Disulfiram in severe alcoholism–an open controlled study
Abstract
BACKGROUND: Disulfiram is used to a great extent in Denmark to treat alcoholism but the evidence is limited. AIM: To study the effect of supervised disulfiram treatment in alcohol dependence. Subjects were recruited from a psychiatric emergency ward following alcohol withdrawal treatment. METHODS: A total of n=39 patients were openly randomized to either disulfiram 800 mg twice a week for 26 weeks (n=19) or no disulfiram (n=20). All patients were also treated with cognitive behavioural therapy (CBT) in groups. RESULTS: The rate of abstinence was 20% and 26% in the control and disulfiram group, respectively. This difference was not statistically significant (NS). A trend towards increased mean time to first drink was found in the disulfiram group (96 vs. 76 days in the control group, NS), while fewer patients in this group completed CBT group therapy (41% vs. 67% in the control group, NS). Alcohol-free days were 100 days in both groups (NS). CONCLUSION: Supervised disulfiram administration did not have any major impact on the treatment outcome.
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In combined control groups, six participants reported serious adverse events requiring hospitalization from three studies.
“In the combined control groups, six participants reported serious adverse events requiring hospitalization from three studies [38], [39], [42].”
From Disulfiram Efficacy in the Treatment of Alcohol Dependence: A Meta-Analysis (2014) · cites this paper as [42]
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References 13 · Cited by 26
- Authors
- Ulrichsen, J., Nielsen, M. K., & Ulrichsen, M.
- Affiliations
- Copenhagen University Hospital (DK)
- Corresponding author
- Ulrichsen, Jakob
- Venue
- Nordic Journal of Psychiatry
- Publisher
- Informa UK Limited
- Published
- 2010-03-18
- Volume
- 64
- Issue
- 6
- Pages
- 356-362
- ISSN
- 0029-1455 (ISSN-L)
- 0803-9488
- 1502-4725
- OpenAlex
- W2079342742
- Cited by
- 26
- References
- 13
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 1 · 2016: 3 · 2014: 4 · 2013: 1 · 2012: 2
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nordic Journal of Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Aase og Ejnar Danielsens Fond
- Fonden til Lægevidenskabens Fremme
- Topics
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Neurology › Alcoholism and Thiamine Deficiency
- Health Sciences › Medicine › Pathology and Forensic Medicine › Alcohol Consumption and Health Effects
- Keywords
- disulfiram, alcoholism, alcohol withdrawal, cognitive behavioral therapy, group therapy, abstinence, treatment outcomes
- MeSH terms
- Alcohol Deterrents, Alcoholism, Ambulatory Care, Combined Modality Therapy, Denmark, Disulfiram, Dose-Response Relationship, Drug, Drug Administration Schedule, Emergency Services, Psychiatric, Female, Follow-Up Studies, Humans, Male, Patient Admission, Patient Dropouts, Psychotherapy, Group, Temperance, Cognitive Behavioral Therapy, Secondary Prevention
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