Liver and Muscle Glycogen in Man after Glucose and Fructose Infusion
Abstract
The synthesis of liver and muscle glycogen was studied in healthy volunteers given glucose and fructose infusions. In the course of 4 hours 21 to 26 mmol sugar per kg body-weight was given. Before and after the infusion the glycogen content was determined in needle biopsy material from liver and muscle tissue. The mean increases of liver glycogen after fructose and glucose infusions were 274.6 ± 25.87 and 76.2 ± 9.92 mmol glucosyl units per kg wet weight liver tissue, respectively. In muscle tissue the increase of glycogen was of the same magnitude for both sugars, corresponding to 23.0 and 24.4 mmol glucosyl units per kg after fructose and glucose, respectively. A rough estimate concerning the distribution in the body of the sugar loads was also made. For both sugars it was calculated that more than half of the infused amount was stored as glycogen in liver and muscle tissue and less than 10 per cent could have been stored in fat tissue.
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During fructose infusion in humans, muscle glycogen content in skeletal muscle biopsies increases similarly as during glucose infusion.
“During fructose infusion in humans, muscle glycogen content in skeletal muscle biopsies increases similarly as during glucose infusion (29, 30).”
From Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans (1993) · cites this paper as [30]
Skeletal muscle accounts for an important proportion of fructose disposal.
“Finally, several lines of evidence indicate that, even though during fructose infusion the initial step of fructose metabolism is mainly hepatic, skeletal muscle accounts for an important proportion of fructose disposal (29–31).”
From Differential effects of hyperinsulinemia and carbohydrate metabolism on sympathetic nerve activity and muscle blood flow in humans (1993) · cites this paper as [30]
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References 28 · Cited by 178
- Authors
- Nilsson, L. H., & Hultman, E.
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1974-01
- Volume
- 33
- Issue
- 1
- Pages
- 5-10
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2104271292
- Cited by
- 178
- References
- 28
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 4 · 2019: 1 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 5 · 2013: 8 · 2012: 4
- FWCI
- 2.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Clinical and Laboratory Investigation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- glycogen synthesis, liver glycogen, skeletal muscle glycogen, glucose infusion, fructose infusion, carbohydrate metabolism, glycogen storage
- MeSH terms
- Adult, Biopsy, Needle, Blood Glucose, Female, Fructose, Glucose, Glycogen, Glycosuria, Humans, Infusions, Parenteral, Liver, Liver Glycogen, Male, Muscles, Stimulation, Chemical, Time Factors
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