Biomarker development in endometriosis
Open accessAbstract
Endometriosis is a common gynecologic disorder histologically characterized by the displacement of endometrial tissue to extra-uterine locations. A significant cause of infertility and pelvic pain, the global socioeconomic burden of endometriosis is staggering. Laparoscopy remains the gold standard for the diagnosis of the condition. However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 6-7 years from onset of symptoms to definitive diagnosis. Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression. The discovery of a sufficiently sensitive and specific biomarker for the non-surgical detection of endometriosis promises earlier diagnosis and prevention of deleterious sequelae, and remains a top research priority. The enigmatic pathophysiology of endometriosis presents unique challenges to biomarker development that are now well outlined. Within the past decade, significant advancements in understanding the molecular hallmarks of endometriosis have occurred, and promising biomarker candidates are emerging.
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Peritoneal macrophages in women with endometriosis have increased mRNA expression of cyclooxygenase-2, resulting in increased prostaglandin secretion.
“Peritoneal macrophages in women with endometriosis have increased mRNA expression of the cyclooxygenase-2 (COX-2), which resulted in increased prostaglandin secretion [64].”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [64]
Peritoneal macrophages in women with endometriosis secrete pro-inflammatory cytokines IL-6, TNF-α, IL-1β and IL-8 in increased amounts.
“They secrete pro-inflammatory cytokines, such as IL-6, TNF-α, IL-1β and IL-8, in increased amounts.”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [64]
An increased number of activated macrophages with a reduced ability to phagocytose in the peritoneal cavity is characteristic of women with endometriosis.
“An increased number of activated macrophages with a reduced ability to phagocytose in the peritoneal cavity is characteristic of women with endometriosis.”
From Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature) (2021) · cites this paper as [64]
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References 37 · Cited by 16
Research works printed but not linked: 7
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- Authors
- Burney, R. O.
- Affiliations
- Madigan Army Medical Center (US)
- Corresponding author
- Burney, Richard O.
- ORCID
- Burney, Richard O.
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 2014-08
- Volume
- 74
- Issue
- sup244
- Pages
- 75-81
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2124402834
- Cited by
- 16
- References
- 37
- Citations by year
- 2025: 1 · 2022: 3 · 2021: 5 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 2
- FWCI
- 0.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Ectopic Pregnancy Diagnosis and Management
- Health Sciences › Medicine › Obstetrics and Gynecology › Gynecological conditions and treatments
- Keywords
- endometriosis, biomarkers, non-surgical diagnosis, early diagnosis, infertility, pelvic pain, laparoscopy, disease pathophysiology, candidate biomarkers
- MeSH terms
- Endometriosis, Female, Humans, Menstrual Cycle, Biomarkers
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