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Mechanism of crosslinking of proteins by glutaraldehyde III. Reaction with collagen in tissues
Abstract
Bovine pericardium, a dense collagenous connective tissue, was crosslinked with glutaraldehyde using different modalities of fixation. The degree of crosslinking was evaluated as a function of the ability of CNBr and pronase to solubilize collagen. Our results suggest that glutaraldehyde fixes primarily the surface of the fibers and creates a polymeric network which hinders the further crosslinking of the interstitium of the fiber. When a low concentration of glutaraldehyde was used, a slow time-dependent crosslinking process was observed. This slow process is maintained over a long period of time, greatly beyond that required for the actual penetration of glutaraldehyde to occur.
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Cited by
Glutaraldehyde as a crosslinking agent for collagen-based biomaterials
Olde Damink, L. H. H., Dijkstra, P. J., Van Luyn, M. J. A., Van Wachem, P. B., Nieuwenhuis, P., & Feijen, J. (1995) · Journal of Materials Science: Materials in Medicine · doi:10.1007/bf00123371 · Cited by 527
Photochemical crosslinking improves the physicochemical properties of collagen scaffolds
Chan, B. P., & So, K. ‐. (2005) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.30469 · Cited by 96
Metadata
- Authors
- Cheung, D. T., Perelman, N., Ko, E. C., & Nimni, M. E.
- Venue
- Connective Tissue Research
- Publisher
- Informa UK Limited
- Published
- 1985-01
- Volume
- 13
- Issue
- 2
- Pages
- 109-115
- ISSN
- 0300-8207 (ISSN-L)
- 1607-8438
- OpenAlex
- W2039638056
- Cited by
- 193
- References
- 0
- FWCI
- 3.74
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Mechanism of crosslinking of proteins by glutaraldehyde III. Reaction with collagen in tissues. https://app.cochat.ai/papers/10.3109/03008208509152389
- The paper
- Cheung, D. T., Perelman, N., Ko, E. C., & Nimni, M. E. (1985). Mechanism of crosslinking of proteins by glutaraldehyde III. Reaction with collagen in tissues. Connective Tissue Research. https://doi.org/10.3109/03008208509152389
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
