Emergence of life: from functional RNA selection to natural selection and beyond
Abstract
This study tracks the rise, evolution and post-evolution of the genetic information system through emergence of life. The major stages traversed include prebiotic synthesis, functional RNA selection by metabolite, RNA World, peptidated RNA world, co-evolution of genetic code and amino acid biosynthesis, last universal common ancestor, Darwinian evolution and synthetic life.
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There are two types of amino acids, depending on whether they were supplied by the prebiotic environment (Phase 1) or were biosynthetically produced (Phase 2).
“There are two types of amino acids, depending on whether they were supplied by the prebiotic environment (Phase 1) or were biosynthetically produced (Phase 2) [68,105].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [105]
The first phase of amino acids consists of glycine, alanine, serine, aspartic acid, glutamic acid, valine, leucine, isoleucine, proline, and threonine.
“The first phase of amino acids consists of glycine, alanine, serine, aspartic acid, glutamic acid, valine, leucine, isoleucine, proline, and threonine.”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [105]
Phase 2 amino acids include phenylalanine, tyrosine, arginine, histidine, tryptophan, asparagine, glutamine, lysine, cysteine, and methionine.
“Phase 2 amino acids include phenylalanine, tyrosine, arginine, histidine, tryptophan, asparagine, glutamine, lysine, cysteine, and methionine.”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [105]
Phase 2 amino acids entered the code by means of biosynthesis from the Phase 1 amino acids with the emergence of tRNA molecules, aminoacyl transferase enzyme, and ribosomes.
“Phase 2, the amino acids entered the code by means of biosynthesis from the Phase 1 amino acids with the emergence of tRNA molecules, aminoacyl transferase enzyme, and ribosomes [68,82,105,108].”
From The Origin of Prebiotic Information System in the Peptide/RNA World: A Simulation Model of the Evolution of Translation and the Genetic Code (2019) · cites this paper as [105]
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References 100 · Cited by 18
- Authors
- Tze-Fei Wong, J.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2014
- Volume
- 19
- Issue
- 7
- Pages
- 1117
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/4271
- OpenAlex
- W2333219142
- Cited by
- 18
- References
- 100
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 3
- FWCI
- 1.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Physics and Astronomy › Astronomy and Astrophysics › Origins and Evolution of Life
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Keywords
- origin of life, prebiotic synthesis, RNA world, genetic code evolution, amino acid biosynthesis, last universal common ancestor, Darwinian evolution, synthetic life
- MeSH terms
- Origin of Life, Animals, Biological Evolution, Genetic Code, Humans, Phylogeny, RNA, RNA, Transfer, Selection, Genetic, Evolution, Molecular
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