The role of mitochondrial fusion and fission in skeletal muscle function and dysfunction
Open accessAbstract
Classic textbook depictions of mitochondria portray these organelles to be static bean-shaped structures. However the mitochondrial population is quite heterogeneous, and can form small individual organelles or extended reticula throughout muscle. This morphological plasticity is controlled by fission and opposing fusion events. Skeletal muscle mitochondrial morphology has been demonstrated to be altered under various disease conditions, including diabetes, denervation, as well as during development, aging, and exercise. This implies that mitochondrial fission and fusion machinery components are involved in regulating the architecture of the organelle during various states of muscle use and disuse. Furthermore, disruptions in either of these opposing processes have been demonstrated to result in diseases, suggesting that proper maintenance of mitochondrial morphology is critical for proper cell function.
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Electron microscopy and biochemical analyses show small, more fragmented mitochondria in muscles from old compared with young adult hosts.
“electron microscopy and biochemical analyses have shown small, more fragmented mitochondria in muscles from old as compared to young adult hosts (56, 57)”
From Mitochondria initiate and regulate sarcopenia (2017) · cites this paper as [56]
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References 31 · Cited by 50
- Authors
- Hood, D. A.
- Affiliations
- York University (CA)
- Corresponding author
- Hood, David A.
- ORCID
- Hood, David A.
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2015
- Volume
- 20
- Issue
- 1
- Pages
- 157-172
- ISSN
- 1093-4715 (ISSN-L)
- 1093-9946
- DOI
- 10.2741/4303
- OpenAlex
- W2326966452
- Cited by
- 50
- References
- 31
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 7 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 5 · 2015: 4
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in bioscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- mitochondrial fusion, mitochondrial fission, skeletal muscle, mitochondrial morphology, mitochondrial dynamics, mitochondrial reticulum, diabetes mellitus, denervation, muscle aging, physical activity, mitochondrial disease, muscle disuse
- MeSH terms
- Animals, Humans, Mitochondria, Muscle, Muscle, Skeletal
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