Approaches to improve photodynamic therapy of cancer
Open accessAbstract
Photodynamic therapy (PDT) is a clinically approved method of tumor treatment. Its unique mechanism of action results from minimal invasiveness and high selectivity towards transformed cells. However, visible light used to excite most photosensitizers has rather limited ability to penetrate tissues resulting in insufficient destruction of deeply seated malignant cells. Therefore, novel strategies for further potentiation of the anticancer effectiveness of PDT have been developed. These include combined treatments with surgery, chemo- and radiotherapy, strategies targeting cytoprotective mechanisms induced in PDT-treated cells, as well as attempts aimed at enhancement of PDT-mediated antitumor immune response. Moreover, new photosensitizers and novel light sources are being developed. Impressive progress in nanotechnology and understanding of tumor cell biology rise hopes for further improvements in this elegant and promising method of cancer treatment.
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Apart from direct cellular cytotoxicity, vascular shutdown and local inflammatory reaction contribute to the overall PDT effect.
“It is generally agreed that apart from the direct cellular cytotoxicity, two other important factors contribute to the overall PDT effect: the vascular shutdown and local inflammatory reaction [1,2,3,4].”
From Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer (2011) · cites this paper as [3]
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References 163 · Cited by 55
- Authors
- Firczuk, M.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2011
- Volume
- 16
- Issue
- 1
- Pages
- 208
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/3684
- OpenAlex
- W2049180549
- Cited by
- 55
- References
- 163
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 5 · 2020: 2 · 2019: 4 · 2018: 6 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 4 · 2013: 9 · 2012: 4
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundacja na rzecz Nauki Polskiej
- European Regional Development Fund
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
- Health Sciences › Medicine › Epidemiology › Nonmelanoma Skin Cancer Studies
- Keywords
- photodynamic therapy, photosensitizers, light penetration, combination therapy, antitumor immunity, nanotechnology, cancer cell biology, cancer therapy
- MeSH terms
- Ambulatory Care, Animals, Antineoplastic Agents, Combined Modality Therapy, Humans, Neoplasms, Photochemotherapy, Skin Neoplasms, Photosensitizing Agents, Reactive Oxygen Species, Oxidative Stress, Nanotechnology, Adaptive Immunity
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