2011 AND 2012 EARLY CAREERS ACHIEVEMENT AWARDS: Placental programming: How the maternal environment can impact placental function1,2
Abstract
Proper establishment of the placenta is important for fetal survival; however, placental adaptations to inadequate maternal nutrition or other stressors are imperative for fetal growth to be optimal. The effects of maternal nutritional status and activity level on placental vascular function and uteroplacental blood flows are important to understand as improper placental function leads to reduced growth of the fetus. In environments where fetal growth can be compromised, potential therapeutics may augment placental function and delivery of nutrients to improve offspring performance during postnatal life. Factors that could enhance placental function include supplementation of specific nutrients, such as protein, hormone supplements, such as indolamines, and increased activity levels of the dam. To understand the mechanism of how the maternal environment can impact uterine or umbilical blood flows, assessment of placental vascular reactivity has been studied in several large animal models. As we begin to understand how the maternal environment impacts uterine and umbilical blood flows and other uteroplacental hemodynamic parameters, development of management methods and therapeutics for proper fetal growth can be achieved.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Maternal nutrition is a major determinant of placental development and alters the morphological, transport and endocrine characteristics of the placenta with consequences for fetal nutrient supply in a wide range of species including laboratory and farm species as well as human and non-human primates.
“In addition, maternal nutrition is a major determinant of placental development and alters the morphological, transport and endocrine characteristics of the placenta with consequences for the fetal nutrient supply in a wide range of species including laboratory and farm species as well as human and non-human primates (47, 144, 204, 522, 550).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [550]
Similar changes in placental growth and efficiency are seen in murine and ovine placentas in response to maternal undernutrition.
“Similar changes in placental growth and efficiency are seen in murine and ovine placentas in response to maternal undernutrition (198,546,550).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [550]
In some, but not all, studies these changes in placental vascularity are accompanied by decreases in cell proliferation, angiogenesis and uterine and/or umbilical blood flow.
“In some, but not all, studies these changes in placental vascularity are accompanied by decreases in cell proliferation, angiogenesis and uterine and/or umbilical blood flow (166, 550, 557).”
From Placental Origins of Chronic Disease (2016) · cites this paper as [550]
The citation lists haven’t been fetched yet
References 105 · Cited by 40
- Authors
- Vonnahme, K. A., Lemley, C. O., Shukla, P., & O'Rourke, S. T.
- Affiliations
- Mississippi State University (US)
- North Dakota State University (US)
- Department of Pharmaceutical Sciences, North Dakota State University, Fargo 58108
- Corresponding author
- Vonnahme, K. A.
- Venue
- Journal of Animal Science
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-06-01
- Volume
- 91
- Issue
- 6
- Pages
- 2467-2480
- ISSN
- 0021-8812 (ISSN-L)
- 1525-3163
- OpenAlex
- W1992228518
- Cited by
- 40
- References
- 105
- Citations by year
- 2026: 1 · 2025: 2 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 2 · 2019: 3 · 2017: 4 · 2016: 6 · 2015: 3 · 2014: 5 · 2013: 3
- FWCI
- 0.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Animal Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
- Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
- Life Sciences › Agricultural and Biological Sciences › Agronomy and Crop Science › Reproductive Physiology in Livestock
- Keywords
- maternal nutrition, placental vascular function, uteroplacental blood flow, umbilical blood flow, fetal growth, indolamines, protein supplementation, fetal programming, large animal model
- MeSH terms
- Animals, Animal Nutritional Physiological Phenomena, Cattle, Female, Fetus, Hemodynamics, Mammals, Placenta, Pregnancy, Umbilical Cord, Uterus, Sus scrofa, Sheep, Domestic, Maternal Nutritional Physiological Phenomena, Fetal Development
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
