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Two new Later Stone Age sites from the Final Pleistocene in the Falémé Valley, eastern Senegal

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Genome-wide interrogation of transfer RNA-derived small RNAs in a mouse model of traumatic brain injury

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BDNF: New Views of an Old Player in Traumatic Brain Injury

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Research progress on pleiotropic neuroprotective drugs for traumatic brain injury

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Contraceptive drugs mitigate experimental stroke-induced brain injury

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Recent Preclinical Insights Into the Treatment of Chronic Traumatic Encephalopathy

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Recovery after moderate to severe TBI and factors influencing functional outcome: What you need to know

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Evaluating the neurotherapeutic potential of a water-soluble progesterone analog after traumatic brain injury in rats

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An Activity‐Based Nanosensor for Minimally‐Invasive Measurement of Protease Activity in Traumatic Brain Injury

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Evaluation of antioxidant, anti-inflammatory, anticancer activities and molecular docking of Moringa oleifera seed oil extract against experimental model of Ehrlich ascites carcinoma in Swiss female albino mice

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Resilience to Injury: A New Approach to Neuroprotection?

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Progesterone in the treatment of neonatal arterial ischemic stroke and acute seizures: Role of BDNF/TrkB signaling

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Sex differences in the effects of mild traumatic brain injury and progesterone treatment on anxiety-like behavior and fear conditioning in rats

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Neurosteroid Receptor Modulators for Treating Traumatic Brain Injury

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Neurobehavioral and inflammatory responses following traumatic brain injury in male and female mice

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Development of a novel progesterone analog in the treatment of traumatic brain injury

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Traumatic brain injury and frontal lobe plasticity

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Treating head injury using a novel vasopressin 1a receptor antagonist

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A 3-month-delayed treatment with anatabine improves chronic outcomes in two different models of repetitive mild traumatic brain injury in hTau mice

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Sameerpannag Ras Mixture (SRM) improved neurobehavioral deficits following acute ischemic stroke by attenuating neuroinflammatory response

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Neuroprotective response and efficacy of intravenous administration of mesenchymal stem cells in traumatic brain injury mice

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Neurotherapeutic Potential of Water-Soluble pH-Responsive Prodrugs of EIDD-036 in Traumatic Brain Injury

Fritzemeier, R. G., van der Westhuyzen, A. E., D’Erasmo, M. P., Sharma, S. K., Bartsch, P. W., Hodson, L. E., Liu, K., Wali, B., Sayeed, I., & Liotta, D. C. (2023) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01484 · Cited by 14

The Serum Changes of Neuron-Specific Enolase and Intercellular Adhesion Molecule-1 in Patients With Diffuse Axonal Injury Following Progesterone Administration: A Randomized Clinical Trial

Shahrokhi, N., Soltani, Z., Khaksari, M., Karamouzian, S., Mofid, B., & Asadikaram, G. (2016) · Archives of Trauma Research · doi:10.5812/atr.37005 · Cited by 14

Why Did the Phase III Clinical Trials for Progesterone in TBI Fail? An Analysis of Three Potentially Critical Factors

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Therapeutic strategies to target acute and long-term sequelae of pediatric traumatic brain injury

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Sex, Genes, and Traumatic Brain Injury (TBI): A Call for a Gender Inclusive Approach to the Study of TBI in the Lab

Duncan, K. A., & Garijo-Garde, S. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.681599 · Cited by 15

Increasing Rigor of Preclinical Research to Maximize Opportunities for Translation

Radabaugh, H. L., Ferguson, A. R., Bramlett, H. M., & Dietrich, W. D. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01400-5 · Cited by 13

Fluid-Based Protein Biomarkers in Traumatic Brain Injury: The View from the Bedside

Agoston, D. V., & Helmy, A. E. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242216267 · Cited by 13

Organoids and chimeras: the hopeful fusion transforming traumatic brain injury research

Bellotti, C., Samudyata, S., Thams, S., Sellgren, C. M., & Rostami, E. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01845-5 · Cited by 12

PEGylated Multimeric RNA Nanoparticles for siRNA Delivery in Traumatic Brain Injury

Han, S. W., Yoo, W., Carton, O., Joo, J., & Kwon, E. J. (2024) · Small · doi:10.1002/smll.202405806 · Cited by 13

Prospective Harmonization, Common Data Elements, and Sharing Strategies for Multicenter Pre-Clinical Traumatic Brain Injury Research in the Translational Outcomes Project in Neurotrauma Consortium

Wanner, I. B., McCabe, J. T., Huie, J. R., Harris, N. G., Paydar, A., McMann-Chapman, C., Tobar, A., Korotcov, A. V., Burns, M. P., Koehler, R. C., et al. (2025) · Journal of Neurotrauma · doi:10.1089/neu.2023.0653 · Cited by 13

Pharmacological Optimization for Successful Traumatic Brain Injury Drug Development

Poloyac, S. M., Bertz, R., McDermott, L. A., & Marathe, P. (2019) · Journal of Neurotrauma · doi:10.1089/neu.2018.6295 · Cited by 13

Translational Genomics in Neurocritical Care: a Review

Myserlis, E. P., Radmanesh, F., & Anderson, C. D. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00838-1 · Cited by 12

The Relationship Between Inflammation and the Development of Cerebral Ischaemia and Hypoxia in Traumatic Brain Injury—A Narrative Review

Nimmo, A. J., & Younsi, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26168066 · Cited by 14

Are GABAergic drugs beneficial in providing neuroprotection after traumatic brain injuries? A comprehensive literature review of preclinical studies

Sudhakar, S. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1109406 · Cited by 12

Upregulation of multiple toll-like receptors in ferret brain after blast exposure: Potential targets for treatment

Govindarajulu, M., Patel, M. Y., Wilder, D. M., Krishnan, J. K. S., LaValle, C. R., Pandya, J. D., Shear, D. A., Hefeneider, S. H., Long, J. B., & Arun, P. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137364 · Cited by 15

Genetic Modulators of Traumatic Brain Injury in Animal Models and the Impact of Sex-Dependent Effects

Inampudi, C., Ciccotosto, G. D., Cappai, R., & Crack, P. J. (2020) · Journal of Neurotrauma · doi:10.1089/neu.2019.6955 · Cited by 12

Admission circulating monocytes level is an independent predictor of outcome in traumatic brain injury

Li, Z., Wu, X., Wu, X., Yu, J., Yuan, Q., Du, Z., & Hu, J. (2018) · Brain Injury · doi:10.1080/02699052.2018.1429023 · Cited by 12

Systemic Estrone Production and Injury-Induced Sex Hormone Steroidogenesis after Severe Traumatic Brain Injury: A Prognostic Indicator of Traumatic Brain Injury-Related Mortality

Rakholia, M. V., Kumar, R. G., Oh, B., Ranganathan, P. R., Berga, S., Kochanek, P., & Wagner, A. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5782 · Cited by 13

ApoE Mimetic Peptides as Therapy for Traumatic Brain Injury

Laskowitz, D. T., & Wyck, D. W. V. (2023) · Neurotherapeutics · doi:10.1007/s13311-023-01413-0 · Cited by 12

Quantitative multimodal imaging in traumatic brain injuries producing impaired cognition

Shah, S. A., Lowder, R. J., & Kuceyeski, A. F. (2020) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000872 · Cited by 12

Effects of Progesterone on Preclinical Animal Models of Traumatic Brain Injury: Systematic Review and Meta-analysis

Nasre‐Nasser, R. G., Severo, M. M. R., Pires, G. N., Hort, M. A., & Arbo, B. D. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02970-9 · Cited by 11

KDM4A, involved in the inflammatory and oxidative stress caused by traumatic brain injury-hemorrhagic shock, partly through the regulation of the microglia M1 polarization

Cai, J., Yang, Y., Han, J., Gao, Y., Li, X., & Ge, X. (2023) · BMC Neuroscience · doi:10.1186/s12868-023-00784-6 · Cited by 11

Closed-Head TBI Model of Multiple Morbidity

Thompson, F. J., Hou, J., & Bose, P. (2016) · Methods in molecular biology · doi:10.1007/978-1-4939-3816-2_28 · Cited by 11

Prehospital Detection of Life-Threatening Intracranial Pathology: An Unmet Need for Severe TBI in Austere, Rural, and Remote Areas

Whiting, M. D., Dengler, B. A., Rodriguez, C. L., Blodgett, D. W., Cohen, A. B., Januszkiewicz, A. J., Rasmussen, T. E., & Brody, D. L. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.599268 · Cited by 10

Feasibility and Utility of a Flexible Outcome Assessment Battery for Longitudinal Traumatic Brain Injury Research: A TRACK-TBI Study

Bodien, Y. G., Barber, J. K., Taylor, S. R., Boase, K., Corrigan, J. D., DIKMEN, S. S., Gardner, R. C., Kramer, J. H., Levin, H. S., Machamer, J., et al. (2022) · Journal of Neurotrauma · doi:10.1089/neu.2022.0141 · Cited by 10

Efficacy of Progesterone for Acute Traumatic Brain Injury: a Meta-analysis of Randomized Controlled Trials

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Reprograming Clots for In Vivo Chemical Targeting in Traumatic Brain Injury

Kandell, R. M., Wu, J. R., & Kwon, E. J. (2024) · Advanced Materials · doi:10.1002/adma.202301738 · Cited by 9

Spatial Measurement and Inhibition of Calpain Activity in Traumatic Brain Injury with an Activity-Based Nanotheranostic Platform

Madias, M. I., Stessman, L. N., Warlof, S. J., Kudryashev, J. A., & Kwon, E. J. (2024) · ACS Nano · doi:10.1021/acsnano.4c06052 · Cited by 9

Progesterone Is More Effective Than Dexamethasone in Prolonging Overall Survival and Preserving Neurologic Function in Experimental Animals with Orthotopic Glioblastoma Allografts

Cheng, S. Y., Yeung, W. L. R., Zhang, P. D., Li, N., Kiang, M. Y. K., & Leung, G. (2019) · World Neurosurgery · doi:10.1016/j.wneu.2019.01.113 · Cited by 9

Multifunctional Nanoparticles and Nanoclusters as a Theranostics and Symptoms Disappearing Agent for Traumatic Brain Injury

Zoey, F. L., Ghosh, K. K., Palanivel, M., Gulyás, B. Z., & Padmanabhan, P. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202300010 · Cited by 9

Traumatic brain injury heterogeneity affects cell death and autophagy

McDonald, B. Z., Tarudji, A. W., Zhang, H., Ryu, S., Eskridge, K. M., & Kievit, F. M. (2024) · Experimental Brain Research · doi:10.1007/s00221-024-06856-1 · Cited by 9

Catastrophic consequences: can the feline parasite Toxoplasma gondii prompt the purrfect neuroinflammatory storm following traumatic brain injury?

Baker, T. L., Sun, M., Semple, B. D., Tyebji, S., Tonkin, C. J., Mychasiuk, R., & Shultz, S. R. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01885-3 · Cited by 11

Moderators of gene-outcome associations following traumatic brain injury

Carmichael, J. J., Hicks, A. J., Spitz, G., Gould, K. R., & Ponsford, J. L. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.08.015 · Cited by 11

Hippocampal Expression of Cytochrome P450 1B1 in Penetrating Traumatic Brain Injury

Lidin, E., Sköld, M. K., Angéria, M., Davidsson, J., & Risling, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020722 · Cited by 9

Dexamethasone for the treatment of traumatic brain injured patients with brain contusions and pericontusional edema

Pérez‐Bárcena, J., Castaño-León, A. M., Lagares, A., Barea‐Mendoza, J. A., Navarro-Main, B., Pons, J. P., Párraga, L. D. M. P., Ibáñez, J., Chico‐Fernández, M., Llompart‐Pou, J. A., et al. (2021) · Medicine · doi:10.1097/md.0000000000024206 · Cited by 8

Establishing ground truth in the traumatic brain injury literature: if replication is the answer, then what are the questions?

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Conjugated Linoleic Acid Administration Induces Amnesia in Male Sprague Dawley Rats and Exacerbates Recovery from Functional Deficits Induced by a Controlled Cortical Impact Injury

Geddes, R. I., Hayashi, K., Bongers, Q., Wehber, M., Anderson, I. M., Jansen, A. D., Nier, C., Fares, E., Farquhar, G., Kapoor, A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169494 · Cited by 8

Exogenous progesterone is neuroprotective following injury to the male zebra finch brain

Blackshear, K. J., Giessner, S., Hayden, J. P., & Duncan, K. A. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.24060 · Cited by 8

An evidence-based methodology for systematic evaluation of clinical outcome assessment measures for traumatic brain injury

Christoforou, A., Armstrong, M. J., Bergin, M. J. G., Robbins, A., Merillat, S. A., Erwin, P. J., Getchius, T. S. D., McCrea, M., Markowitz, A. J., Manley, G. T., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0242811 · Cited by 9

Lissencephaly-1 mutations enhance traumatic brain injury outcomes in Drosophila

Katzenberger, R. J., Ganetzky, B., & Wassarman, D. A. (2023) · Genetics · doi:10.1093/genetics/iyad008 · Cited by 7

Effects of Sex Steroids on Damaged Neural Systems

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A Model of Traumatic Brain Injury Oligomerizes Tau in Cortical Organoids and Induces Clinically Relevant Pathologies that Synergize with MAPT Mutation

Shiravi, S., Yufa, A., Papavasileiou, P., Lotz, S., Murphy, D., Bertucci, T. B., Temple, S., & Finan, J. D. (2025) · Journal of Neurotrauma · doi:10.1177/08977151251374286 · Cited by 6

An updated Barnes maze protocol for assessing the outcome of controlled cortical impact mouse models of traumatic brain injury

Gee, C. C., Steffen, R., & Kievit, F. M. (2023) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2023.109866 · Cited by 6

NTS-105 decreased cell death and preserved long-term potentiation in an in vitro model of moderate traumatic brain injury

Dwyer, M. K. R., Amelinez-Robles, N., Polsfuss, I., Herbert, K. L., Kim, C., Varghese, N. J., Parry, T. J., Buller, B., Verdoorn, T. A., Billing, C. B., et al. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114608 · Cited by 6

Impact of Conjugation Chemistry on the Pharmacokinetics of Peptide–Polymer Conjugates in a Model of Traumatic Brain Injury

Wu, J. R., Canjels, A., Miyauchi, R., & Kwon, E. J. (2025) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.5c00175 · Cited by 6

Intralipid Vehicle Does Not Interfere with the Efficacy of Progesterone in Attenuating Edema following Traumatic Brain Injury

Wali, B., Stein, D. G., & Sayeed, I. (2017) · Journal of Neurotrauma · doi:10.1089/neu.2016.4845 · Cited by 5

Biological Sex/Gender and Biopsychosocial Determinants of Traumatic Brain Injury Recovery Trajectories

Niemeier, J. P. (2019) · Current Physical Medicine and Rehabilitation Reports · doi:10.1007/s40141-019-00238-3 · Cited by 5

Systemic treatment with human amnion epithelial cells after experimental traumatic brain injury

Kim, H. A., Semple, B. D., Dill, L. K., Pham, L., Dworkin, S., Zhang, S. R., Lim, R., Sobey, C. G., & McDonald, S. J. (2020) · Brain Behavior & Immunity - Health · doi:10.1016/j.bbih.2020.100072 · Cited by 5

Traumatic Brain Injury in a Well: A Modular Three-Dimensional Printed Tool for Inducing Traumatic Brain Injury In vitro

Schlotterose, L., Beldjilali‐Labro, M., Schneider, G., Vardi, O., Hattermann, K., Even, U., Shohami, E., Haustein, H. D., Leichtmann‐Bardoogo, Y., & Maoz, B. M. (2023) · Neurotrauma Reports · doi:10.1089/neur.2022.0072 · Cited by 5

Editorial: Developing Successful Neuroprotective Treatments for TBI: Translational Approaches, Novel Directions, Opportunities and Challenges

Mondello, S., Hasan, A., & Shear, D. A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01326 · Cited by 5

Omega-3 Fatty Acids and Traumatic Injury in the Adult and Immature Brain

Valero-Hernandez, E., Tremoleda, J. L., & Michael-Titus, A. T. (2024) · Nutrients · doi:10.3390/nu16234175 · Cited by 5

The immunological paradox of CD4⁺ T cells in traumatic brain injury

Zhao, Q., Chen, B., Ai, W.-Q., Brazhe, N. A., Liu, D., Zhu, L., & Wen, M. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000003689 · Cited by 4

Enhancing neurogenesis after traumatic brain injury: The role of adenosine kinase inhibition in promoting neuronal survival and differentiation

Campbell, A., Lai, T., Wahba, A. E., Boison, D., & Gebril, H. M. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114930 · Cited by 4

The efficacy of progesterone 1 mg kg-1 every 12 hours over 5 days in moderate-to-severe traumatic brain injury: A meta-analysis of randomized controlled trials

Zhang, J., Wang, H., Li, Y., Zhang, H., & Dong, L. (2020) · Clinical Neurology and Neurosurgery · doi:10.1016/j.clineuro.2020.106131 · Cited by 4

Co-Expression Network Analysis of MicroRNAs and Proteins in Severe Traumatic Brain Injury: A Systematic Review

Osgood, C. E., Ahmed, Z., & Pietro, V. D. (2021) · Cells · doi:10.3390/cells10092425 · Cited by 4

Overview of Traumatic Brain Injury (TBI)

Moore, D. F., Jaffee, M. S., Ling, G. S. F., & Radovitzky, R. (2019) · Springer eBooks · doi:10.1007/978-3-030-22436-3_1 · Cited by 4

The Use of Estrogen for the Treatment of Traumatic Brain Injury

Hubbard, W. J., & Chaudry, I. H. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802686-1.00010-9 · Cited by 4

Understanding the complexities of traumatic brain injury: A big data approach to a big disease

Agoston, D. V. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.04.018 · Cited by 4

Prehospital Intubation: Further Confounders in Trial Results

Sayeed, I., Atif, F., Espinosa‐García, C., Wali, B., Turan, N., Yousuf, S., & Stein, D. G. (2018) · Prehospital Emergency Care · doi:10.1080/10903127.2017.1402111 · Cited by 4

Testing the Efficacy of Minocycline Treatment in an Awake, Female Rat Model of Repetitive Mild Head Injury

Hightower, R., Brengel, E. K., Prom, S., Kulkarni, P., & Ferris, C. F. (2024) · Journal of Experimental Neurology · doi:10.33696/neurol.5.097 · Cited by 3

Rotamer-Controlled Self-Immolative Linkers Enable Tunable Release of Neurosteroid Oxime Prodrugs

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Bispecific self-assembled peptides as supra-growth factors for preventing endotheliopathy and improving survival of traumatic brain injury in mice

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