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A Comparison of Methods of Determining and Predicting the Pathogenicity of Mineral Fibers
Abstract
Most authors consider that long-term inhalation studies represent the most reliable method of obtaining data on the pathogenicity of mineral fibers. However, because of the length of time required and the great cost of inhalation work, other methods of examining the biological effects of mineral fibers have been used. The program of work described here was designed to compare a wide range of techniques, including inhalation, for determining the biological effects of a selection of man-made mineral fibers. Silicon carbide whiskers were examined as a very durable material and also a less durable glass microfiber (code 100/475) as a relatively soluble man-made vitreous fiber. Amosite asbestos was used as a positive control. long-term inhalation studies with full-life-span follow-up demonstrated that amosite and silicon carbide were both fibrogenic and carcinogenic in rats, while glass microfiber produced very little fibrosis and a few benign pulmonary tumors in numbers similar to those found in controls. Silicon carbide was unusual in that most of the tumors produced were pleural mesotheliomas. Early effects of the fibers were examined after a short period of inhalation, and the pathogenic dusts amosite and silicon carbide were found to produce rapid pulmonary inflammation as determined by the presence of significant numbers of neutrophils in pulmonary lavage fluid. Less pulmonary inflammation followed the inhalation of glass microfiber. Similarly, amosite and silicon carbide in…
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In the citing paper
“With chrysotile fibers, two studies reported higher biopersistence of long fibers than that of short fibers.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [105]
In the citing paper
“Davis et al. [105] determined the amount of chrysotile fibers. The persistence of long fibers, expressed by weight, was higher than that of short fibers.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [105]
In the citing paper
“According to Davis et al. [105] and Cullen et al. [106] the clearance rate of both fibers < 5 μm and > 20 μm was quite similar (≈60%), while that of fibers > 5 μm was lower (≈44%).”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [105]
In the citing paper
“With amphiboles, two studies reported lower clearance of long fibers in comparison with short fibers.”
From Quantification of short and long asbestos fibers to assess asbestos exposure: A review of fiber size toxicity (2014) · cites this paper as [105]
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Cited by
Sorted by citations
Donaldson, K., Aitken, R., Tran, L., Stone, V., Duffin, R., Forrest, G., & Alexander, A. (2006) · Toxicological Sciences · doi:10.1093/toxsci/kfj130 · Cited by 1,167
Self-citationBoulanger, G., Andujar, P., Pairon, J.-C., Billon-Galland, M.-A., Dion, C., Dumortier, P., Brochard, P., Sobaszek, A., Bartsch, P., Paris, C., et al. (2014) · Environmental Health · doi:10.1186/1476-069x-13-59 · Cited by 176
Bernstein, D., Castranova, V., Donaldson, K., Fubini, B., Hadley, J., Hesterberg, T., Kane, A., Lai, D., McConnell, E. E., Muhle, H., et al. (2005) · Inhalation Toxicology · doi:10.1080/08958370591001121 · Cited by 103
Self-citationSynthetic vitreous fibers: A review toxicology, epidemiology and regulations
Bernstein, D. M. (2007) · Critical Reviews in Toxicology · doi:10.1080/10408440701524592 · Cited by 65
Metadata
- Authors
- Davis, J. M. G., Brown, D. M., Cullen, R. T., Donaldson, K., Jones, A. D., Miller, B. C., Mcintosh, C., & Searl, A.
- Venue
- Inhalation Toxicology
- Publisher
- Informa UK Limited
- Published
- 1996-01
- Volume
- 8
- Issue
- 8
- Pages
- 747-770
- ISSN
- 0895-8378
- 1091-7691
- Cited by
- 36
- References
- 0
- Language
- en
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- Davis, J. M. G., Brown, D. M., Cullen, R. T., Donaldson, K., Jones, A. D., Miller, B. C., Mcintosh, C., & Searl, A. (1996). A Comparison of Methods of Determining and Predicting the Pathogenicity of Mineral Fibers. Inhalation Toxicology. https://doi.org/10.3109/08958379608995209
