Molecular epidemiology of the SARS-CoV-2 variant Omicron BA.2 sub-lineage in Denmark, 29 November 2021 to 2 January 2022
Open accessAbstract
Following emergence of the SARS-CoV-2 variant Omicron in November 2021, the dominant BA.1 sub-lineage was replaced by the BA.2 sub-lineage in Denmark. We analysed the first 2,623 BA.2 cases from 29 November 2021 to 2 January 2022. No epidemiological or clinical differences were found between individuals infected with BA.1 versus BA.2. Phylogenetic analyses showed a geographic east-to-west transmission of BA.2 from the Capital Region with clusters expanding after the Christmas holidays. Mutational analysis shows distinct differences between BA.1 and BA.2.
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In some countries, BA.2 was responsible for a greater share of cases, hospitalizations and deaths during the Omicron wave.
“in some countries, BA.2 was responsible for a greater share of cases, hospitalizations and deaths during the Omicron wave2–4.”
From Emergence of SARS-CoV-2 Omicron lineages BA.4 and BA.5 in South Africa (2022) · cites this paper as [3]
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References 24 · Cited by 78
- Authors
- Fonager, J., Bennedbæk, M., Bager, P., Wohlfahrt, J., Ellegaard, K. M., Ingham, A. C., Edslev, S. M., Stegger, M., Sieber, R. N., Lassauniere, R., Fomsgaard, A., Lillebaek, T., Svarrer, C. W., Møller, F. T., Møller, C. H., Legarth, R., Sydenham, T. V., Steinke, K., Paulsen, S. J., Castruita, J. A. S., Schneider, U. V., Schouw, C. H., Nielsen, X. C., Overvad, M., Nielsen, R. T., Marvig, R. L., Pedersen, M. S., Nielsen, L., Nilsson, L. L., Bybjerg-Grauholm, J., Tarpgaard, I. H., Ebsen, T. S., Lam, J. U. H., Gunalan, V., & Rasmussen, M.
- Affiliations
- Statens Serum Institut (DK)
- Virus Research and Development Laboratory, Virus and Microbiological Special Diagnostics, Statens Serum Institut, Copenhagen, Denmark
- Odense University Hospital (DK)
- Amager Hospital (DK)
- Zealand University Hospital Køge (DK)
- Copenhagen University Hospital (DK)
- Herlev Hospital (DK)
- Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark
- Aarhus University Hospital (DK)
- Corresponding author
- Fonager, Jannik
- Gunalan, Vithiagaran
- Rasmussen, Morten
- ORCID
- Fonager, Jannik
- Bennedbæk, Marc
- Bager, Peter
- Wohlfahrt, Jan
- Ingham, Anna Cäcilia
- Edslev, Sofie Marie
- Stegger, Marc
- Sieber, Raphael Niklaus
- Lassauniere, Ria
- Fomsgaard, Anders
- Lillebaek, Troels
- Møller, Frederik Trier
- Møller, Camilla Holten
- Sydenham, Thomas Vognbjerg
- Steinke, Kat
- Castruita, José Alfredo Samaniego
- Schneider, Uffe Vest
- Marvig, Rasmus L
- Bybjerg-Grauholm, Jonas
- Gunalan, Vithiagaran
- Rasmussen, Morten
- Venue
- Eurosurveillance
- Published
- 2022-03-10
- Volume
- 27
- Issue
- 10
- ISSN
- 1025-496X (ISSN-L)
- 1560-7917
- PMC
- PMC8915403
- OpenAlex
- W4220665561
- Cited by
- 78
- References
- 24
- Citations by year
- 2025: 1 · 2024: 12 · 2023: 18 · 2022: 46 · 2021: 1
- FWCI
- 9.41
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Locations
- Eurosurveillance (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (publishedVersion, cc-by)
- University of Southern Denmark Research Portal (University of Southern Denmark) (publishedVersion, cc-by)
- Funders
- Statens Serum Institut
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Physical Sciences › Mathematics › Modeling and Simulation › COVID-19 epidemiological studies
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Keywords
- SARS-CoV-2, Omicron variant, molecular epidemiology, phylogenetic analysis, viral mutations, Denmark, capital region
- MeSH terms
- COVID-19, SARS-CoV-2, Denmark, Humans, Phylogeny, Molecular Epidemiology
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