSN: 1088-5412 (ISSN-L)
DOI: 10.2500/108854101778148737
OpenAlex: W1991051577
Cited by: 258
References: 0
Citations by year: 2026: 4 · 2025: 10 · 2024: 8 · 2023: 5 · 2022: 9 · 2021: 18 · 2020: 9 · 2019: 18 · 2018: 9 · 2017: 11 · 2016: 15 · 2015: 13 · 2014: 15 · 2013: 12 · 2012: 13
FWCI: 3.84
Type: journal article
Language: en
Open access: closed
Locations: Allergy and Asthma Proceedings (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
Keywords: MCP-1, RANTES, chemokines, CC chemokines, mast cell activation, histidine decarboxylase, eosinophil recruitment, macrophage recruitment, prostaglandin E2, chronic inflammation, granuloma, Trichinella spiralis, asthma, airway inflammation, airway hyperresponsiveness, multiple sclerosis, leukocyte migration
MeSH terms: Animals, Humans, Inflammation Mediators, Chemokines, Chemokine CCL2, Chemokine CCL5, Rats

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MCP-1 and RANTES Are Mediators of Acute and Chronic Inflammation

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