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Cited by 22Biosimilars and Bioanalytical MethodsRheumatoid Arthritis Research and TherapiesPsoriasis: Treatment and Pathogenesis

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

Chronic inflammatory diseases: Do immunological patterns drive the choice of biotechnology drugs? A critical review

Sozzani, Silvano, Abbracchio, Maria P., Annese, Vito, Danese, Silvio, De Pità, Ornella, De Sarro, Giovambattista, Maione, Sabatino, Olivieri, Ignazio, Parodi, Aurora, Sarzi-Puttini, Piercarlo·2014·Autoimmunity
DOI 10.3109/08916934.2014.897333
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Abstract

Chronic inflammatory diseases represent a heterogeneous group of conditions that can affect practically any organ or system. An increasing number of biologic agents have been developed to selectively target the cell populations and signaling pathways involved in chronic inflammation, including cytokines, monoclonal antibodies and engineered receptors. This approach has been remarkably successful in alleviating some of the signs and symptoms of refractory autoimmune diseases. The use of this therapeutic strategy is likely to increase with the introduction of biosimilar agents. The different nature of these biological products makes the comparison of their pharmaceutical and clinical characteristics difficult, including safety and potency and these issues may be particularly relevant in the case of biosimilars. In addition, the heterogeneity of autoimmune diseases and of autoimmune patients, further adds to the complexity of choosing the right drug for each patient and predicting efficacy and safety of the treatment. In this review, we summarize actual knowledge about current biological agents and their use in autoimmune diseases, with a special emphasis for rheumatoid arthritis, inflammatory bowel diseases and psoriasis. The purpose of this analysis is to address the most critical issues raised by the rapid advancements in this field over recent years, and to acknowledge the potentially valuable gains brought about by the increasing availability of these new biologic agents.

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  • Some conditions involving excess TNF are currently co-treated with monoclonal antibodies that neutralize TNF.

    “Some of these conditions are currently co-treated with monoclonal antibodies that neutralize this cytokine (16).”

    From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [16]

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Metadata

Authors
Sozzani, S., Abbracchio, M. P., Annese, V., Danese, S., De Pità, O., De Sarro, G., Maione, S., Olivieri, I., Parodi, A., & Sarzi-Puttini, P.
Affiliations
  • IRCCS Humanitas Research Hospital (IT)
  • University of Milan (IT)
  • Azienda Ospedaliero-Universitaria Careggi (IT)
  • Fondazione Humanitas per la Ricerca (IT)
  • University of Campania "Luigi Vanvitelli" (IT)
  • Ospedale San Carlo (IT)
  • Ospedale Policlinico San Martino (IT)
Corresponding author
Sozzani, Silvano
ORCID
Venue
Autoimmunity
Publisher
Informa UK Limited
Published
2014-04-03
Volume
47
Issue
5
Pages
287-306
ISSN
  • 0891-6934 (ISSN-L)
  • 1607-842X
DOI
10.3109/08916934.2014.897333
OpenAlex
W1993073854
Cited by
22
References
1
Citations by year
2025: 1 · 2024: 4 · 2023: 1 · 2022: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 1 · 2015: 4 · 2014: 1
FWCI
0.29
Type
journal article
Language
en
Open access
closed
Locations
  • Autoimmunity (publishedVersion)
  • PubMed (publishedVersion)
  • Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion)
  • CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
  • IRIS Research product catalog (Sapienza University of Rome) (submittedVersion)
  • Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Biosimilars and Bioanalytical Methods
  • Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
chronic inflammatory diseases, biologic agents, biosimilars, autoimmune disease, rheumatoid arthritis, inflammatory bowel disease, psoriasis, cytokine inhibitors, monoclonal antibodies, engineered receptors, treatment selection
MeSH terms
Arthritis, Rheumatoid, Biological Products, Chronic Disease, Humans, Psoriasis, Recombinant Proteins, Tumor Necrosis Factor-alpha, Inflammatory Bowel Diseases, Autoimmunity, Molecular Targeted Therapy, Biosimilar Pharmaceuticals

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