The DOI matches its Crossref record.
Preparation and Evaluation Of Drug-Containing Chitosan Beads
Abstract
Sulfadiazine beads were prepared by dropping drug-containing solutions of the positively charged polysaccharide, chitosan, into tripolyphosphate (TPP) solutions. The droplets instantaneously formed gelled spheres by ionotropic gelation, entrapping the drug within a three-dimensional network of the ionically linked polymer. To achieve maximum drug content, high payloads, short gelation times, low TPP concentrations, and a low internal to external phase ratio were required. The chitosan beads showed pH-dependent swelling and dissolution behavior. The beads swelled and dissolved in 0.1N HCl, while they stayed intact in simulated intestinal fluid. The release of sulfadiazine in 0.1N HCl decreased with increasing concentration of TPP, but was independent of the TPP concentration in intestinal fluids. The morphology of the beads was investigated by scanning electron microscopy. The porosity of the beads depended on the method of drying.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Calvo, P., Remuñan-López, C., Vila-Jato, J. L., & Alonso, M. J. (1997) · Pharmaceutical Research · doi:10.1023/a:1012128907225 · Cited by 817
Chitosan nanoparticles: Preparation, size evolution and stability
Rampino, A., Borgogna, M., Blasi, P., Bellich, B., & Cesàro, A. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.07.034 · Cited by 622
Marine Derived Polysaccharides for Biomedical Applications: Chemical Modification Approaches
D’Ayala, G. G., Malinconico, M., & Laurienzo, P. (2008) · Molecules · doi:10.3390/molecules13092069 · Cited by 499
Preparation and characterization of chitosan microparticles intended for controlled drug delivery
Ko, J. A., Park, H. J., Hwang, S. J., Park, J. B., & Lee, J. S. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(02)00487-8 · Cited by 462
Shu, X. Z., & Zhu, K. J. (2002) · International Journal of Pharmaceutics · doi:10.1016/s0378-5173(01)00943-7 · Cited by 334
Metadata
- Authors
- Bodmeier, R., Oh, K.-H., & Pramar, Y.
- Venue
- Drug Development and Industrial Pharmacy
- Publisher
- Informa UK Limited
- Published
- 1989-01
- Volume
- 15
- Issue
- 9
- Pages
- 1475-1494
- ISSN
- 0363-9045 (ISSN-L)
- 1520-5762
- OpenAlex
- W2100513140
- Cited by
- 202
- References
- 0
- FWCI
- 1.58
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Preparation and Evaluation Of Drug-Containing Chitosan Beads. https://app.cochat.ai/papers/10.3109/03639048909062758
- The paper
- Bodmeier, R., Oh, K.-H., & Pramar, Y. (1989). Preparation and Evaluation Of Drug-Containing Chitosan Beads. Drug Development and Industrial Pharmacy. https://doi.org/10.3109/03639048909062758
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
