Isolated teratozoospermia: a cause of male sterility in the era oF ICSI?
Open accessAbstract
Single structural defects involving the totality of ejaculated sperm are among rare cases of untreatable human male infertility. This form of infertility is of genetic origin and is generally transmitted as an autosomal recessive traits. Acrosome agenesis or globozoospermia results from perturbed expression of nuclear proteins or from an altered Golgi-nuclear recognition during spermiogenesis. Failed fertilization after intracytoplasmic sperm injection (ICSI) of acrosomeless sperm is consistent with an inability of sperm to activate oocytes. Acephalic spermatozoa result from a head-neck defect due to a failure of migration of the tail anlagen and related centriole to the caudal pole of spermatids. An abnormal sperm centrosome function may explain the defective embryo cleavage after ICSI with sperm carrying a fragile head-neck junction. Primary cilia dyskinesia (PCD) and dysplasia of the fibrous sheath (DFS) are isolate defects associated with absent or greatly reduced sperm motility due to an abnormal ciliary structure and function (PCD) or to a disorganized fibrous sheath (DFS). Numerous defective genes are potentially involved in human isolated teratozoospermia but such defects have not been defined at the molecular level in most cases. IVF-ICSI is the only available method for obtaining live births with sperm carrying these defects, but the outcome is poor and the genetic risk for the subsequent generation can not be determined.
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A very limited number of review articles specifically address isolated teratozoospermia.
“Despite the huge increase in the literature on male infertility, a very limited number of review articles specifically address isolated teratozoospermia (17,21).”
From Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review (2024) · cites this paper as [21]
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Do morphological anomalies reflect chromosomal aneuploidies?*: Case Report
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Isolated teratozoospermia: revisiting its relevance in male infertility: a narrative review
Atmoko, W., Savira, M., Shah, R., Chung, E., & Agarwal, A. (2024) · Translational Andrology and Urology · doi:10.21037/tau-23-397 · Cited by 23 · see citing works
“Despite the huge increase in the literature on male infertility, a very limited number of review articles specifically address isolated teratozoospermia (17,21).”
- Authors
- Francavilla, S.
- Affiliations
- University of L'Aquila (IT)
- Corresponding author
- Francavilla, Sandro
- ORCID
- Francavilla, Sandro
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2007
- Volume
- 12
- Issue
- 1
- Pages
- 69
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/2049
- OpenAlex
- W2094671280
- Cited by
- 25
- References
- 2
- Citations by year
- 2026: 3 · 2024: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 2 · 2012: 4
- FWCI
- 0.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università degli Studi dell Aquila (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- male infertility, intracytoplasmic sperm injection, globozoospermia, primary ciliary dyskinesia, autosomal recessive inheritance, spermiogenesis, oocyte activation, embryo cleavage, genetic risk
- MeSH terms
- Acrosome, Animals, Disease Models, Animal, Humans, Infertility, Male, Male, Sperm Head, Sperm Tail, Spermatozoa, Sperm Injections, Intracytoplasmic, Asthenozoospermia
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