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Anti-Myosin Humoral Immune Response Following Cardiac Injury
Abstract
A sensitive and highly specific ELISA assay was developed to determine the anti-myosin humoral immune response (AMA) in various heart diseases: acute viral myocarditis, infective endocarditis, acute myocardial infarction, and valve and coronary bypass surgery. The mean study entry AMA titer of each patient group was already significantly increased compared with age matched controls. During further follow-up (90 d) all the groups except for endocarditis showed a significant increase of AMA titer compared with their entry titer. Anti-myosin antibody titer were higher after cardiac surgery than after myocardial infarction or inflammatory heart disease. These results suggest that anti-myosin immune response is not limited to infectious processes in which the pathogen induces antibodies which cross-react with heart constituents but is merely caused by direct cardiac injury. Myosin as a major compound of heart cellular proteins turned out to be a good candidate to trigger immune response after cardiac injury.
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Autoantibodies targeting heart antigens are present in patients with viral myocarditis.
“numerous clinical studies have reported the presence of autoantibodies targeting heart antigens in patients with viral myocarditis”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [16]
Elevated levels of antimyosin autoantibodies are present in the serum of myocarditis patients and murine models, as well as in other cardiovascular disease conditions.
“an elevated level of antimyosin autoantibodies in the serum of both myocarditis patients and murine models, as well as in other cardiovascular disease conditions”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [16]
In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions.
“In earlier studies, autoantibodies targeting heart antigens have been identified in both myocarditis patients and animal models, regardless of the underlying cause-viral infections or existing autoimmune conditions. 15-18,57,189,190,218”
From Autoimmune Myocarditis, Old Dogs and New Tricks. (2024) · cites this paper as [16]
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Cited by
Sorted by citations
Complexities in the Relationship Between Infection and Autoimmunity
Root-Bernstein, R., & Fairweather, D. (2014) · Current Allergy and Asthma Reports · doi:10.1007/s11882-013-0407-3 · Cited by 98
Autoimmune Myocarditis, Old Dogs and New Tricks.
Won, T., Song, E. J., Kalinoski, H. M., Moslehi, J. J., & Čiháková, D. (2024) · Circulation Research · doi:10.1161/circresaha.124.323816 · Cited by 51
Metadata
- Authors
- De Scheerder, I. K., De Buyzere, M. L., Delanghe, J. R., Clementand, D. L., & Wieme, R. J.
- Affiliations
- Departments of Cardiology, University Hospital, Ghen, Belgium
- Ghent University Hospital (BE)
- ORCID
- Delanghe, J. R.
- Venue
- Autoimmunity
- Publisher
- Informa UK Limited
- Published
- 1989-01
- Volume
- 4
- Issue
- 1-2
- Pages
- 51-58
- ISSN
- 0891-6934 (ISSN-L)
- 1607-842X
- OpenAlex
- W1965727693
- Cited by
- 45
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2022: 1 · 2018: 1 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 3
- FWCI
- 0.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Autoimmunity (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
- Keywords
- anti-myosin antibodies, humoral immune response, cardiac injury, myocarditis, infective endocarditis, myocardial infarction, cardiac surgery, coronary artery bypass grafting, heart valve surgery, myosin, autoantibodies, ELISA assay
- MeSH terms
- Adolescent, Adult, Aged, Coronary Artery Bypass, Autoantibodies, Autoantigens, Child, Cross Reactions, Endocarditis, Bacterial, Female, Heart Injuries, Heart Valve Diseases, Humans, Male, Middle Aged, Myocardial Infarction, Myocarditis, Myosins
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