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Dosimetry of 177 Lu-PSMA-617 in Metastatic Castration-Resistant Prostate Cancer: Correlations Between Pretherapeutic Imaging and Whole-Body Tumor Dosimetry with Treatment Outcomes
Open accessAbstract
177Lu-prostate-specific membrane antigen (PSMA)–617 enables targeted delivery of β-particle radiation to prostate cancer. We determined its radiation dosimetry and relationships to pretherapeutic imaging and outcomes. Methods: Thirty patients with prostate cancer receiving 177Lu-PSMA-617 within a prospective clinical trial (ACTRN12615000912583) were studied. Screening 68Ga-PSMA-11 PET/CT demonstrated high PSMA expression in all patients. After therapy, patients underwent quantitative SPECT/CT at 4, 24, and 96 h. Pharmacokinetic uptake and clearance at a voxel level were calculated and translated into absorbed dose using voxel S values. Volumes of interest were drawn on normal tissues and tumor to assess radiation dose, and a whole-body tumor dose was defined. Correlations between PSMA PET/CT parameters, dosimetry, and biochemical and therapeutic response were analyzed to identify relationships between absorbed dose, tumor burden, and patient physiology. Results: Mean absorbed dose to kidneys, submandibular and parotid glands, liver, spleen, and bone marrow was 0.39, 0.44, 0.58, 0.1, 0.06, and 0.11 Gy/MBq, respectively. Median whole-body tumor-absorbed dose was 11.55 Gy and correlated with prostate-specific antigen (PSA) response at 12 wk. A median dose of 14.1 Gy was observed in patients achieving a PSA decline of at least 50%, versus 9.6 Gy for those achieving a PSA decline of less than 50% (P < 0.01). Of 11 patients receiving a tumor dose of less than 10 Gy, only one achieved a PSA response of at least 50%. On screening PSMA PET, whole-body tumor SUVmean correlated with mean absorbed dose (r = 0.62), and SUVmax of the parotids correlated with absorbed dose (r = 0.67). There was an inverse correlation between tumor volume and mean dose to the parotids (r = −0.41) and kidneys (r = −0.43). The mean parotid dose was also reduced with increasing body mass (r = −0.41) and body surface area (r = −0.37). Conclusion:177Lu-PSMA-617 delivers high absorbed doses to tumor, with a significant correlation between whole-body tumor dose and PSA response. Patients receiving less than 10 Gy were unlikely to achieve a fall in PSA of at least 50%. Significant correlations between aspects of screening 68Ga-PET/CT and tumor and normal tissue dose were observed, providing a rationale for patient-specific dosing. Reduced salivary and kidney doses were observed in patients with a higher tumor burden. The parotid dose also reduced with increasing body mass and body surface area.
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“This scenario is common for many RPTs agents, and perhaps most prominently for prostate cancer ( 39 , 40 ), where metastatic dissemination is coincident with the marrow.”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [39]
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“In a phase 2 study of 28 patients who underwent 51 Cr-EDTA GFR measurement before and 3 mo after completion of 4 cycles of 177 Lu-PSMA, a very modest decline of approximately 12 mL/min in GFR was noted ( 39 , 68 , 69 ).”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [69]
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“The dosimetry studies of small molecules targeting PSMA such as 124 I/ 131 I-MIP-1095, or 177 Lu-PSMA-617 or 177 Lu-PSMA I&T have shown salivary glands commonly receive the highest radiation-absorbed dose among normal organs ( 69 , 74 ).”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [69]
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In the citing paper
“In a phase 2 study of 28 patients who underwent 51 Cr-EDTA GFR measurement before and 3 mo after completion of 4 cycles of 177 Lu-PSMA, a very modest decline of approximately 12 mL/min in GFR was noted ( 39 , 68 , 69 ).”
From Normal-Tissue Tolerance to Radiopharmaceutical Therapies, the Knowns and the Unknowns (2021) · cites this paper as [39]
Experimental — accuracy not yet measuredIn the citing paper
“High SUVmean values indicate high average PSMA expression levels, which may promote tumor binding and uptake of 177Lu-PSMA-617, leading to greater delivery of radiation and greater antitumor activity (18,19).”
From Quantitative 68 Ga-PSMA-11 PET and Clinical Outcomes in Metastatic Castration-resistant Prostate Cancer Following 177 Lu-PSMA-617 (VISION Trial) (2024) · cites this paper as [19]
In the citing paper
“High SUVmean values indicate high average PSMA expression levels, which may promote tumor binding and uptake of 177Lu-PSMA-617, leading to greater delivery of radiation and greater antitumor activity (18,19).”
From Quantitative 68 Ga-PSMA-11 PET and Clinical Outcomes in Metastatic Castration-resistant Prostate Cancer Following 177 Lu-PSMA-617 (VISION Trial) (2024) · cites this paper as [19]
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Cites
Stabin, M. G., Sparks, R. B., & Crowe, E. A. (2005) · PubMed · Cited by 1,340
Kratochwil, C., Bruchertseifer, F., Giesel, F. L., Weis, M., Verburg, F. A., Mottaghy, F. M., Kopka, K., Apostolidis, C., Haberkorn, U., & Morgenstern, A. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.178673 · Cited by 1,187
Hofman, M. S., Violet, J. A., Hicks, R. J., Ferdinandus, J., Thang, S. P., Akhurst, T. J., Iravani, A., Kong, G., Kumar, A. S. R., Murphy, D. G., et al. (2018) · The Lancet Oncology · doi:10.1016/s1470-2045(18)30198-0 · Cited by 1,184
Self-citationAfshar‐Oromieh, A., Avtzi, E., Giesel, F. L., Holland‐Letz, T., Linhart, H., Eder, M., Eisenhut, M., Boxler, S., Hadaschik, B. A., Kratochwil, C., et al. (2014) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2949-6 · Cited by 964
Afshar‐Oromieh, A., Malcher, A., Eder, M., Eisenhut, M., Linhart, H., Hadaschik, B. A., Holland‐Letz, T., Giesel, F. L., Kratochwil, C., Haufe, S., et al. (2012) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-012-2298-2 · Cited by 919
Rahbar, K., Ahmadzadehfar, H., Kratochwil, C., Haberkorn, U., Schäfers, M. A., Essler, M., Baum, R. P., Kulkarni, H., Schmidt, M. C., Drzezga, A. E., et al. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.183194 · Cited by 861
Jan, S., Benoit, D., Becheva, E., Carlier, T., Cassol-Brunner, F., Descourt, P., Frisson, T., Grevillot, L., Guigues, L., Maigne, L., et al. (2011) · Physics in Medicine and Biology · doi:10.1088/0031-9155/56/4/001 · Cited by 797
Maurer, T., Gschwend, J. E., Rauscher, I., Souvatzoglou, M., Haller, B., Weirich, G., Wester, H., Heck, M. M., Kübler, H. R., Beer, A. J., et al. (2015) · The Journal of Urology · doi:10.1016/j.juro.2015.12.025 · Cited by 778
Radiotherapy Dose–Volume Effects on Salivary Gland Function
Deasy, J. O., Moiseenko, V., Marks, L. B., Chao, K. S. C., Nam, J., & Eisbruch, A. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.06.090 · Cited by 591
Siegel, J. A., Thomas, S. R., Stubbs, J. B., Mg, S., Hays, M. T., Koral, K. F., Robertson, J. S., Howell, R. W., Wessels, B. W., Fisher, D. R., et al. (1999) · PubMed · Cited by 572
Morigi, J. J., Stricker, P. D., van Leeuwen, P. J., Tang, R., Ho, B., Nguyen, Q. A., Hruby, G., Fogarty, G. B., Jagavkar, R., Kneebone, A. B., et al. (2015) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.160382 · Cited by 571
Baum, R. P., Kulkarni, H., Schuchardt, C., Singh, A., Wirtz, M., Wiessalla, S., Schottelius, M., Müeller, D., Klette, I., & Wester, H. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.115.168443 · Cited by 532
Ross, J. S., Sheehan, C. E., Fisher, H. A. �., Kaufman, R. P., Kaur, P., Gray, K., Webb, I. J., Gray, G. S., Mosher, R. E., & Kallakury, B. (2003) · PubMed · Cited by 502
Klein, S., Staring, M., & Pluim, J. P. W. (2007) · IEEE Transactions on Image Processing · doi:10.1109/tip.2007.909412 · Cited by 429
Budäus, L., Leyh‐Bannurah, S., Salomon, G., Michl, U. H. G., Hans Heinzer, A., Huland, H., Graefen, M., Steuber, T. P., & Rosenbaum, C. M. (2015) · European Urology · doi:10.1016/j.eururo.2015.06.010 · Cited by 428
Tagawa, S. T., Milowsky, M. I., Morris, M. J., Vallabhajosula, S., Christos, P. J., Akhtar, N. H., Osborne, J. R., Goldsmith, S. J., Larson, S. M., Taskar, N. P., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-13-0231 · Cited by 427
Mannweiler, S., Amersdorfer, P., Trajanoski, S., Terrett, J. A., King, D., & Méhes, G. (2008) · Pathology & Oncology Research · doi:10.1007/s12253-008-9104-2 · Cited by 386
Zechmann, C. M., Afshar‐Oromieh, A., Armor, T., Stubbs, J. B., Mier, W., Hadaschik, B. A., Joyal, J. L., Kopka, K., Debus, J., Babich, J. W., et al. (2014) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-014-2713-y · Cited by 359
Delker, A., Fendler, W. P., Kratochwil, C., Brunegraf, A., Gosewisch, A., Gildehaus, F. J., Tritschler, S., Stief, C. G., Kopka, K., Haberkorn, U., et al. (2016) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3174-7 · Cited by 322
Radiation-Associated Kidney Injury
Dawson, L. A., Kavanagh, B. D., Paulino, A. C., Das, S. K., Miften, M. M., Li, X. A., Pan, C. C., Haken, R. K. T., & Schultheiss, T. E. (2010) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.02.089 · Cited by 317
EANM Dosimetry Committee guidelines for bone marrow and whole-body dosimetry
Hindorf, C., Glatting, G., Chiesa, C., Lindén, O., & Flux, G. (2010) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-010-1422-4 · Cited by 300
Ahmadzadehfar, H., Eppard, E., Kürpig, S., Fimmers, R., Yordanova, A., Schlenkhoff, C. D., Gärtner, F., Rogenhofer, S., & Essler, M. (2016) · Oncotarget · doi:10.18632/oncotarget.7245 · Cited by 282
Laßmann, M., Hänscheid, H., Chiesa, C., Hindorf, C., Flux, G., & Luster, M. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0761-x · Cited by 251
Oshida, M., Uno, K., Suzuki, M., Nagashima, T., Hashimoto, H., Yagata, H., Shishikura, T., IMAZEKI, K., & Nakajima, N. (1998) · Cancer · doi:10.1002/(sici)1097-0142(19980601)82:11 · Cited by 228
PSMA Ligands for Radionuclide Imaging and Therapy of Prostate Cancer: Clinical Status
Lütje, S., Heskamp, S., Cornelissen, A. S., Poeppel, T. D., van den Broek, S. A. M. W., Rosenbaum-Krumme, S. J., Bockisch, A., Gotthardt, M., Rijpkema, M., & Boerman, O. C. (2015) · Theranostics · doi:10.7150/thno.13348 · Cited by 224
Okamoto, S., Thieme, A., Allmann, J., D’Alessandria, C., Maurer, T., Retz, M., Tauber, R., Heck, M. M., Wester, H.-J., Tamaki, N., et al. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.178483 · Cited by 213
SUV of [68Ga]DOTATOC-PET/CT Predicts Response Probability of PRRT in Neuroendocrine Tumors
Kratochwil, C., Stefanova, M., Mavriopoulou, E., Holland‐Letz, T., Dimitrakopoulou‐Strauss, A., Afshar‐Oromieh, A., Mier, W., Haberkorn, U., & Giesel, F. L. (2014) · Molecular Imaging and Biology · doi:10.1007/s11307-014-0795-3 · Cited by 212
Kabasakal, L., AbuQbeitah, M., Aygün, A., Yeyin, N., Ocak, M., Demirci, E., & Toklu, T. (2015) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-015-3125-3 · Cited by 208
Garkavij, M., Nickel, M., Gleisner, K. S., Ljungberg, M. H., Ohlsson, T. G., Wingårdh, K., Strand, S., & Tennvall, J. (2010) · Cancer · doi:10.1002/cncr.24796 · Cited by 207
Heck, M. M., Retz, M. M., D’Alessandria, C., Rauscher, I., Scheidhauer, K., Maurer, T., Storz, E., Janssen, F., Schottelius, M., Wester, H., et al. (2016) · The Journal of Urology · doi:10.1016/j.juro.2016.02.2969 · Cited by 187
Individualized dosimetry in patients undergoing therapy with 177Lu-DOTA-D-Phe1-Tyr3-octreotate
Sandström, M., Garske, U., Granberg, D. O., Sundin, A., & Lundqvist, H. (2009) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-009-1216-8 · Cited by 182
Nephrotoxicity after PRRT with 177Lu-DOTA-octreotate
Bergsma, H., Konijnenberg, M., van der Zwan, W. A., Kam, B. L. R., Teunissen, J. J. M., Kooij, P. P. M., Mauff, K. A. L., Krenning, E. P., & Kwekkeboom, D. J. (2016) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-016-3382-9 · Cited by 180
Dose-rate effects in targeted radiotherapy
Dale, R. (1996) · Physics in Medicine and Biology · doi:10.1088/0031-9155/41/10/001 · Cited by 166
Ananias, H. J. K., van den Heuvel, M. C., Helfrich, W., & de Jong, I. J. (2009) · The Prostate · doi:10.1002/pros.20957 · Cited by 165
Beauregard, J., Hofman, M. S., Kong, G., & Hicks, R. J. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1937-3 · Cited by 151
Self-citationQuantitative 177 Lu SPECT (QSPECT) imaging using a commercially available SPECT/CT system
Beauregard, J., Hofman, M. S., Pereira, J. M., Eu, P., & Hicks, R. J. (2011) · Cancer Imaging · doi:10.1102/1470-7330.2011.0012 · Cited by 147
Self-citationPandit-Taskar, N. D., O’Donoghue, J. A., Ruan, S., Lyashchenko, S. K., Carrasquillo, J. A., Heller, G., Martinez, D. F., Cheal, S. M., Lewis, J. S., Fleisher, M., et al. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.176206 · Cited by 146
Meidenbauer, N., Harris, D. T., S̄pitler, L. E., & Whiteside, T. L. (2000) · The Prostate · doi:10.1002/(sici)1097-0045(20000501)43:2 · Cited by 121
11C-Acetate PET/CT in Localized Prostate Cancer: A Study with MRI and Histopathologic Correlation
Mena, E., Türkbey, B., Mani, H., Adler, S., Valera, V., Bernardo, M., Shah, V. P., Pohida, T. J., McKinney, Y. L., Kwarteng, G., et al. (2012) · Journal of Nuclear Medicine · doi:10.2967/jnumed.111.096032 · Cited by 119
Fendler, W. P., Kratochwil, C., Ahmadzadehfar, H., Rahbar, K., Baum, R. P., Schmidt, M. C., Pfestroff, A., Lützen, U., Prasad, V., Heinzel, A., et al. (2016) · Nuklearmedizin - NuclearMedicine · doi:10.1055/s-0037-1616480 · Cited by 113
Uptake of PSMA-ligands in normal tissues is dependent on tumor load in patients with prostate cancer
Gaertner, F. C., Halabi, K., Ahmadzadehfar, H., Kürpig, S., Eppard, E., Kotsikopoulos, C., Liakos, N., Bundschuh, R. A., Strunk, H. M., & Essler, M. (2017) · Oncotarget · doi:10.18632/oncotarget.19049 · Cited by 100
Sabet, A., Ezziddin, K., Pape, U., Reichman, K., Haslerud, T. M., Ahmadzadehfar, H., Biersack, H., Nagarajah, J., & Ezziddin, S. (2013) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-013-2601-x · Cited by 93
A Unique Folate Hydrolase, Prostate-Specific Membrane Antigen (PSMA): A Target For Immunotherapy?
Tasch, J. E., Gong, M., Sadelain, M., & Heston, W. D. W. (2001) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.v21.i1-3.160 · Cited by 92
Targeted Therapies for Prostate Cancer Against the Prostate Specific Membrane Antigen
Elsässer‐Beile, U., Bühler, P., & Wolf, P. (2009) · Current Drug Targets · doi:10.2174/138945009787354601 · Cited by 91
Ljungberg, M. H., & Gleisner, K. S. (2011) · Acta Oncologica · doi:10.3109/0284186x.2011.584559 · Cited by 89
Severe Dry Eye Syndrome After Radiotherapy for Head-and-Neck Tumors
Bhandare, N., Moiseenko, V., Song, W. Y., Morris, C. G., Bhatti, M. T., & Mendenhall, W. M. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2011.05.026 · Cited by 85
Hohberg, M., Eschner, W., Schmidt, M. C., Dietlein, M., Kobe, C., Fischer, T. H., Drzezga, A. E., & Wild, M. (2016) · Molecular Imaging and Biology · doi:10.1007/s11307-016-0942-0 · Cited by 85
Jackson, P. A., Beauregard, J., Hofman, M. S., Kron, T., Hogg, A., & Hicks, R. J. (2013) · Medical Physics · doi:10.1118/1.4824318 · Cited by 81
Self-citationYadav, M. P., Ballal, S., Tripathi, M., Damle, N. A., Sahoo, R. K., Seth, A., & Bal, C. (2016) · Nuclear Medicine Communications · doi:10.1097/mnm.0000000000000606 · Cited by 79
Kusumi, T., Koie, T., Tanaka, M., Matsumoto, K., Sato, F., Kusumi, A., Οhyama, C., & Kijima, H. (2008) · Pathology International · doi:10.1111/j.1440-1827.2008.02294.x · Cited by 40
Research works printed but not linked: 1
- Fendler, 2016, 177Lu-PSMA-617 therapy, dosimetry and follow-up in patients with metastatic castration-resistant prostate cancer [in German], Nucl Med (Stuttg)., 55, 123
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EANM procedure guidelines for radionuclide therapy with 177Lu-labelled PSMA-ligands (177Lu-PSMA-RLT)
Kratochwil, C., Fendler, W. P., Eiber, M., Baum, R. P., Bozkurt, M. F., Czernin, J. G., Bolton, R. C. D., Ezziddin, S., Forrer, F., Hicks, R. J., et al. (2019) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-019-04485-3 · Cited by 387
Self-citationBaum, R. P., Schuchardt, C., Singh, A., Chantadisai, M., Robiller, F., Zhang, J., Müeller, D., Eismant, A., Almaguel, F. A., Zboralski, D., et al. (2021) · Journal of Nuclear Medicine · doi:10.2967/jnumed.120.259192 · Cited by 379
Kratochwil, C., Fendler, W. P., Eiber, M., Hofman, M. S., Emmett, L., Calais, J., Osborne, J. R., Iravani, A., Koo, P. J., Lindenberg, L., et al. (2023) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-023-06255-8 · Cited by 339
Self-citationButeau, J. P., Martin, A. J., Emmett, L., Iravani, A., Sandhu, S., Joshua, A. M., Francis, R. J., Zhang, A. Y., Scott, A. M., Lee, S.-T., et al. (2022) · The Lancet Oncology · doi:10.1016/s1470-2045(22)00605-2 · Cited by 296
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Metadata
- Authors
- Violet, J., Jackson, P., Ferdinandus, J., Sandhu, S., Akhurst, T., Iravani, A., Kong, G., Kumar, A. R., Thang, S. P., Eu, P., Scalzo, M., Murphy, D., Williams, S., Hicks, R. J., & Hofman, M. S.
- Affiliations
- Peter MacCallum Cancer Centre (AU)
- The University of Melbourne (AU)
- ORCID
- Venue
- Journal of Nuclear Medicine
- Publisher
- Society of Nuclear Medicine
- Published
- 2018-10-05
- Volume
- 60
- Issue
- 4
- Pages
- 517-523
- ISSN
- 0161-5505 (ISSN-L)
- 2159-662X
- OpenAlex
- W2895593497
- Cited by
- 504
- References
- 52
- Citations by year
- 2026: 69 · 2025: 71 · 2024: 85 · 2023: 75 · 2022: 61 · 2021: 81 · 2020: 38 · 2019: 22 · 2018: 2
- FWCI
- 24.70
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Nuclear Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Australian Nuclear Science and Technology Organisation
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Health Sciences › Medicine › Urology › Prostate Cancer Diagnosis and Treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Keywords
- 177Lu-PSMA-617, prostate-specific membrane antigen, castration-resistant prostate cancer, metastatic prostate cancer, radiation dosimetry, absorbed dose, PSMA PET/CT, 68Ga-PSMA-11, quantitative SPECT/CT, parotid gland dose, kidney dose, PSA response, treatment outcome prediction, body mass
- MeSH terms
- Single Photon Emission Computed Tomography Computed Tomography, Dipeptides, Heterocyclic Compounds, 1-Ring, Humans, Lutetium, Male, Neoplasm Metastasis, Radioisotopes, Radiometry, Treatment Outcome, Prostate-Specific Antigen, Prostatic Neoplasms, Castration-Resistant
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