Cited by 570Radiopharmaceutical Chemistry and ApplicationsRadioactivity and Radon MeasurementsMedical Imaging Techniques and Applications

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MIRD Pamphlet No. 22 (Abridged): Radiobiology and Dosimetry of α-Particle Emitters for Targeted Radionuclide Therapy

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Sgouros, George, Roeske, John C., McDevitt, Michael R., Palm, Stig, Allen, Barry J., Fisher, Darrell R., Brill, A. Bertrand, Song, Hong, Howell, Roger W., Akabani, Gamal·2010·Journal of Nuclear Medicine

DOI 10.2967/jnumed.108.058651PMC PMC5680544

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Abstract

The potential of alpha-particle emitters to treat cancer has been recognized since the early 1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation chemistry, and the increased availability of alpha-emitters appropriate for clinical use, have recently led to patient trials of radiopharmaceuticals labeled with alpha-particle emitters. Although alpha-emitters have been studied for many decades, their current use in humans for targeted therapy is an important milestone. The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle emitter therapy and to provide guidance and recommendations for human alpha-particle emitter dosimetry.

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STUDIES ON X-RAY EFFECTS
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The Metabolism of Actinium in the Rat
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Absorbed fractions for alpha-particles in tissues of trabecular bone: considerations of marrow cellularity within the ICRP reference male.
Watchman, C. J., Jokisch, D. W., Patton, P. W., Rajon, D. A., Sgouros, G., & Bolch, W. E. (2005) · PubMed · Cited by 23
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Microdosimetry of radon progeny alpha particles in bronchial airway bifurcations
Fakir, H., HOFMANN, W., & Aubineau-Lanièce, I. (2005) · Radiation Protection Dosimetry · doi:10.1093/rpd/nci314 · Cited by 23
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Mutation and Inactivation of Cultured Mammalian Cells Exposed to Beams of Accelerated Heavy Ions
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211At‐labelling of polymer particles for radiotherapy: Synthesis, purification and stability
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In vitro and in vivo studies on the development of the α-emitting radionuclide bismuth 212 for intraperitoneal use against microscopic ovarian carcinoma
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Radiotoxicity of systemically administered [211At]astatide in B6C3F1 and BALB/c (nu/nu) mice: A long-term survival study with histologic analysis
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Synthesis, purification, and in vitro stability of 211At- and 125I-labeled amidobisphosphonates
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Experimental therapy of disseminated B-Cell lymphoma xenografts with 213Bi-labeled anti-CD74
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Preclinical studies of bismuth-213 labeled plasminogen activator inhibitor type 2 (PAI2) in a prostate cancer nude mouse xenograft model
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Radioprotection by Dmso Against the Biological Effects of Incorporated Radionuclides in Vivo: Comparison with other radioprotectors and evidence for indirect action of Auger electrons
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Cellular dose conversion factors for alpha-particle--emitting radionuclides of interest in radionuclide therapy.
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Biological Response to Nonuniform Distributions of210Po in Multicellular Clusters
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Calculations of Physical and Chemical Reactions Produced in Irradiated Water Containing DNA
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Determination of Absorbed Dose to Blood, Kidneys, Testes and Thyroid in Mice Injected With 211At and Comparison of Testes Mass and Sperm Number in X-irradiated and 211At Treated Mice
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Theoretical treatment of human haemopoietic stem cell survival following irradiation by alpha particles
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Influence of pretreatment with 3-amino-1-hydroxypropylidene-1,1-bisphosphonate (APB) on organ uptake of 211At and 125I-labeled amidobisphosphonates in mice
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Interlaboratory Comparison of Different Alpha-particle and Radon Sources
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No-Carrier-Added (4-Fluoro-3-[131I]iodobenzyl)guanidine and (3-[211At]Astato-4-fluorobenzyl)guanidine
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See all 570

Authors: Sgouros, G., Roeske, J. C., McDevitt, M. R., Palm, S., Allen, B. J., Fisher, D. R., Brill, A. B., Song, H., Howell, R. W., & Akabani, G.
Affiliations: Johns Hopkins University (US)
Loyola University Medical Center (US)
Memorial Sloan Kettering Cancer Center (US)
International Atomic Energy Agency (AT)
Pacific Northwest National Laboratory (US)
Vanderbilt University (US)
Rutgers, The State University of New Jersey (US)
Texas A&M University (US)
ORCID: Roeske, John C.
McDevitt, Michael R.
Palm, Stig
Fisher, Darrell R.
Brill, A. Bertrand
Howell, Roger W.
Akabani, Gamal
Venue: Journal of Nuclear Medicine
Publisher: Society of Nuclear Medicine
Published: 2010-01-15
Volume: 51
Issue: 2
Pages: 311-328
ISSN: 0161-5505 (ISSN-L)
2159-662X
DOI: 10.2967/jnumed.108.058651
PMC: PMC5680544
OpenAlex: W2018649196
Cited by: 552
References: 363
Citations by year: 2026: 60 · 2025: 58 · 2024: 50 · 2023: 54 · 2022: 50 · 2021: 50 · 2020: 39 · 2019: 34 · 2018: 44 · 2017: 17 · 2016: 21 · 2015: 10 · 2014: 25 · 2013: 11 · 2012: 16
FWCI: 9.79
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Nuclear Medicine (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (P50AG005136)
National Cancer Institute (R01CA109234, R41CA117599, P30CA008748)
National Institute of Biomedical Imaging and Bioengineering (R01EB001994)
National Center for Research Resources (R43RR015155)
Topics: Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
Physical Sciences › Physics and Astronomy › Radiation › Radioactivity and Radon Measurements
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
Keywords: alpha-emitting radionuclides, targeted alpha therapy, radiation biology, dosimetry, radionuclide conjugation, radiopharmaceuticals, cancer therapy
MeSH terms: Alpha Particles, Cell Survival, Clinical Trials as Topic, Dose-Response Relationship, Radiation, Female, Humans, Male, Neoplasms, Neoplasms, Radiation-Induced, Pamphlets, Radiation-Protective Agents, Radiobiology, Radioisotopes, Radiotherapy Dosage, Radiotherapy Planning, Computer-Assisted, Relative Biological Effectiveness, Societies, Medical, Cell Death

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