Skin barrier in atopic dermatitis
Open accessAbstract
The skin represents the largest organ of the body and provides a vital interface between the body and the environment. Hereditary and acquired alterations of structural proteins and lipids of the stratum corneum and epidermal tight junctions leading to a diminished skin barrier function are major causative factors for a number of skin diseases, in particular atopic dermatitis (AD). This review summarizes current knowledge on the role of the skin barrier in AD with regard to pathogenesis and treatment, on the relationship between skin barrier abnormalities and immune aberrations, and on potential therapies aimed at repair of the skin barrier. Furthermore recent advances in the genetics of AD will be addressed.
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References 118 · Cited by 115
Research works printed but not linked: 2
- [7]7. N. Morar, P. Edster, T. Street, S. Weidinger, W.L. Di, A. Dixon, M. Taylor, R. Holt, J. Broxholme, N. Kloop, N. Novak, A. Bockelbrinck, J. Ragoussis, T. Illig, J. Harper,W. Cookson, M. Moffatt: Fine mapping of susceptibility genes for atopic dermatitis in the epidermal differentiation complex on chromosome 1q21. Br J Dermatol 157, 3 (2007)
- [26]26. D.Y.M. Leung, P.S. Gao, D.N. Grigoryev, N.M. Rafaels, J.E. Streib, M.D. Howell, P.A. Taylor, M. Boguniewicz, J. Canniff, B. Armstrong, D.J. Zaccaro, L.C. Schneider, T.R. Hata, J.M. Hanifin, L.A. Beck, A. Weinberg, K.C. Barnes: Human atopic dermatitis complicated by eczema herpeticum is associated with abnormalities in IFN-gamma response. J Allergy Clin Immunol 127(4), 965-U210 (2011)
- Authors
- Kezic, S.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2014
- Volume
- 19
- Issue
- 3
- Pages
- 542
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/4225
- OpenAlex
- W2316497382
- Semantic Scholar
- 719a65b5944a33069497b697706e3555cdefcabd
- Cited by
- 115
- References
- 118
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 4 · 2022: 3 · 2021: 6 · 2020: 10 · 2019: 11 · 2018: 14 · 2017: 10 · 2016: 8 · 2015: 24 · 2014: 11 · 2013: 1 · 2012: 1
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Dermatology › Contact Dermatitis and Allergies
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advancements in Transdermal Drug Delivery
- Keywords
- atopic dermatitis, skin barrier, stratum corneum, skin barrier lipids, skin barrier proteins, skin barrier repair, pathogenesis, treatment
- MeSH terms
- Filaggrin Proteins, Dermatitis, Atopic, Humans, Intermediate Filament Proteins, Lipids, Skin Absorption, Tight Junctions
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