Definition of Treatment-Resistant Depression in the Medicare Population
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Higher indirect costs are reported in TRD as a consequence of relatively greater impairment in psychosocial function, greater need for disability benefits, higher workplace disability and absenteeism, as well as negative impact on carers.
“Higher indirect costs are also reported in TRD as a consequence of rel atively greater impairment in psychoso cial function, greater need for disability benefits, higher workplace disability and absentee ism, as well as the negative impact on carers 10, 21,24- 35 .”
From Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions (2023) · cites this paper as [30]
The depression treatment cascade approach underscores the high prevalence of poor outcomes of depression in primary care, of which a significant percentage would be expected to meet criteria for TRD.
“The foregoing cascade approach - which in tegrates aspects of misdiagnosis, non- ad herence, inadequate treatment trials, as well as implementation gaps - underscores the high prevalence of poor outcomes of depression in primary care, of which a significant percentage would be expected to meet crite ria for TRD 10,30,64,71,107,108 .”
From Treatment‐resistant depression: definition, prevalence, detection, management, and investigational interventions (2023) · cites this paper as [30]
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McIntyre, R. S., Alsuwaidan, M., Baune, B. T., Berk, M., Demyttenaere, K., Goldberg, J. F., Gorwood, P., Ho, R., Kasper, S., Kennedy, S. H., et al. (2023) · World Psychiatry · doi:10.1002/wps.21120 · Cited by 836 · see citing works
Defining treatment‐resistant depression
Gaynes, B. N., Lux, L., Gartlehner, G., Asher, G., Forman‐Hoffman, V., Green, J., Boland, E., Weber, R. P., Randolph, C., Bann, C., et al. (2020) · Depression and Anxiety · doi:10.1002/da.22968 · Cited by 447 · see citing works
Self-citationMcAllister-Williams, R. H., Arango, C., Blier, P., Demyttenaere, K., Falkai, P., Gorwood, P., Hopwood, M., Javed, A., Kasper, S., Malhi, G. S., et al. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.02.023 · Cited by 278 · see citing works
Brown, S., Rittenbach, K., Cheung, S., McKean, G., MacMaster, F. P., & Clement, F. (2019) · The Canadian Journal of Psychiatry · doi:10.1177/0706743719828965 · Cited by 151 · see citing works
Turkoz, I., Alphs, L., Singh, J., Jamieson, C., Daly, E., Shawi, M., Sheehan, J. J., Trivedi, M. H., & Rush, A. J. (2021) · Acta Psychiatrica Scandinavica · doi:10.1111/acps.13260 · Cited by 104 · see citing works
Approval of esketamine for treatment-resistant depression
Singh, J. B., Daly, E. J., Mathews, M., Fedgchin, M., Popova, V., Hough, D., & Drevets, W. C. (2020) · The Lancet Psychiatry · doi:10.1016/s2215-0366(19)30533-4 · Cited by 46 · see citing works
Treatment resistant depression in women with peripartum depression
Cepeda, M. S., Kern, D. M., & Nicholson, S. (2019) · BMC Pregnancy and Childbirth · doi:10.1186/s12884-019-2462-9 · Cited by 31 · see citing works
Castro, M., Wilkinson, S. T., Al Jurdi, R. K., Petrillo, M. P., Zaki, N., Borentain, S., Fu, D. J., Turkoz, I., Sun, L., Brown, B., et al. (2023) · CNS Drugs · doi:10.1007/s40263-023-01026-3 · Cited by 25 · see citing works
Morrens, J., Mathews, M., Popova, V., Borentain, S., Rive, B., Gonzalez Martin Moro, B., Jamieson, C., & Zhang, Q. (2022) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s358367 · Cited by 24 · see citing works
Sackeim, H. A., Dibué, M., Bunker, M. T., & Rush, A. J. (2020) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s286977 · Cited by 15 · see citing works
Jensen, K. J., Gronemann, F. H., Ankarfeldt, M. Z., Jimenez-Solem, E., Alulis, S., Riise, J., Bødker, N., Osler, M., & Petersen, J. (2022) · PLOS ONE · doi:10.1371/journal.pone.0275299 · Cited by 15 · see citing works
Perrone, V., Sangiorgi, D., Andretta, M., Ducci, G., Forti, B., Francesa Morel, P. C., Gambera, M., Maina, G., Mencacci, C., Mennini, F. S., et al. (2021) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s314111 · Cited by 10 · see citing works
- Authors
- Bradley N. Gaynes, M. D., Gary Asher, M. D., Gerald Gartlehner, M. D., Valerie Hoffman, P. D., Josh Green, B. A., Erin Boland, M. S. P. H., Linda Lux, M. P. A., Charlotte Randolph, B. A., Carla Bann, P. D., Emmanuel Cokker-Schwimmer, M. P. H., & M.
- Venue
- Systematic Review Data Repository
- Publisher
- Systematic Review Data Repository
- Published
- 2018
- OpenAlex
- W2976833091
- Cited by
- 58
- References
- 0
- Citations by year
- 2025: 2 · 2024: 8 · 2023: 12 · 2022: 10 · 2021: 11 · 2020: 9 · 2019: 6
- FWCI
- 4.22
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Europe PMC (PubMed Central)
- Brown Digital Repository
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- treatment-resistant depression, Medicare, older adults, depression diagnosis, antidepressant response
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