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Serum Enzymes as Indicators of Chemically Induced Liver Damage
Abstract
Rats were dosed with CCl4 or diethylamine to induce liver injury. The time and magnitude of peak liver injury were assessed by histopathological examination of liver specimens taken at intervals after dosing. Serum enzymes were measured at the same intervals. Serum ornithine carbamyl transferase (SOCT) activity increased at least 6-fold in animals that showed liver damage by histopathology, and fell again as the injuries resolved. Measurements of other enzymes were less sensitive. SOCT measurements appear to be as sensitive a method as histopathology for detecting liver damage caused by administering xenobiotics. Since serum enzyme measurements do not require that the animals be sacrificed, they can be used for repeated examinations of the same animals, thus increasing the likelihood of detecting transient injury.
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Hepatic necrosis leads to elevated levels of serum enzymes AST and ALT which are indicative of cellular leakage and loss of functional integrity of cell membrane in the liver.
“Hepatic necrosis leads to the elevated levels of serum enzymes AST and ALT which are indicative of cellular leakage and loss of functional integrity of cell membrane in the liver. 41”
From Caralluma umbellata Haw. protects liver against paracetamol toxicity and inhibits CYP2E1 (2017) · cites this paper as [41]
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Caralluma umbellata Haw. protects liver against paracetamol toxicity and inhibits CYP2E1
Bellamakondi, P. K., Godavarthi, A., & Ibrahim, M. (2017) · BioImpacts · doi:10.15171/bi.2018.04 · Cited by 15
Metadata
- Authors
- Drotman, R. B., & Lawhorn, G. T.
- Affiliations
- Procter & Gamble (United States) (US)
- Venue
- Drug and Chemical Toxicology
- Publisher
- Informa UK Limited
- Published
- 1978-01
- Volume
- 1
- Issue
- 2
- Pages
- 163-171
- ISSN
- 0148-0545 (ISSN-L)
- 1525-6014
- OpenAlex
- W2047165626
- Cited by
- 340
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 17 · 2019: 15 · 2018: 8 · 2017: 22 · 2016: 18 · 2015: 19 · 2014: 21 · 2013: 38 · 2012: 26
- FWCI
- 0.59
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Drug and Chemical Toxicology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Drug-Induced Hepatotoxicity and Protection
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- serum enzymes, liver injury, carbon tetrachloride, diethylamine, ornithine carbamyl transferase, histopathology comparison, rats
- MeSH terms
- Animals, Carbon Tetrachloride Poisoning, Diethylamines, Enzymes, Liver, Male, Time Factors, Rats, Chemical and Drug Induced Liver Injury
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