Improvement of Hair Graying during a Treatment of Male Pattern Hair Loss Using 1,927-nm Fractionated Thulium Laser Energy and Polydeoxyribonucleotide Injections
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Improvement of Hair Graying during a Treatment of Male Pattern Hair Loss Using 1,927-nm Fractionated Thulium Laser Energy and Polydeoxyribonucleotide InjectionsHair graying is a common age-related hair change with tremendous social and cosmetic concerns among aged individuals.Many mechanisms contribute to hair graying, such as defective melanocyte stem cell renewal, melanocyte apoptosis, and melanocyte migration defects.Accumulation of oxidative stress has been regarded as a key factor influencing these processes.However, currently, there is no standard treatment for reversing hair graying.Herein, we report our observation of improvement of hair graying in a patient with male pattern hair loss during combined treatment with 1,927-nm fractionated thulium laser energy and intra-perifollicular polydeoxyribonucleotide injections.The patient showed increased numbers of pigmented hair follicles and clinical improvement in hair graying after 12 sessions of combined treatment.Accordingly, we suggest that the combined treatment described in this report may be a promising therapeutic method for treating hair graying.
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Use of PDRN alongside fractionated thulium laser therapy has shown promising results in enhancing both hair density and thickness.
“Similarly, the use of PDRN alongside fractionated thulium laser therapy has shown promising results in enhancing both hair density and thickness [121,122].”
From Comparison of Polynucleotide and Polydeoxyribonucleotide in Dermatology: Molecular Mechanisms and Clinical Perspectives (2025) · cites this paper as [122]
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- Westgate GE, Botchkareva NV, Tobin DJ. The biology of hair diversity. Int J Cosmet Sci 2013;35:329-36.
- Cho SB, Zheng Z, Kang JS, Kim H. Therapeutic efficacy of 1,927- nm fractionated thulium laser energy and polydeoxyribonucleo- tide on pattern hair loss. Med Lasers 2016;5:22-8.
- Kang JS, Zheng Z, Choi MJ, Lee SH, Kim DY, Cho SB. The ef- fect of CD34+ cell-containing autologous platelet-rich plasma injection on pattern hair loss: a preliminary study. J Eur Acad Dermatol Venereol 2014;28:72-9.
- Keogh EV, Walsh RJ. Rate of greying of human hair. Nature 1965;207:877-8.
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- Bitto A, Polito F, Altavilla D, Minutoli L, Migliorato A, Squadrito F. Polydeoxyribonucleotide (PDRN) restores blood flow in an ex- perimental model of peripheral artery occlusive disease. J Vasc Surg 2008;48:1292-300.
- Kovacs D, Raffa S, Flori E, Aspite N, Briganti S, Cardinali G, et al. Keratinocyte growth factor down-regulates intracellular ROS production induced by UVB. J Dermatol Sci 2009;54:106- 13.
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Kim, S. T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17081024 · Cited by 18 · see citing works
- Authors
- Choi, Y. J., Cho, S., Kim, Y. K., & Kim, D. S.
- Affiliations
- Yonsei BB Skin Clinic, Seoul, Korea
- Yonsei Star Skin & Laser Clinic, Seoul, Korea
- Yonsei Young Skin Clinic, Seoul, Korea
- Corresponding author
- Kim, Dae Suk
- Venue
- Medical Lasers
- Published
- 2017-06-30
- Volume
- 6
- Issue
- 1
- Pages
- 37-40
- ISSN
- 2287-8300 (ISSN-L)
- 2288-0224
- OpenAlex
- W2738593551
- Cited by
- 11
- References
- 0
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2022: 1 · 2021: 1 · 2019: 1
- FWCI
- 0.38
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Medical Lasers (publishedVersion, cc-by-nc)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Health Sciences › Medicine › Dermatology › Dermatologic Treatments and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Keywords
- hair graying, androgenetic alopecia, hair follicle pigmentation, oxidative stress, melanocyte stem cells, melanocyte apoptosis
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