Cited by 78SARS-CoV-2 and COVID-19 ResearchCOVID-19 epidemiological studiesCOVID-19 Clinical Research Studies

Molecular epidemiology of the SARS-CoV-2 variant Omicron BA.2 sub-lineage in Denmark, 29 November 2021 to 2 January 2022

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Fonager, Jannik, Bennedbæk, Marc, Bager, Peter, Wohlfahrt, Jan, Ellegaard, Kirsten Maren, Ingham, Anna Cäcilia, Edslev, Sofie Marie, Stegger, Marc +27 more·2022·Eurosurveillance

Abstract

Following emergence of the SARS-CoV-2 variant Omicron in November 2021, the dominant BA.1 sub-lineage was replaced by the BA.2 sub-lineage in Denmark. We analysed the first 2,623 BA.2 cases from 29 November 2021 to 2 January 2022. No epidemiological or clinical differences were found between individuals infected with BA.1 versus BA.2. Phylogenetic analyses showed a geographic east-to-west transmission of BA.2 from the Capital Region with clusters expanding after the Christmas holidays. Mutational analysis shows distinct differences between BA.1 and BA.2.

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  • In some countries, BA.2 was responsible for a greater share of cases, hospitalizations and deaths during the Omicron wave.

    “in some countries, BA.2 was responsible for a greater share of cases, hospitalizations and deaths during the Omicron wave2–4.”

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References 24 · Cited by 78

Authors
Fonager, J., Bennedbæk, M., Bager, P., Wohlfahrt, J., Ellegaard, K. M., Ingham, A. C., Edslev, S. M., Stegger, M., Sieber, R. N., Lassauniere, R., Fomsgaard, A., Lillebaek, T., Svarrer, C. W., Møller, F. T., Møller, C. H., Legarth, R., Sydenham, T. V., Steinke, K., Paulsen, S. J., Castruita, J. A. S., Schneider, U. V., Schouw, C. H., Nielsen, X. C., Overvad, M., Nielsen, R. T., Marvig, R. L., Pedersen, M. S., Nielsen, L., Nilsson, L. L., Bybjerg-Grauholm, J., Tarpgaard, I. H., Ebsen, T. S., Lam, J. U. H., Gunalan, V., & Rasmussen, M.
Affiliations
  • Statens Serum Institut (DK)
  • Virus Research and Development Laboratory, Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark
  • Odense University Hospital (DK)
  • Amager Hospital (DK)
  • Zealand University Hospital Køge (DK)
  • Copenhagen University Hospital (DK)
  • Herlev Hospital (DK)
  • Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
  • Aarhus University Hospital (DK)
Corresponding author
  • Fonager, Jannik
  • Gunalan, Vithiagaran
  • Rasmussen, Morten
Venue
Eurosurveillance
Published
2022-03-10
Volume
27
Issue
10
ISSN
  • 1025-496X (ISSN-L)
  • 1560-7917
OpenAlex
W4220665561
Cited by
78
References
24
Citations by year
2025: 1 · 2024: 12 · 2023: 18 · 2022: 46 · 2021: 1
FWCI
9.41
Type
journal article
Language
en
Open access
Locations
  • Eurosurveillance (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
  • University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by)
Funders
Statens Serum Institut
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
  • Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Keywords
SARS-CoV-2, Omicron variant, molecular epidemiology, phylogenetic analysis, viral mutations, Denmark, capital region
MeSH terms
COVID-19, SARS-CoV-2, Denmark, Humans, Phylogeny, Molecular Epidemiology

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