Anterior pituitary dysfunction in moderate-to-severe chronic traumatic brain injury patients and the influence on functional outcome
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Objective The objective of this study is to determine the prevalence of anterior pituitary dysfunction in moderate-to-severe chronic traumatic brain injury (TBI) patients. The investigation of a relationship between pituitary hormonal status and body mass index (BMI) in TBI patients by observing changes in BMI was conducted as well as an assessment of whether there is a difference in functional outcome related to anterior pituitary dysfunction in TBI patients. Methods Forty-five TBI patients and 30 normal controls underwent a series of standard endocrine tests for anterior pituitary hormone function. It was studied whether changes in BMI correlated with anterior pituitary hormone levels. This study also compared changes in mini-mental state examination (K-MMSE) and functional independence measure (FIM) scores between patients in the hormone-sufficient and -deficient groups. Results Anterior pituitary dysfunction was found in 31.1% of TBI patients. Changes in BMI statistically correlated with IGF-1 and basal cortisol levels. A meaningful difference was found between the hormone-sufficient and -deficient groups in light of the K-MMSE and FIM score gains. Conclusions These findings strongly suggest that patients who suffer head trauma should be routinely tested for anterior pituitary hormone deficiency.
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Post-traumatic hypopituitarism (PTHP) is a common and clinically significant consequence of traumatic brain injury (TBI).
“Over the last 15 years, a significant body of evidence has emerged demonstrating that post-traumatic hypopituitarism (PTHP) is a common and clinically significant consequence of TBI.”
From Post-Traumatic Hypopituitarism—Who Should Be Screened, When, and How? (2018) · cites this paper as [4]
PTHP contributes significantly to morbidity and possibly mortality in patients with moderate or severe TBI.
“Over the recent 15 years, numerous research studies have documented a high rate of pituitary gland dysfunction following moderate or severe TBI with evidence that post-traumatic hypopituitarism (PTHP) contributes significantly to the morbidity and possibly mortality in those patients (4).”
From Post-Traumatic Hypopituitarism—Who Should Be Screened, When, and How? (2018) · cites this paper as [4]
Anterior pituitary hormone deficiency has a negative impact on functional outcome at 6 months post TBI as assessed by mini-mental state exam and functional independence measure scores.
“Recent data seem to confirm that anterior pituitary hormone deficiency has a negative impact on functional outcome at 6 months post TBI as assessed by mini-mental state exam and functional independence measure scores (4).”
From Post-Traumatic Hypopituitarism—Who Should Be Screened, When, and How? (2018) · cites this paper as [4]
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References 18 · Cited by 49
- Authors
- Park, K. D., Kim, D. Y., Lee, J. K., Nam, H.-S., & Park, Y.-G.
- Affiliations
- Gachon University (KR)
- Yonsei University (KR)
- Hallym University (KR)
- Corresponding author
- Park, Yoon-Ghil
- Venue
- Brain Injury
- Publisher
- Informa UK Limited
- Published
- 2010-09-09
- Volume
- 24
- Issue
- 11
- Pages
- 1330-1335
- ISSN
- 0269-9052 (ISSN-L)
- 1362-301X
- OpenAlex
- W1977485109
- Cited by
- 49
- References
- 18
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 3.26
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- Locations
- Brain Injury (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Keywords
- anterior pituitary dysfunction, chronic traumatic brain injury, pituitary hormone deficiency, body mass index, insulin-like growth factor I, cortisol, functional outcome, cognitive function, functional independence, endocrine testing
- MeSH terms
- Adult, Brain Injuries, Chronic Disease, Female, Humans, Hypopituitarism, Male, Pituitary Gland, Anterior, Pituitary Hormones, Anterior, Body Mass Index
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