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Cited by 93Consumer Attitudes and Food LabelingLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

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Scientific Opinion on the substantiation of a health claim related to 3 g/day plant sterols/stanols and lowering blood LDL‐cholesterol and reduced risk of (coronary) heart disease pursuant to Article 19 of Regulation (EC) No 1924/2006

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EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)·2012·EFSA Journal
DOI 10.2903/j.efsa.2012.2693PMC PMC13151794
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Abstract

Following an application from Unilever PLC and Unilever NV, submitted pursuant to Article 19 of Regulation (EC) No 1924/2006 via the Competent Authority of the United Kingdom, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of an application to modify the conditions of use of an authorised Article 14 claim related to 1.5 - 3.0 g plant sterols/stanols per day and lowering blood LDL-cholesterol by 7 - 12 % and reduced risk of (coronary) heart disease. The applicant has further requested that the minimum duration to obtain the effect be one to two weeks. The applicant provided a published systematic review and meta-analysis that evaluated the comparative efficacy of plant sterols and plant stanols for lowering blood LDL-cholesterol in healthy and hypercholesterolaemic subjects and an unpublished meta-analysis on 27 randomised controlled human studies on the LDL-lowering efficacy at a dose range between 2.6 and 3.4 g per day. On the basis of the data presented, the Panel concludes that plant sterols and stanol esters at daily intakes ranging from 1.5 to 3.0 g plant sterols/stanols in matrices approved by Regulation (EC) No 376/2010 (yellow fat spreads, dairy products, mayonnaise and salad dressings) have a similar efficacy on blood LDL-cholesterol lowering, that plant sterols and stanol esters at a daily intake of 3 g (range 2.6 g to 3.4 g) plant sterols/stanols in matrices approved by Regulation (EC) No 376…

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References 27 · Cited by 93

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Metadata

Authors
EFSA Panel on Dietetic Products, N. A. A. (.
Corresponding author
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
Venue
EFSA Journal
Publisher
Wiley
Published
2012-05
Volume
10
Issue
5
Pages
2693-2693
ISSN
1831-4732 (ISSN-L)
DOI
10.2903/j.efsa.2012.2693
PMC
PMC13151794
OpenAlex
W2032442065
Cited by
93
References
27
Citations by year
2026: 2 · 2025: 10 · 2024: 8 · 2023: 9 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 5 · 2018: 6 · 2017: 8 · 2016: 3 · 2015: 3 · 2014: 8 · 2013: 5 · 2012: 2
FWCI
5.56
Type
journal article
Language
en
Open access
Licence
Locations
  • EFSA Journal (publishedVersion, cc-by-nd)
  • PubMed (publishedVersion)
  • PubMed Central (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
  • Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU) (submittedVersion, other-oa)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Consumer Attitudes and Food Labeling
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords
phytosterols, plant stanols, stanol esters, LDL cholesterol lowering, health claims, mayonnaise, salad dressing, dairy products, hypercholesterolemia, dose-response relationship, duration of effect, Regulation (EC) No 1924/2006

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