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Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin
Abstract
A new sustained-release dosage form of nitrofurantoin (NF) as microcapsules has been prepared by a mild chitosan/calcium alginate microencapsulation process. These microcapsules have been prepared by adding, dropwise, a solution of sodium alginate containing NF into a chitosan-CaCl(2) system. About 70-80% of the drug is released into phosphate buffer, pH = 7.4 within 6 h. Drug release into the gastric medium is found to be relatively slow compared to that into the intestinal medium. From scanning electron microscopic studies, it appears that the chitosan modifies the NF-alginate microspheres. These findings suggest the possibility of modifying the formulation to obtain the controlled release of NF in an oral sustained-delivery system.
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Citations
Cited by
Alginate in Drug Delivery Systems
Tønnesen, H. H., & Karlsen, J. (2002) · Drug Development and Industrial Pharmacy · doi:10.1081/ddc-120003853 · Cited by 1,509
Chitosan: A Unique Polysaccharide for Drug Delivery
Felt, O., Buri, P., & Gurny, R. (1998) · Drug Development and Industrial Pharmacy · doi:10.3109/03639049809089942 · Cited by 769
Mi, F.-L., Sung, H.-W., & Shyu, S.-S. (2002) · Carbohydrate Polymers · doi:10.1016/s0144-8617(01)00212-0 · Cited by 332
Alginate/chitosan particulate systems for sodium diclofenac release
González-Rodrı́guez, M. L., Holgado, M. A., Sánchez-Lafuente, C., Rabasco, A. M., & Fini, A. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00915-2 · Cited by 276
Chitosan: An Attractive Biocompatible Polymer for Microencapsulation
Peniche, C., Argüelles‐Monal, W., Peniche, H., & Acosta, N. (2003) · Macromolecular Bioscience · doi:10.1002/mabi.200300019 · Cited by 272
Metadata
- Authors
- Hari, P. R., Chandy, T., & Sharma, C. P.
- Venue
- Journal of Microencapsulation
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 13
- Issue
- 3
- Pages
- 319-329
- ISSN
- 0265-2048 (ISSN-L)
- 1464-5246
- OpenAlex
- W2015449015
- Cited by
- 187
- References
- 0
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hari, P. R., Chandy, T., & Sharma, C. P. (1996). Chitosan/calcium alginate microcapsules for intestinal delivery of nitrofurantoin. Journal of Microencapsulation. https://doi.org/10.3109/02652049609026019
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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