Cancer stem cell and niche
Open accessAbstract
Recent research on cancer has generated a new model for cancer growth-cancer stem cell model. This model can explain the inefficiency of conventional therapy. Tumor tissue, like normal tissue, is continuously repopulated from pools of self-renewing stem cells growing in a "niche", which is made up of a specialized vascular bed of endothelial cells, associated cells of mesenchymal origin and extracellular matrix components. In this review, we will introduce the models of cancer development, the roles of stem cells in tumor progression, the components of niche which affects the cell fate of cancer stem cells (CSCs), their different regulatory factors, as well as the clinical implication of CSCs in cancer treatment.
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Cancer cells can show fluctuating levels of stem-like activity.
“Cancer cells can display fluctuating levels of stem-like activities [151].”
From Mesenchymal stem cell secretome and regenerative therapy after cancer (2013) · cites this paper as [151]
The sections on CSCs and their niche and on cellular signaling pathways say that environmental signals regulate stem-cell functions and the balance between self-renewal and differentiation. This supports the possibility that stem-like activity can change, but our copy does not say that individual cancer cells display fluctuating levels of that activity over time. No page numbers were available in the indexed passages. (LLM, conf=0.74)
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References 66 · Cited by 19
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- [79]79. Tirino, V., V. Desiderio, R. d'Aquino, F. De Francesco, G. Pirozzi, U. Galderisi, C. Cavaliere, A. De Rosa & G. Papaccio: Detection and characterization of CD133+ cancer stem cells in human solid tumours. PLoS ONE, 3, e3469 (2008)
- [81]81. Collins, A. T., P. A. Berry, C. Hyde, M. J. Stower & N. J. Maitland: Prospective identification of tumorigenic prostate cancer stem cells. Cancer Res, 65, 10946-51 (2005) Abbreviation: CSC: cancer stem cell; AML: acute myeloid leukemia; SCID: severe combined immune- deficient; pCSCs: precancerous stem cell; VEGF: Vascular endothelial growth factor; SCLGC: stem cell-like glioma cells; GSC: germ-line stem cells; BM: basement membrane; ECM: extracellular matix; CAF: cancer- associated fibroblasts; MMPs: matrix metalloproteinases; TAM: tumor-associated macrophages; HIF: hypoxia- induced transcription factors. HGF: hepatocyte growth factor; IL-8: interleukin 8; LRP: lipoprotein receptor- related protein; GSK3beta: glycogen synthase kinase-3beta; CK1: casein kinase 1; APC: adenomatous polyposis coli; HSCs: hematopoietic stem cells; CML: chronic myeloid leukemia; NECD: notch extracellular domain; NICD: notch intracellular domain; Mam: Mastermind; CNS: central nervous system; T-ALL: T-cell acute lymphoblastic leukemias; SMO: smoothened protein; BMP: bone morphogenic protein; GBM: glioblastoma Key Words: Cancer Stem Cell, Niche, Pathway, Tumor Metastasis, Tumor Angiogenesis, Review Send correspondence to: Daotai Nie, Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine, PO Box 19626, Springfield, IL 62794-9626, USA, Tel: 217-545- 9702, Fax: 217-545-3227, E-mail: dnie@siumed.edu http://www.bioscience.org/current/volS2.htm
- Authors
- Nie, D.
- Affiliations
- SIU Medicine (US)
- Corresponding author
- Nie, Daotai
- ORCID
- Nie, Daotai
- Venue
- Frontiers in Bioscience
- Publisher
- IMR Press
- Published
- 2010
- Volume
- S2
- Issue
- 1
- Pages
- 184-193
- ISSN
- 1944-7906 (ISSN-L)
- 1945-0516
- 1945-0524
- DOI
- 10.2741/s56
- OpenAlex
- W2003263637
- Cited by
- 19
- References
- 66
- Citations by year
- 2022: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 1 · 2016: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 0.18
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Frontiers in Bioscience-Scholar (publishedVersion)
- PubMed (publishedVersion)
- Funders
- China Scholarship Council
- National Cancer Institute (R15CA133776, R01CA131445)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Keywords
- cancer stem cells, tumor microenvironment, cancer stem cell niche, tumor repopulation, self-renewal, tumor progression, cell fate regulation, extracellular matrix, mesenchymal cells, endothelial cells, cancer therapy resistance
- MeSH terms
- Humans, Models, Biological, Neoplasm Metastasis, Neoplasms, Neovascularization, Pathologic, Neoplastic Stem Cells, Signal Transduction, Drug Delivery Systems, Wnt Proteins, Receptors, Notch, Hedgehog Proteins
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