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Studies on renal tubular protein reabsorption: Partial and near complete inhibition by certain amino acids
Abstract
Urinary excretion of albumin, free light chains of immunoglobulins and beta-2-microglobulin was measured after injection of certain amino acids and derivatives. Substances with a positively charged group located terminally in the molecule (ornithine, lysine, arginine, and the almost not metabolized epsilon-amino-caproic acid, and Cyclocaprone) proved to inhibit instantaneously the tubular protein reabsorption. Lysine is the most effective molecule tested. We hypothesize that the initial event in the normal tubular protein reabsorption is a binding between a free positive amino- or guanidino-group in the protein molecule and a negative site on the tubular cell surface. In an attempt to achieve complete inhibition of tubular protein reabsorption, large doses of lysine were injected intravenously. The maximal protein clearance rose from the exceedingly low baseline excretion to values probably representing near complete inhibition of protein reabsorption. The minimal value of albumin concentration in the glomerular filtrate was calculated to 2.6 mg/l.
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Citations
Cited by
Renal albumin absorption in physiology and pathology
Birn, H., & Christensen, E. I. (2006) · Kidney International · doi:10.1038/sj.ki.5000141 · Cited by 381
Rolleman, E., Valkema, R., de Jong, M., Kooij, P., & Krenning, E. (2003) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-002-0982-3 · Cited by 321
Behr, T. M., Goldenberg, D. M., & Becker, W. (1998) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s002590050216 · Cited by 274
Long-term oral creatine supplementation does not impair renal function in healthy athletes
POORTMANS, J. R., & FRANCAUX, M. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199908000-00005 · Cited by 215
Effect of short-term creatine supplementation on renal responses in men
Poortmans, J. R., Auquier, H., Renaut, V., Durussel, A., Saugy, M., & Brisson, G. R. (1997) · European Journal of Applied Physiology · doi:10.1007/s004210050291 · Cited by 170
Metadata
- Authors
- Mogensen, C. E., & Sølling, K.
- Venue
- Scandinavian Journal of Clinical and Laboratory Investigation
- Publisher
- Informa UK Limited
- Published
- 1977-01
- Volume
- 37
- Issue
- 6
- Pages
- 477-486
- ISSN
- 0036-5513 (ISSN-L)
- 1502-7686
- OpenAlex
- W2087812051
- Cited by
- 233
- References
- 0
- FWCI
- 5.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Mogensen, C. E., & Sølling, K. (1977). Studies on renal tubular protein reabsorption: Partial and near complete inhibition by certain amino acids. Scandinavian Journal of Clinical and Laboratory Investigation. https://doi.org/10.3109/00365517709101835
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