Raman's “Effect” on Molecular Imaging
Open accessAbstract
Raman spectroscopy is an optical technique that offers unsurpassed sensitivity and multiplexing capabilities to the field of molecular imaging. In the past, Raman spectroscopy had predominantly been used as an analytic tool for routine chemical analysis, but more recently, researchers have been able to harness its unique properties for imaging and spectral analysis of molecular interactions in cell populations and preclinical animal models. Additionally, researchers have already begun to translate this optical technique into a novel clinical diagnostic tool using various endoscopic strategies.
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SERS NPs are highly promising contrast agents for in vitro and ex vivo multiplexed proteomic imaging of cells and tissues.
“surface-enhanced Raman scattering nanoparticles (SERS NPs) are highly promising contrast agents for in vitro and ex vivo multiplexed proteomic imaging of cells and tissues.”
From Assessment of unmixing approaches for the quantitation of SERS nanoparticles in highly multiplexed spectral images (2024) · cites this paper as [5]
The Molecular Imaging Agent Approach section describes SERS nanoparticles as contrast agents for imaging cellular proteins and reports multiplexed detection of three proteins on stem cells, supporting the in vitro cell-imaging part. Our copy does not establish ex vivo multiplexed proteomic imaging of tissues; its discussion of excised bone in Future Developments concerns intrinsic Raman signals, not SERS nanoparticle protein imaging. No page numbers are provided in our copy. (LLM, conf=0.86)
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References 37 · Cited by 88
Research works printed but not linked: 1
- [17]17. Kircher MF, de la Zerda A, Jokerst J, et al. A brain tumor molecular imaging strategy using a novel triple-modality nanoparticle. Nat Med. In press.
- Authors
- Zavaleta, C. L., Kircher, M. F., & Gambhir, S. S.
- Affiliations
- Stanford Medicine (US)
- Memorial Sloan Kettering Cancer Center (US)
- Corresponding author
- Gambhir, Sanjiv S.
- Venue
- Journal of Nuclear Medicine
- Publisher
- Society of Nuclear Medicine
- Published
- 2011-08-25
- Volume
- 52
- Issue
- 12
- Pages
- 1839-1844
- ISSN
- 0161-5505 (ISSN-L)
- 2159-662X
- OpenAlex
- W2165063908
- Cited by
- 88
- References
- 37
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 2 · 2022: 9 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 5 · 2017: 9 · 2016: 4 · 2015: 8 · 2014: 12 · 2013: 12 · 2012: 11
- FWCI
- 6.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Nuclear Medicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Spectroscopy Techniques in Biomedical and Chemical Research
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- Raman spectroscopy, molecular imaging, Raman imaging, multiplexed imaging, cell populations, preclinical animal models, clinical diagnostics, endoscopic imaging, molecular interactions
- MeSH terms
- Animals, Cells, Humans, Spectrum Analysis, Raman, Molecular Imaging
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