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Cited by 4Parathyroid Disorders and TreatmentsAluminum toxicity and tolerance in plants and animalsHeavy Metal Exposure and Toxicity

The DOI matches its Crossref record.

Parathyroid Glands in Chronic Aluminum Intoxication

Cournot-Witmer, Giulia, Plachot, Jean-Jacques·1990·Ultrastructural Pathology
DOI 10.3109/01913129009076125
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Abstract

In chronic renal failure, aluminum overload may influence parathyroid function. In a study of possible aluminum-induced parathyroid abnormalities, parathyroid glands from nine parathyroidectomized patients on hemodialysis were examined by light and electron microscopy and by X-ray microanalysis. Aluminum overload was assessed by the presence of stainable aluminum (aluminum surface, 23.3% +/- 11% of total surface) in bone biopsy specimens. The mean plasma aluminum concentration was 7.7 +/- 1.9 mumol/L. All patients but one had elevated plasma concentrations of immunoreactive parathyroid hormone as well as osteitis fibrosa. The aluminum concentrations in bone and parathyroid gland from these patients were significantly higher than those in tissue from patients on hemodialysis without stainable bone aluminum. Abundant aluminum deposits were present in parathyroid chief cell cytoplasm in lipoid bodies, lipofuscin granules, and mitochondria. These cells exhibited features of active hormonal synthesis and contained numerous secretory granules. The data show that in the parathyroid glands of these aluminum-intoxicated patients the presence of aluminum deposits neither induced cellular damage or chief cell necrosis nor interfered with the production of parathyroid hormone.

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Research works printed but not linked: 26

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Metadata

Authors
Cournot-Witmer, G., & Plachot, J.-J.
Affiliations
Hôpital Necker-Enfants Malades (FR)
Venue
Ultrastructural Pathology
Publisher
Informa UK Limited
Published
1990-01
Volume
14
Issue
3
Pages
211-219
ISSN
  • 0191-3123 (ISSN-L)
  • 1521-0758
DOI
10.3109/01913129009076125
OpenAlex
W2120263139
Cited by
4
References
0
Citations by year
2026: 1 · 2019: 1
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
  • Ultrastructural Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Aluminum toxicity and tolerance in plants and animals
  • Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
Keywords
parathyroid glands, parathyroid hormone, hemodialysis, chronic kidney disease, aluminum overload, osteitis fibrosa, parathyroid chief cells, lipofuscin granules
MeSH terms
Adult, Aged, Aluminum, Bone and Bones, Cell Nucleus, Cytoplasm, Cytoplasmic Granules, Female, Renal Dialysis, Humans, Hyperplasia, Kidney Failure, Chronic, Male, Microscopy, Electron, Middle Aged, Osteoblasts, Osteoclasts, Parathyroid Diseases, Parathyroid Glands, Parathyroid Hormone

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