Role of glucocorticoids in coat depigmentation in animals selected for behavior
Abstract
The involvement of glucocorticoid hormones in the appearance of white spots during embryogenesis in domesticated gray rats was studied. It was shown that in fully pigmented gray rats, prenatal stress and exposure to dexamethasone on days 12–14 of gestation elicited a delay in the migration and development of melanoblasts in embryos. This led to a fourfold increase in the number of offspring with depigmentation on the ventral side of the body. It was also demonstrated that in adult offspring of mothers treated with dexamethasone, the response of the hypothalamo-pituitary-adrenal axis to the emotional stress was lower compared to the controls. The role of glucocorticoids in the appearance of coat depigmentation under animal domestication is discussed.
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Glucocorticoid levels are lower during gestation in both tame rats and foxes compared with aggressive strains.
“glucocorticoid levels are lower during gestation in both tame rats and foxes compared with aggressive strains (Oskina et al., 2010).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Oskina et al., 2010
In both the rat and duck studies, the effects of glucocorticoids on embryonic development take place long after neurulation and migration of neural crest cells away from the neural tube.
“In both the rat and duck studies, the effects of glucocorticoids on embryonic development take place long after neurulation and migration of neural crest cells away from the neural tube.”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Oskina et al., 2010
Suppression of glucocorticoid levels in pregnant aggressive females between days 12 and 14 of gestation leads to a concomitant reduction in embryonic glucocorticoids by day 20, which in turn leads to significant increases in depigmentation in neonate rats.
“Suppression of glucocorticoid levels in pregnant aggressive females between days 12 and 14 of gestation leads to a concomitant reduction in embryonic glucocorticoids by day 20.This, in turn, leads to significant increases in depigmentation in neonate rats (Oskina et al., 2010).”
From Glutamate receptors in domestication and modern human evolution (2020) · cites this paper as Oskina et al., 2010
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References 41 · Cited by 7
- Authors
- Oskina, I. N., Prasolova, L. A., Plyusnina, I. Z., & Trut, L. N.
- Affiliations
- Russian Academy of Sciences (RU)
- Corresponding author
- Oskina, I. N.
- Venue
- Cytology and Genetics
- Publisher
- Allerton Press
- Published
- 2010-10
- Volume
- 44
- Issue
- 5
- Pages
- 286-293
- ISSN
- 0095-4527 (ISSN-L)
- 1934-9440
- OpenAlex
- W2001640214
- Cited by
- 7
- References
- 41
- Citations by year
- 2022: 1 · 2019: 2 · 2016: 2 · 2013: 1
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Cytology and Genetics (publishedVersion)
- Funders
- Russian Academy of Sciences
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Keywords
- glucocorticoids, white spotting, melanoblast migration, prenatal stress, dexamethasone, hypothalamic-pituitary-adrenal axis, emotional stress response, domestication
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