The DOI matches its Crossref record.
The risk of colorectal cancer in ulcerative colitis. An epidemiologic study
Abstract
Patients with a definite diagnosis of ulcerative colitis in Stockholm County during the 35-year period 1945-79 were identified and followed up with regard to the development of cancer of the colon. We found 25 patients who had developed 31 cancers. In 24 of 25 cases this occurred in patients with total colitis. The cumulative risk of developing cancer for patients with total colitis at follow-up study was calculated by means of life-table methods. It was 13% at 25 years (SD +/- 4.2%) among patients diagnosed in 1945-79, compared with the 1.9% expected in a population matched for age and sex. Among patients diagnosed in 1955-79 the risk was approximately 5% at 20 years (SD +/- 3.0%), compared with 1.4% for the background population. The cancer risk for all patients with colitis was higher but not significantly higher than that of the general population. The outcome of patients who developed cancer was dependent on histologic staging (Dukes's) at surgery but not on age at cancer diagnosis.
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Chronic inflammation and flares of disease are risk factors for CAC.
“In agreement with this link, chronic inflammation and flares of disease have been identified as risk factors for CAC.37–39”
From PU.1-driven Th9 Cells Promote Colorectal Cancer in Experimental Colitis Models Through Il-6 Effects in Intestinal Epithelial Cells (2022) · cites this paper as [39]
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Research works printed but not linked: 11
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Cited by
Sorted by citations
Gerlach, K., Popp, V., Wirtz, S., Al-Saifi, R., Gonzalez Acera, M., Atreya, R., Dregelies, T., Vieth, M., Fichtner-Feigl, S., McKenzie, A. N. J., et al. (2022) · Journal of Crohn's and Colitis · doi:10.1093/ecco-jcc/jjac097 · Cited by 25
Metadata
- Authors
- Broström, O., Löfberg, R., Nordenvall, B., Öst, Å., & Hellers, G.
- Affiliations
- Danderyds sjukhus (SE)
- ORCID
- Öst, Å.
- Venue
- Scandinavian Journal of Gastroenterology
- Publisher
- Informa UK Limited
- Published
- 1987-01
- Volume
- 22
- Issue
- 10
- Pages
- 1193-1199
- ISSN
- 0036-5521 (ISSN-L)
- 1502-7708
- OpenAlex
- W2056075928
- Cited by
- 153
- References
- 0
- Citations by year
- 2025: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 3 · 2017: 4 · 2016: 3 · 2015: 1 · 2014: 5 · 2013: 6 · 2012: 3
- FWCI
- 2.68
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Scandinavian Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Gastroenterology › Inflammatory Bowel Disease
- Health Sciences › Medicine › Oncology › Colorectal Cancer Screening and Detection
- Health Sciences › Medicine › Oncology › Colorectal Cancer Surgical Treatments
- Keywords
- ulcerative colitis, colorectal cancer, cancer risk, total colitis, cumulative incidence, life table analysis, Dukes staging, age at cancer diagnosis, long-term follow-up
- MeSH terms
- Adult, Child, Colitis, Ulcerative, Colonic Neoplasms, Female, Humans, Male, Middle Aged, Prognosis, Rectal Neoplasms, Risk Factors, Sweden
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