Age-related loss of auditory sensitivity in two mouse genotypes
Abstract
Frequency-specific auditory brainstem responses (ABR) (frequency range 2-31.5 kHz) were used to describe age-dependent alterations in frequency sensitivity in CBA/ca (to 30 months) and C57BL/6J (to 16 months) mouse genotypes. The two strains displayed an age-related loss similar to that of humans, with a primary decline in high-frequency sensitivity. CBA mice showed a slow, yet gradual decrease in sensitivity to high- followed by low-frequency until 18 months of age and a rapid deterioration at all frequencies thereafter. C57 mice demonstrated precocious aging in auditory sensitivity in an unsteady rather than gradual manner. By testing the same individuals on repeated occasions it was shown that, for C57 mice, the degenerative process was more precipitous with three phases, and that the individual variability was larger than that of CBA mice. It is suggested that the two mouse genotypes can be used to express the different aspects of human presbycusis in individual variability and modes of gradual or staggered progression.
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There is a well-characterized loss of hearing around 7 months of age in the C57BL/6J strain.
“As there is a well-characterized loss of hearing around 7 months of age in the C57BL/6J strain [46–50]”
From Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion (2012) · cites this paper as [46]
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References 20 · Cited by 206
- Authors
- Li, H.-S., & Borg, E.
- Affiliations
- Karolinska Institutet (SE)
- Karolinska University Hospital (SE)
- Venue
- Acta Oto-Laryngologica
- Publisher
- Informa UK Limited
- Published
- 1991-01
- Volume
- 111
- Issue
- 4
- Pages
- 827-834
- ISSN
- 0001-6489 (ISSN-L)
- 1651-2251
- OpenAlex
- W2142357191
- Cited by
- 206
- References
- 20
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 10 · 2023: 9 · 2022: 9 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 7 · 2012: 6
- FWCI
- 2.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Acta Oto-Laryngologica (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Stiftelsen Tysta Skolan
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
- Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
- Keywords
- age-related hearing loss, auditory brainstem response, frequency sensitivity, high-frequency hearing loss, CBA mice, C57BL/6J mice, mouse strain differences, interindividual variability
- MeSH terms
- Aging, Animals, Auditory Threshold, Female, Genotype, Hearing Disorders, Mice, Inbred CBA, Mice, Inbred C57BL, Evoked Potentials, Auditory, Brain Stem, Mice
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