Synapse Regression in Depression: The Role of 5-HT Receptors in Modulating NMDA Receptor Function and Synaptic Plasticity

Depression is accompanied by an increase in activity in the amygdala and a decrease in the rostral anterior cingulate cortex (rACC), with the former attributed to a failure of the latter to exert its normal inhibitory influence. This failure is likely due to regression of synaptic connections bet…