Mechanisms and emerging functions of DNA degradation in the epidermis
Open accessAbstract
Degradation of DNA is involved in key processes maintaining the integrity of the epidermis such as the cornification of keratinocytes, the removal of damaged cells and the defense against potentially harmful microorganisms. Recent studies have characterized some of the molecular mechanisms and physiological functions of DNA degradation in the epidermis. Deoxyribonuclease (DNase)1L2 and TREX2 were identified as epidermis-specific DNases and DNase 2 was shown to be the predominant DNA-degrading enzyme on the surface of the skin. Here we review the latest insights into the DNA catabolism in the skin and discuss open questions pertaining to the molecular biology of epidermal DNA breakdown.
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The number of thymic epithelial cells declines over time and they are not replaced because of impaired proliferation.
“It is clear that the number of thymic epithelial cells declines over time and that they are not replaced, as a result of impaired proliferation (38).”
From Causes, consequences, and reversal of immune system aging (2013) · cites this paper as [38]
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References 102 · Cited by 39
- Authors
- Eckhart, L.
- Affiliations
- Medical University of Vienna (AT)
- Corresponding author
- Eckhart, Leopold
- ORCID
- Eckhart, Leopold
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2012
- Volume
- 17
- Issue
- 7
- Pages
- 2461
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/4065
- OpenAlex
- W2038712512
- Cited by
- 39
- References
- 102
- Citations by year
- 2026: 3 · 2024: 1 · 2023: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 5 · 2016: 6 · 2015: 2 · 2014: 4 · 2013: 5 · 2012: 5
- FWCI
- 0.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Cooperation in Science and Technology
- Austrian Science Fund (P21312, P 20043)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- DNA degradation, epidermis, keratinocytes, keratinization, TREX2, DNase, skin surface, epidermal barrier integrity, antimicrobial defense
- MeSH terms
- Epidermal Cells, Animals, Antibodies, Antinuclear, Communicable Diseases, Deoxyribonucleases, DNA, Epidermis, Humans, Immunity, Innate, Keratinocytes, Biofilms, DNA Degradation, Necrotic, DNA Fragmentation, Host-Pathogen Interactions
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