Impact of age, ethnicity, sex and prior infection status on immunogenicity following a single dose of the BNT162b2 mRNA COVID-19 vaccine: real-world evidence from healthcare workers, Israel, December 2020 to January 2021
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Abstract
The BNT162b2 mRNA COVID-19 vaccine showed high efficacy in clinical trials but observational data from populations not included in trials are needed. We describe immunogenicity 21 days post-dose 1 among 514 Israeli healthcare workers by age, ethnicity, sex and prior COVID-19 infection. Immunogenicity was similar by ethnicity and sex but decreased with age. Those with prior infection had antibody titres one magnitude order higher than naïve individuals regardless of the presence of detectable IgG antibodies pre-vaccination.
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The addition of memory B cells in this analysis, both in terms of frequency and phenotype, provides complementary data that strengthens current serology-based evidence for a single-dose vaccine schedule in COVID-19 recovered individuals.
“The addition of memory B cells in this analysis, both in terms of frequency and phenotype, provides complemenary data that strengthens current serology-based evidence (20, 21, 23, 24, 28, 29) for a single-dose vaccine schedule in COVID-19 recovered individuals.”
From Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination (2021) · cites this paper as [29]
Vaccine coverage of 79%, 90%, and 65% was reported in three recent single-centre studies of health-care workers in Israel and the UK.
“three recent single-centre studies in health-care workers in Israel and the UK reported vaccine coverage of 79%, 90%, and 65%, respectively.”
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Cites
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- Authors
- Abu Jabal, K., Ben-Amram, H., Beiruti, K., Batheesh, Y., Sussan, C., Zarka, S., & Edelstein, M.
- Affiliations
- Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel
- Rebecca Sieff Hospital (IL)
- Ziv Medical Centre, Safed, Israel
- Bar-Ilan University (IL)
- Corresponding author
- Edelstein, Michael
- Venue
- Eurosurveillance
- Published
- 2021-02-11
- Volume
- 26
- Issue
- 6
- ISSN
- 1025-496X (ISSN-L)
- 1560-7917
- PMC
- PMC7879501
- OpenAlex
- W3127600917
- Cited by
- 271
- References
- 8
- Citations by year
- 2026: 1 · 2025: 12 · 2024: 13 · 2023: 30 · 2022: 103 · 2021: 112
- FWCI
- 20.43
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eurosurveillance (publishedVersion, cc-by)
- medRxiv (acceptedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Social Sciences › Health › Vaccine Coverage and Hesitancy
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- BNT162b2 mRNA vaccine, COVID-19 vaccine immunogenicity, SARS-CoV-2, healthcare workers, age differences, ethnicity, sex differences, prior COVID-19 infection, antibody titers, IgG, real-world evidence
- MeSH terms
- Immunogenicity, Vaccine, COVID-19, COVID-19 Vaccines, mRNA Vaccines, BNT162 Vaccine, Adult, Age Factors, Aged, Dose-Response Relationship, Immunologic, Ethnicity, Female, Health Personnel, Humans, Israel, Male, Middle Aged, Sex Factors, Vaccines, Synthetic
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