The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Influence of Substrate Nature and Immobilization of Implanted Dentin Matrix Components During Induction of Reparative Dentinogenesis
Abstract
The biological effects of isolated soluble dentin extracellular matrix components on the induction of reparative dentinogenesis in exposed cavities in ferret canine teeth have been shown to be blocked by immobilizing the extracellular matrix components on nitrocellulose or Millipore membranes during implantation. This contrasts with the picture of induction of odontoblast-like cell differentiation and reparative dentin deposition on existing insoluble dentin matrix of the exposure walls when the extracellular matrix components are implanted in lyophilized form. These data indicate the importance of an existing insoluble dentin matrix in providing a substrate to potentiate the growth factor-like activity of soluble isolated dentin extracellular matrix components in the induction of reparative dentinogenesis.
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“More severe injury causes odontoblast cell death. This results in an inflammatory response that, if properly managed, can lead to DPSC activation and differentiation into odontoblast‐like cells, producing reparative dentin [6].”
From Consensus‐Based Recommendations on Pulp Therapies in Primary and Permanent Teeth: IAPD Porto Forum (2026) · cites this paper as [6]
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Metadata
- Authors
- Smith, A. J., Tobias, R. S., Cassidy, N., Bégue-Kirn, C., Ruch, J. V., & Lesot, H.
- Affiliations
- University of Birmingham (GB)
- Venue
- Connective Tissue Research
- Publisher
- Informa UK Limited
- Published
- 1995-01
- Volume
- 32
- Issue
- 1-4
- Pages
- 291-296
- ISSN
- 0300-8207 (ISSN-L)
- 1607-8438
- OpenAlex
- W2148675359
- Cited by
- 43
- References
- 19
- Citations by year
- 2026: 1 · 2025: 1 · 2022: 4 · 2021: 3 · 2019: 2 · 2018: 3 · 2017: 3 · 2016: 2 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 0.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Connective Tissue Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Bone and Dental Protein Studies
- Health Sciences › Dentistry › Oral Surgery › Endodontics and Root Canal Treatments
- Health Sciences › Dentistry › Periodontics › Periodontal Regeneration and Treatments
- Keywords
- reparative dentinogenesis, dentin matrix proteins, substrate effects, odontoblast differentiation, exposed root surfaces, dentin regeneration
- MeSH terms
- Animals, Cell Differentiation, Collodion, Cuspid, Dental Cavity Preparation, Dental Pulp, Dentin, Dentin, Secondary, Dentinogenesis, Extracellular Matrix, Ferrets, Foreign-Body Reaction, Growth Substances, Membranes, Artificial, Micropore Filters, Odontoblasts, Solubility, Giant Cells
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