Cited by 570Radiopharmaceutical Chemistry and ApplicationsRadioactivity and Radon MeasurementsMedical Imaging Techniques and Applications

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MIRD Pamphlet No. 22 (Abridged): Radiobiology and Dosimetry of α-Particle Emitters for Targeted Radionuclide Therapy

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Sgouros, George, Roeske, John C., McDevitt, Michael R., Palm, Stig, Allen, Barry J., Fisher, Darrell R., Brill, A. Bertrand, Song, Hong, Howell, Roger W., Akabani, Gamal·2010·Journal of Nuclear Medicine

DOI 10.2967/jnumed.108.058651PMC PMC5680544

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Abstract

The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle emitter therapy and to provide guidance and recommendations for human alpha-particle emitter dosimetry.

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THE STOPPING AND RANGE OF IONS IN SOLIDS
Ziegler, J. F. (1988) · Elsevier eBooks · doi:10.1016/b978-0-12-780621-1.50005-8 · Cited by 9,077
THE STOPPING AND RANGE OF IONS IN SOLIDS
Ziegler, J. F. (1984) · Elsevier eBooks · doi:10.1016/b978-0-12-780620-4.50007-0 · Cited by 5,892
Recommendations of the International Commission on Radiological Protection
(1961) · Postgraduate Medical Journal · doi:10.1136/pgmj.37.425.168-b · Cited by 5,868
The Stopping and Range of Ions in Matter
Ziegler, J. F., & Biersack, J. P. (1985) · Springer eBooks · doi:10.1007/978-1-4615-8103-1_3 · Cited by 4,360
Radiobiology for the Radiologist.
(1974) · Annals of Internal Medicine · doi:10.7326/0003-4819-80-3-438_1 · Cited by 3,498
The Stopping and Ranges of Ions in Matter
(1980) · Elsevier eBooks · doi:10.1016/c2013-0-02882-4 · Cited by 3,012
The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy
Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228
International Commission on Radiological Protection
(1969) · Radiology · doi:10.1148/93.6.1298 · Cited by 2,148
Basic anatomical and physiological data for use in radiological protection: reference values
Valentin, J. (2002) · Annals of the ICRP · doi:10.1016/s0146-6453(03)00002-2 · Cited by 2,024
Report of the task group on reference man
(1979) · Annals of the ICRP · doi:10.1016/0146-6453(79)90123-4 · Cited by 1,715

Show all 363 references

Research works printed but not linked: 32

2005, J Nucl Med., 46, 199S
1990, Antibody Immunoconjugates Radiopharm., 4, 85
1997, Blood., 90, 2245
2006, Cancer Biother Radiopharm., 21, 395
2006, Cancer Biother Radiopharm., 21, 396
2006, J Nucl Med., 47, 1049
International Commission on Radiological Protection. Relative Biological Effectiveness (RBE), Quality Factor (Q), and Radiation Weighting Factor (wR). Philadelphia, PA: Elsevier; 2004. ICRP publication 92.
1964, Cancer Res., 24, 683
1995, J Nucl Med., 36, 259
1989, Lancet., 2, 650
1997, J Nucl Med., 38, 727
2000, J Nucl Med., 41, 941
2007, Ann ICRP., 37, 1
1994, J Nucl Med., 35, 521
1993, J Nucl Med., 34, 1811
1988, Cancer Res., 48, 7022
1992, J Nucl Med., 33, 2167
1994, J Nucl Med., 35, 303
Fisher DR. The microdosimetry of monoclonal antibodies labeled with alpha emitters. In: Schlafke-Stelson AT, Watson EE, eds. Fourth International Radiopharmaceutical Dosimetry Symposium. Oak Ridge, TN: Oak Ridge Associated Universities; 1986:26–36.
Kellerer AM. Analysis of patterns of energy deposition: a survey of theoretical relations in microdosimetry. In: Ebert HG, ed. Proceedings of the Second Symposium on Microdosimetry. Brussels, Belgium: Commission of European Communities; 1970:107–134.
1997, J Nucl Med., 38, 1923
2004, J Nucl Med., 45, 129
2001, J Nucl Med., 42, 1216
1999, J Nucl Med., 40, 37S
1975, J Nucl Med., 16, 248
1999, J Nucl Med., 40, 1935
2002, J Nucl Med., 43, 97
2003, J Nucl Med., 44, 774
2005, J Nucl Med., 46, 1171
1969, J Nucl Med., 10, 7
1999, J Nucl Med., 40, 1947
Goodhead DT. Talk 23, Alpha Emitters, from Session 6, Effects from Specific Sources of Internal Radiation. Presented at: CERRIE Workshop; July 21–23, 2003; Oxford, U.K.

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Höllriegl, V., Petoussi-Henss, N., Ramos, J. C. O., & Li, W. B. (2020) · doi:10.21203/rs.3.rs-41574/v1
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(2023) · Advances in Bioengineering and Biomedical Science Research · doi:10.33140/abbsr.06.02.02
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Drozsdik, E. J. (2023) · Eötvös Loránd Tudományegyetem · doi:10.15476/elte.2022.108
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Roncali, L. (2023) · theses.fr (ABES) · doi:10.70675/4947469czfb82z4418z9665z8e75388fb994
Théranostique ciblant le PSMA : de la recherche clinique a la norme de soins standards
Calais, J. (2023) · theses.fr (ABES) · doi:10.70675/ef2b1f24z7ef1z40f2zb608z1a256bc8345a
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Cai, L., Aggarwal, S., Enninful, K. S., Chen, Y., Komarov, S., Thorek, D. L. J., Jha, A. K., & Tai, Y. (2024) · IEEE Nuclear Science Symposium and Medical Imaging Conference (NSS/MIC) · doi:10.1109/nss/mic/rtsd57108.2024.10657125
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Alkhani, L., Luce, J., Gabiña, P. M., & Roeske, J. C. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1394671
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Tulik, M., & Kunikowska, J. (2024) · Polish Journal of Medical Physics And Engineering · doi:10.2478/pjmpe-2024-0030
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Said, A., Hamdi, M., Salerno, I., Benabdallah, N., Turtle, N. F., Abou, D. S., Thomas, M. A., Mikell, J. K., & Thorek, D. L. J. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.12.11.627943
Étude préparatoire à la radioimmunothérapie pré-ciblée (PRIT) utilisant la chimie click sur le modèle de chiens spontanément atteints de cancer mammaire triple négatif.
Tabaja, Z. (2024) · theses.fr (ABES) · doi:10.70675/69c68896ze32fz4f84zacbcze5d2b8b02544
ASTATINE-211 AS AN EMERGING RADIOISOTOPE FOR TARGETED ALPHA THERAPY (TAT)
Apostolova, P., Gestin, J., Vranjes-Djuric, S., Arev, M., & Janevik-Ivanovska, E. (2024) · RAD Conference Proceedings. · doi:10.21175/radproc.2024.11

Authors: Sgouros, G., Roeske, J. C., McDevitt, M. R., Palm, S., Allen, B. J., Fisher, D. R., Brill, A. B., Song, H., Howell, R. W., & Akabani, G.
Affiliations: Johns Hopkins University (US)
Loyola University Medical Center (US)
Memorial Sloan Kettering Cancer Center (US)
International Atomic Energy Agency (AT)
Pacific Northwest National Laboratory (US)
Vanderbilt University (US)
Rutgers, The State University of New Jersey (US)
Texas A&M University (US)
ORCID: Roeske, John C.
McDevitt, Michael R.
Palm, Stig
Fisher, Darrell R.
Brill, A. Bertrand
Howell, Roger W.
Akabani, Gamal
Venue: Journal of Nuclear Medicine
Publisher: Society of Nuclear Medicine
Published: 2010-01-15
Volume: 51
Issue: 2
Pages: 311-328
ISSN: 0161-5505 (ISSN-L)
2159-662X
DOI: 10.2967/jnumed.108.058651
PMC: PMC5680544
OpenAlex: W2018649196
Cited by: 552
References: 363
Citations by year: 2026: 60 · 2025: 58 · 2024: 50 · 2023: 54 · 2022: 50 · 2021: 50 · 2020: 39 · 2019: 34 · 2018: 44 · 2017: 17 · 2016: 21 · 2015: 10 · 2014: 25 · 2013: 11 · 2012: 16
FWCI: 9.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Nuclear Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P50AG005136)
National Cancer Institute (R01CA109234, R41CA117599, P30CA008748)
National Institute of Biomedical Imaging and Bioengineering (R01EB001994)
National Center for Research Resources (R43RR015155)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
Physical Sciences › Physics and Astronomy › Radiation › Radioactivity and Radon Measurements
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords: alpha-emitting radionuclides, targeted alpha therapy, radiation biology, dosimetry, radionuclide conjugation, radiopharmaceuticals, cancer therapy
MeSH terms: Alpha Particles, Cell Survival, Clinical Trials as Topic, Dose-Response Relationship, Radiation, Female, Humans, Male, Neoplasms, Neoplasms, Radiation-Induced, Pamphlets, Radiation-Protective Agents, Radiobiology, Radioisotopes, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Relative Biological Effectiveness, Societies, Medical, Cell Death

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MIRD Pamphlet No. 22 (Abridged): Radiobiology and Dosimetry of α-Particle Emitters for Targeted Radionuclide Therapy

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