Magnetic nanoparticle hyperthermia enhancement of cisplatin chemotherapy cancer treatment
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PURPOSE: The purpose of this study was to examine the therapeutic effect of magnetic nanoparticle hyperthermia (mNPH) combined with systemic cisplatin chemotherapy in a murine mammary adenocarcinoma model (MTGB). MATERIALS AND METHODS: An alternating magnetic field (35.8 kA/m at 165 kHz) was used to activate 110 nm hydroxyethyl starch-coated magnetic nanoparticles (mNP) to a thermal dose of 60 min at 43 °C. Intratumoral mNP were delivered at 7.5 mg of Fe/cm(3) of tumour (four equal tumour quadrants). Intraperitoneal cisplatin at 5 mg/kg body weight was administered 1 h prior to mNPH. Tumour regrowth delay time was used to assess the treatment efficacy. RESULTS: mNP hyperthermia, combined with cisplatin, was 1.7 times more effective than mNP hyperthermia alone and 1.4 times more effective than cisplatin alone (p < 0.05). CONCLUSIONS: Our results demonstrate that mNP hyperthermia can result in a safe and significant therapeutic enhancement for cisplatin cancer therapy.
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Animal models can imitate the TME to provide essential information regarding tumor growth and tumor response to drug compounds in vivo for the study of pharmacokinetics and mechanism of action after drug treatment.
“Alternatively, animal models, as the gold standard in cancer biology, can imitate the TME to provide essential information regarding tumor growth and tumor response to drug compounds in vivo for the study of the pharmacokinetics and mechanism of action after drug treatment26–30.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [27]
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References 27 · Cited by 72
- Authors
- Petryk, A. A., Giustini, A. J., Gottesman, R. E., Kaufman, P. A., & Hoopes, P. J.
- Affiliations
- Dartmouth College (US)
- Corresponding author
- Petryk, Alicia A.
- Venue
- International Journal of Hyperthermia
- Publisher
- Informa UK Limited
- Published
- 2013-10-21
- Volume
- 29
- Issue
- 8
- Pages
- 845-851
- ISSN
- 0265-6736 (ISSN-L)
- 1464-5157
- PMC
- PMC4996113
- OpenAlex
- W2037780637
- Cited by
- 72
- References
- 27
- Citations by year
- 2025: 6 · 2024: 6 · 2023: 1 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 3 · 2017: 7 · 2016: 12 · 2015: 12 · 2014: 5 · 2013: 1
- FWCI
- 5.51
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Hyperthermia (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (U54CA151662)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Characterization and Applications of Magnetic Nanoparticles
- Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- magnetic hyperthermia, cisplatin, combination chemotherapy, alternating magnetic field, mammary adenocarcinoma
- MeSH terms
- Adenocarcinoma, Animals, Antineoplastic Agents, Breast Neoplasms, Cisplatin, Combined Modality Therapy, Female, Hyperthermia, Induced, Mice, Inbred C3H, Tumor Burden, Mice, Magnetite Nanoparticles
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