Resynchronization of the Circadian Corticosterone Rhythm After a Light/Dark Shift in Juvenile and Adult Mice
Abstract
Most of the extensive literature concerning the resynchronization of circadian rhythms after a Zeitgeber shift is devoted to the dependence of resynchronization on the mode of the shift and the strength of the Zeitgeber, as well as on the circadian function investigated. Ontogenetic influences have rarely been investigated. Therefore, we studied the resynchronization of several circadian rhythms in juvenile and adult female laboratory mice. We present here the results concerning the corticosterone rhythm. The daily rhythms were determined as transverse profiles (2-h intervals) before as well as 3, 7, and 14 days after an 8-h phase delay of the light/dark cycle produced by a single prolongation of dark time. The corticosterone concentration in serum was determined radioimmunologically. In the control animals the daily patterns were bimodal, with main maxima at the end of the light time and secondary ones just after lights on. Ontogenetic differences were small. In adult mice the amplitude was slightly increased due to an increase in the maximum values, and the time of highest hormone concentrations was slightly phase advanced. In juvenile mice, a distinct daily pattern with a phase position in relation to the light/dark cycle corresponding to that of control animals was present on the 3rd day after the Zeitgeber shift. The daily mean as well as the minimum and maximum values increased initially and reached the values of control animals during the second week. In adult animals, a pronounced daily rhythm with the normal phase position was present only at the 7th postshift day. The amplitude, daily mean, and maximum values were decreased, and the minimum values were increased. The initial values were not reached even after 2 weeks. The results show that resynchronization was faster in juvenile mice compared with adult mice. As a possible cause for the observed age-related differences, a not yet stabilized phase-coupling between various circadian rhythms is supposed.
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There is evidence in the literature that there might be a pubertal shift in the timing of daily rhythms in other species, including rhesus macaques, laboratory mice, and fat sand rats.
“We also found evidence in the literature that there might be a pubertal shift in the timing of daily rhythms in other species, including rhesus macaques (Figure 2B), laboratory mice, and fat sand rats [60, 137, 197, 199, further reviewed in 70].”
From The neuroendocrine control of the circadian system: Adolescent chronotype (2012) · cites this paper as [197]
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References 18 · Cited by 39
- Authors
- Weinert, D., Eimert, H., Erkert, H. G., & Schneyer, U.
- Affiliations
- University of Cologne (DE)
- University Hospital in Halle (DE)
- University of Tübingen (DE)
- Venue
- Chronobiology International
- Publisher
- Informa UK Limited
- Published
- 1994-01
- Volume
- 11
- Issue
- 4
- Pages
- 222-231
- ISSN
- 0742-0528 (ISSN-L)
- 1525-6073
- OpenAlex
- W2170015908
- Cited by
- 39
- References
- 18
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 2
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Chronobiology International (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- phase lag, ontogeny, juvenile mice, adult mice, age differences, phase coupling, serum corticosterone
- MeSH terms
- Age Factors, Animals, Circadian Rhythm, Corticosterone, Darkness, Female, Light, Mice, Inbred ICR, Time Factors, Mice
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