The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Mechanism of Action of Anti-Inflammatory Drugs
Abstract
Cyclooxygenase (COX) is the pivotal enzyme in prostaglandin biosynthesis. It exists in two isoforms, constitutive COX-1 (responsible for physiological functions) and inducible COX-2 (involved in inflammation). Inhibition of COX explains both the therapeutic effects (inhibition of COX-2) and side effects (inhibition of COX-1) of non-steroidal anti-inflammatory drugs (NSAIDs). A NSAID which selectively inhibits COX-2 is likely to retain maximal anti-inflammatory efficacy combined with less toxicity. The activity of a number of NSAIDs has been investigated in several test systems, showing that most of those marketed have higher activities against COX-1 or are equipotent against both isoforms. Adverse event data of marketed NSAIDs show a relationship between a poor safety profile and more potent inhibition of COX-1 relative to COX-2. There are several new non-steroidal COX-2 inhibitors in development. The most clinically advanced is meloxicam, which consistently demonstrates higher activity against COX-2 than COX-1 in several test systems.
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Cites
Mitchell, J. A., Akarasereenont, P., Thiemermann, C., Flower, R. J., & Vane, J. R. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.24.11693 · Cited by 1,659
Self-citationFLOWER, R. J., & VANE, J. R. (1972) · Nature · doi:10.1038/240410a0 · Cited by 779
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Cited by
Banks, W. A., Gray, A. M., Erickson, M. A., Salameh, T. S., Damodarasamy, M., Sheibani, N., Meabon, J. S., Wing, E. E., Morofuji, Y., Cook, D. G., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0434-1 · Cited by 636
Diclofenac: an update on its mechanism of action and safety profile
Gan, T. J. (2010) · Current Medical Research and Opinion · doi:10.1185/03007995.2010.486301 · Cited by 600
Phillips, R. K. S., Wallace, M. H., Lynch, P. M., Hawk, E., Gordon, G. B., Saunders, B. P., Wakabayashi, N., Shen, Y., Zimmerman, S., Godio, L., et al. (2002) · Gut · doi:10.1136/gut.50.6.857 · Cited by 441
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 357
Present status and strategy of NSAIDs-induced small bowel injury
Higuchi, K., Umegaki, E., Watanabe, T., Yoda, Y., Morita, E., Murano, M., Tokioka, S., & Arakawa, T. (2009) · Journal of Gastroenterology · doi:10.1007/s00535-009-0102-2 · Cited by 292
Metadata
- Authors
- Vane, J. R., & Botting, R. M.
- Venue
- Scandinavian Journal of Rheumatology
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 25
- Issue
- sup102
- Pages
- 9-21
- ISSN
- 0300-9742 (ISSN-L)
- 1502-7732
- OpenAlex
- W2017917394
- Cited by
- 465
- References
- 2
- FWCI
- 12.29
- Type
- journal article
- Language
- en
- Open access
- closed
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- Vane, J. R., & Botting, R. M. (1996). Mechanism of Action of Anti-Inflammatory Drugs. Scandinavian Journal of Rheumatology. https://doi.org/10.3109/03009749609097226
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